ABSTRACT
This paper examines factors that are essential for a successful implementation of healthcare informatics in professional curricula. These factors are related to the design framework of the learning materials that have been developed as a part of a Dutch model curriculum of healthcare informatics. Next some ideas and suggestions for a successful implementation are presented.
Subject(s)
Curriculum , Health Personnel/education , Medical Informatics/education , HumansABSTRACT
Pheromone produced by the hairpencil glands of interspecific hybrid- and backcross-generation males from crosses betweenHeliothis virescens (F.) withH. subflexa (Gn.) was studied. Males of reciprocal F1 hybrids, all of which had hairpencil glands morphologically similar to those ofH. virescens, produced neither the same pheromone blend nor amounts of pheromone that were produced by males ofH. virescens. Instead, these hybrid males produced pheromone that was quantitatively and qualitatively similar to that produced byH. subflexa. Hairpencil gland extracts from males obtained from backcrossing F1 females of either cross to males ofH. subflexa were the same as those ofH. subflexa. However, extracts from backcross males of crosses between F1 females andH. virescens were variable. Some extracts from these backcross males were like those ofH. virescens while others were either likeH. subflexa or were intermediate between those of the parent species. These results showed that the production of pheromone by the hairpencil glands of hybrid and backcross males is under the dominant regulation of autosomal genes of theH. subflexa genome.
ABSTRACT
The sequential culture of rat hepatocytes and post-implantation rat embryos has been proposed as a model for the in vitro testing of pro-teratogens. Comparing this model with a model in which embryos and hepatocytes are cultured simultaneously a striking difference in sensitivity was noted. To address the question of whether this difference could be explained by different sex and/or Aroclor 1254 pretreatment of the rats providing the hepatocytes, an experiment was designed with four groups: male Aroclor 1254 pretreated (M(1)), male untreated, pregnant female Aroclor 1254 pretreated (F(1)) and pregnant female untreated rats. Hepatocytes were incubated in the presence of cyclophosphamide (CP) and rat embryos were cultured in the media derived from the hepatocyte culture (i.e. the sequential culture model). Additionally, the CP concentrations of the media were analysed and subsequently the media were tested in a bacterial mutagenicity test (Salmonella typhimurium TA1535). With a CP concentration of 300 mum, M(1) produced maximum embryotoxicity and mutagenicity after 4 hr of hepatocytes incubation. All other groups showed no or only a slight increase in embryotoxicity and mutagenicity for all hepatocyte incubations. M(1) was also quickest to eliminate CP from the medium. These results indicate that despite a strong increase in total cytochrome P-450 in both sexes as a result of Aroclor 1254 pretreatment, and in the absence of a significant difference in total cytochrome P-450 between M(1) and F(1), Aroclor 1254 pretreatment has a much more pronounced effect in male rats than in pregnant female rats with regard to the production of embryotoxic and mutagenic metabolites of CP.
ABSTRACT
We describe two sibs with prenatal-onset growth deficiency, microcephaly, cataracts, mental retardation, enamel hypoplasia, immune deficiency, and generalized delay of ossification. The combination appears to constitute a previously undescribed autosomal recessive syndrome.
