Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Brain Res ; 1250: 14-9, 2009 Jan 23.
Article in English | MEDLINE | ID: mdl-19038234

ABSTRACT

Autism spectrum disorders (ASD) is a group of behaviorally defined neurodevelopmental disabilities characterized by multiple genetic etiologies and a complex presentation. Several studies suggest the involvement of the serotonin system in the development of ASD, but only few have investigated serotonin receptors. We have performed a case-control and a family-based study with 9 polymorphisms mapped to two serotonin receptor genes (HTR1B and HTR2C) in 252 Brazilian male ASD patients of European ancestry. These analyses showed evidence of undertransmission of the HTR1B haplotypes containing alleles -161G and -261A at HTR1B gene to ASD (P=0.003), but no involvement of HTR2C to the predisposition to this disease. Considering the relatively low level of statistical significance and the power of our sample, further studies are required to confirm the association of these serotonin-related genes and ASD.


Subject(s)
Autistic Disorder/genetics , Genetic Predisposition to Disease , Polymorphism, Single Nucleotide , Receptor, Serotonin, 5-HT1B/genetics , Receptor, Serotonin, 5-HT2C/genetics , Alleles , Brazil , Case-Control Studies , Family , Genotype , Haplotypes , Humans , Male , Sequence Analysis, DNA
SELECTION OF CITATIONS
SEARCH DETAIL
...