[Polymorphism of N-acetyltransferase-2 and pathogenesis of neoplastic diseases]. / Polimorfizm N-acetylotransferazy 2 a patogeneza chorób nowotworowych.

Pathogenesis of many diseases is connected with influence of environmental factors with individual genetic sensitivity dependent among others on detoxification enzymes. Mutations of N-acetyltransferase-2 lead to decreased enzyme function. In this review the focus is on discussion about the connection between the polymorphic N-acetyltransferase-2 and increase in the risk of cancer, atopic disease and adverse drug effects.

[The role of N-acetyltransferase polymorphism in the pathogenesis of Parkinson's disease]. / Rola polimorfizmu N-acetylotransferazy 2 w patogenezie choroby parkinsona.

Pathogenesis of many diseases is related to the influence of noxious environmental agents coupled with individual genetic sensitivity that depends on the function of detoxificating enzymes. One of the latter is N-acetyltransferase 2 whose mutations lead to an impairment of the enzyme function. Genetically determined acetylation rate reduction with exposure to neurotoxins may contribute to the development of Parkinson's disease (PD). While both genetic and environmental factors are implicated in etiology of PD, genetic factors may play a crucial role in early-onset Parkinson's disease (in patients aged under 50).