ABSTRACT
INTRODUCTION: Prostate cancer has an increasing global burden. The clinical course varies from an indolent disease to a rapidly aggressive cancer. It is associated with higher mortality in less developed nations due to late presentation. The Gleason scoring system for prostatic adenocarcinoma has prognostic implications in diagnosed cases. Obesity has been associated with the evolution of many cancers including prostate cancer. There are conflicting reports on the relationship between obesity, as measured by body mass index (BMI), and prostate cancer aggressiveness, as measured by Gleason score. This study is aimed to determine if a correlation exists between BMI and Gleason score in men with prostate cancer. METHODOLOGY: This was a prospective, hospital-based, cross-sectional study involving consecutive patients with prostate cancer. Clinical evaluation including anthropometry, digital rectal examination, and relevant investigations were done for each patient and data collected with pro forma. This was followed by prostate needle biopsy and those diagnosed with adenocarcinoma of the prostate had their Gleason grades and scores obtained. Data were analyzed statistically using Spearman Correlation. RESULTS: The mean age of the patients was 69.54 ± 8.61 years (range 47-83 years). The BMI ranged from 16.98 to 36.45 kg/m2, with a mean of 27.03 ± 5.03 kg/m2. Twenty-six of the patients (36.1%) were overweight and 34.7% were obese. The mean total prostate-specific antigen was 118.65 ± 84.43 ng/ml, with a range of 31-406 ng/ml. The modal Gleason score was 9 with a range of 4-10. There was a strong positive correlation between BMI and Gleason score (r = 0.817, P = 0.0003). CONCLUSION: The BMI of patients with prostate cancer correlated positively with their Gleason score.
ABSTRACT
BACKGROUND: Testicular biopsy is an acknowledged method of examination of the testes for diagnostic and therapeutic purposes. We describe the pattern of testicular histologies in our environment. MATERIALS AND METHODS: We carried out a retrospective review of testicular histology results from the Pathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, over a 5-year period, January 2008 to December 2012. RESULTS: During the period, 285 testicular histologies were reported. Eighty-one (28.4%) specimens were pathological specimens, while 204 (71.6%) were nonpathological specimens. Thirty-seven (13.0%) of the histology reports were for diagnostic purpose while 248 (87.0%) were for therapeutic purpose. Based on the results, indications could also be categorized into three, benign testicular pathology, malignant testicular pathology, and testicular biopsy for male factor infertility. Thirty-seven cases (13.0%) were due to male factor infertility with complete spermatogenic arrest as the most common histological finding in 21 (56.8%) of the cases. Malignant testicular diseases accounted for 16 (5.6%) of the indications for testicular biopsies. Benign testicular diseases accounted for 28 (9.8%) of the indications for testicular biopsies. Hemorrhagic infarction from testicular torsion represented the commonest histology in 12 (42.9%) cases, followed by inflammations of the testes. CONCLUSION: Indications for testicular biopsy can be diagnostic and therapeutic. They can also be categorized into benign testicular diseases, malignant testicular diseases, and male infertility. Investigation for male factor infertility was the only diagnostic indication for testicular biopsy. The high incidence of locally and metastatic prostate cancer in males explains why therapeutic removal of the testis is common.
ABSTRACT
BACKGROUND: A carefully performed facial analysis can serve as a strong foundation for successful facial reconstructive and plastic surgeries, rhinoplasty or orthodontics. AIM: The purpose of this study is to determine the facial features and qualities of the Igbo Nigerian adult male using photometry. MATERIALS AND METHODS: One hundred and twenty subjects aged between 18 and 28 years were studied at the Anambra State University, Uli, Nigeria. The frontal and right lateral view photographs of their faces were taken and traced out on tracing papers. On these, two vertical distances, nasion to subnasal and subnasale to menton, and four angles, nasofrontal (NF), nasofacial, nasomental (NM) and mentocervical, were measured. RESULTS: The result showed that the Igbo Nigerian adult male had a middle face that was shorter than the lower one (41.76% vs.58.24%), a moderate glabella (NF=133.97°), a projected nose (NM=38.68°) and a less prominent chin (NM=125.87°). CONCLUSION: This study is very important in medical practice as it can be used to compare the pre- and post-operative results of plastic surgery and other related surgeries of the face.
ABSTRACT
Background: A carefully performed facial analysis can serve as a strong foundation for successful facial reconstructive and plastic surgeries; rhinoplasty or orthodontics. Aim: The purpose of this study is to determine the facial features and qualities of the Igbo Nigerian adult male using photometry. Materials and Methods: One hundred and twenty subjects aged between 18 and 28 years were studied at the Anambra State University; Uli; Nigeria. The frontal and right lateral view photographs of their faces were taken and traced out on tracing papers. On these; two vertical distances; nasion to subnasal and subnasale to menton; and four angles; nasofrontal (NF); nasofacial; nasomental (NM) and mentocervical; were measured. Results: The result showed that the Igbo Nigerian adult male had a middle face that was shorter than the lower one (41.76vs.58.24); a moderate glabella (NF=133.97o); a projected nose (NM=38.68o) and a less prominent chin (NM=125.87o). Conclusion: This study is very important in medical practice as it can be used to compare the pre- and post-operative results of plastic surgery and other related surgeries of the face
