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1.
J Am Med Dir Assoc ; 25(5): 789-795.e2, 2024 May.
Article in English | MEDLINE | ID: mdl-38640962

ABSTRACT

OBJECTIVE: Although aging has a strong impact on visual acuity (VA) and falls, their interaction is understudied in generally healthy older adults. This study aimed to examine if and to what extent baseline VA is associated with an increased risk of all and injurious falls over 3 years in generally healthy community-dwelling older adults. DESIGN: Observational analysis of DO-HEALTH, a double-blind, randomized controlled trial. SETTING AND PARTICIPANTS: Multicenter trial with 7 European centers: Zurich, Basel, Geneva (Switzerland), Berlin (Germany), Innsbruck (Austria), Toulouse (France), and Coimbra (Portugal), including 2157 community-dwelling adults aged 70 years and older without any major health events in the 5 years prior to enrollment, sufficient mobility, and good cognitive status. METHODS: The numbers of all and injurious falls were recorded prospectively by diary and in-person assessment every 3 months. Decreased VA at baseline was defined as better-eye VA lower than 1.0. We applied negative binomial regression models for all and injurious falls, adjusted for age, sex, prior falls, treatment allocation, study site, baseline body mass index, and use of walking aids. RESULTS: Among the 2131 participants included in this analysis (mean age: 74.9 years, 61.7% were women, 82.6% at least moderately physically active), 1464 (68.7%) had decreased VA. Overall, 3290 falls including 2116 injurious falls were recorded over 3 years. Decreased VA at baseline was associated with a 22% increased incidence rate of all falls [adjusted incidence rate ratio (aIRR) = 1.22, 95% CI 1.07, 1.38, P = .003] and 20% increased incidence rate of injurious falls (aIRR = 1.20, 95% CI 1.05, 1.37, P = .007). CONCLUSIONS AND IMPLICATIONS: Our findings suggest that decreased VA is an independent predictor of an about 20% increased risk of all and injurious falls, highlighting the importance of regular eye examinations and VA measurements for fall prevention, even in generally healthy and active older adults.


Subject(s)
Accidental Falls , Visual Acuity , Humans , Accidental Falls/statistics & numerical data , Aged , Male , Female , Visual Acuity/physiology , Prospective Studies , Aged, 80 and over , Double-Blind Method , Europe/epidemiology , Independent Living , Risk Assessment
2.
BMJ Qual Saf ; 32(8): 457-469, 2023 08.
Article in English | MEDLINE | ID: mdl-36948542

ABSTRACT

BACKGROUND: The second Multicenter Medication Reconciliation Quality Improvement Study demonstrated a marked reduction in medication discrepancies per patient. The aim of the current analysis was to determine the association of patient exposure to each system-level intervention and receipt of each patient-level intervention on these results. METHODS: This study was conducted at 17 North American Hospitals, the study period was 18 months per site, and sites typically adopted interventions after 2-5 months of preintervention data collection. We conducted an on-treatment analysis (ie, an evaluation of outcomes based on patient exposure) of system-level interventions, both at the category level and at the individual component level, based on monthly surveys of implementation site leads at each site (response rate 65%). We then conducted a similar analysis of patient-level interventions, as determined by study pharmacist review of documented activities in the medical record. We analysed the association of each intervention on the adjusted number of medication discrepancies per patient in admission and discharge orders, based on a random sample of up to 22 patients per month per site, using mixed-effects Poisson regression with hospital site as a random effect. We then used a generalised linear mixed-effects model (GLMM) decision tree to determine which patient-level interventions explained the most variance in discrepancy rates. RESULTS: Among 4947 patients, patient exposure to seven of the eight system-level component categories was associated with modest but significant reductions in discrepancy rates (adjusted rate ratios (ARR) 0.75-0.97), as were 15 of the 17 individual system-level intervention components, including hiring, reallocating and training personnel to take a best possible medication history (BPMH) and training personnel to perform discharge medication reconciliation and patient counselling. Receipt of five of seven patient-level interventions was independently associated with large reductions in discrepancy rates, including receipt of a BPMH in the emergency department (ED) by a trained clinician (ARR 0.40, 95% CI 0.37 to 0.43), admission medication reconciliation by a trained clinician (ARR 0.57, 95% CI 0.50 to 0.64) and discharge medication reconciliation by a trained clinician (ARR 0.64, 95% CI 0.57 to 0.73). In GLMM decision tree analyses, patients who received both a BPMH in the ED and discharge medication reconciliation by a trained clinician experienced the lowest discrepancy rates (0.08 per medication per patient). CONCLUSION AND RELEVANCE: Patient-level interventions most associated with reductions in discrepancies were receipt of a BPMH of admitted patients in the ED and admission and discharge medication reconciliation by a trained clinician. System-level interventions were associated with modest reduction in discrepancies for the average patient but are likely important to support patient-level interventions and may reach more patients. These findings can be used to help hospitals and health systems prioritise interventions to improve medication safety during care transitions.


Subject(s)
Hospitalization , Medication Reconciliation , Humans , Patient Discharge , Patient Transfer , Hospitals , Pharmacists
3.
Gerontology ; 69(1): 57-64, 2023.
Article in English | MEDLINE | ID: mdl-35443250

ABSTRACT

INTRODUCTION: Ageing trajectories range from delayed ageing with extended health to accelerated ageing, with an increased risk of frailty. We evaluated the prevalence and prospective change between health states among community-dwelling European older adults. METHODS: This prospective study is a secondary analysis of DO-HEALTH, a randomized trial that included adults aged 70 years and older across 5 European countries. Healthy agers (HA) fulfilled the Nurses' Health Study healthy ageing criteria and accelerated agers were non-HA being at least pre-frail according to the Fried frailty criteria. We assessed the proportion of participants changing between health states over 4 assessments and evaluated the odds of changing to a more favourable category. To increase reliability and avoid regression to the mean, we averaged the first 2 years and compared them to the average of the last 2 years. RESULTS: Of 2,157 participants, 12.4% were excluded for meeting both healthy ageing and pre-frailty criteria simultaneously. Among the remaining 1,889 participants (mean age 75.1 years, 60.9% female), 23.1% were initially HA, 44.4% were non-HA but not pre-frail, and 32.6% were pre-frail or frail. Subsequently, 65.3% remained in the same health state, 12.0% improved to a healthier state, and 22.8% progressed to a less advantageous state. After adjusting for sex, study centre, treatment, and body mass index, each year of age was associated with 6% lower odds of improving health states. Women had 35% higher odds than men of following a disadvantageous trajectory. CONCLUSION: We observed dynamic trajectories of ageing where transitioning to a healthier state became less likely with advancing age and among women.


Subject(s)
Frailty , Aged , Male , Humans , Female , Aged, 80 and over , Frailty/epidemiology , Prospective Studies , Frail Elderly , Reproducibility of Results , Aging , Independent Living , Geriatric Assessment
4.
Health Aff Sch ; 1(5): qxad062, 2023 Nov.
Article in English | MEDLINE | ID: mdl-38756981

ABSTRACT

Property insurance is an important tool for resiliency from the accelerating impacts of climate-intensified extreme weather events. However, disparities in property insurance payouts may reduce their potential protective effects. The objective of this study was to quantify disparities in insurance payouts by Texas' insurers after the 2021 Winter Storm Uri, and to understand if any socioeconomic factors were associated with higher rates of declined relief. We extracted data from the Texas Department of Insurance on rates of denied insurance claims by zip code and county at 1 month and 13 months into the recovery period. We then linked these data to community-level socioeconomic information. Finally, we produced separate linear regressions for each predictor and covariate. Across both time points, communities with a higher proportion of Hispanic people, primary Spanish speakers, people who did not graduate high school, and people living below the federal poverty line were significantly more likely to experience denied claims. Communities with higher social vulnerability scores also experienced more denied claims. While financial security is a critical social determinant of health, findings suggest that insurers may be engaging in structurally discriminatory practices and failing to provide relief for people from socially vulnerable communities in the wake of climate-intensified events.

5.
Med Care ; 60(6): 402-412, 2022 06 01.
Article in English | MEDLINE | ID: mdl-35315377

ABSTRACT

BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) implemented the Medicare durable medical equipment (DME) Competitive Bidding Program (CBP) in 2011. Since then, concerns have been raised regarding access to equipment and adverse health outcomes. OBJECTIVES: The aim was to evaluate whether the CBP was associated with changes in spending, utilization, and adverse health events (emergency department visits, hospitalizations, and falls). RESEARCH DESIGN: A comparative interrupted time series over 8 years was used to compare Round1 and Round2 bidding to nonbidding areas. Medicare fee for services claims were aggregated at the quarterly Metropolitan Statistical Area (MSA) level from 2009 to 2016. RESULTS: For the 3 evaluated DME (continuous positive airway pressure machines, oxygen supplies, and walkers), we found that implementation of the Medicare CBP was associated with reductions in per capita spending without changes in DME utilization or adverse health outcomes in CBP areas compared with nonbidding areas. For example, the slope change in the proportion of oxygen supplies purchasers in Round1 areas after implementation of Round1 was similar to the slope change in nonbidding areas (-0.0002; 95% CI: -0.0004, 0.0001; P=0.189). The difference in slope changes of emergency department visits and hospitalization in Round1 areas for oxygen supplies were (-0.0004; 95% CI: -0.0016, 0.0008; P=0.514) and (0.0002; 95% CI: -0.0010, 0.0014; P=0.757), respectively. Findings in Round2 areas after implementation of Round2 were similar to findings in Round1 areas. CONCLUSIONS: The Medicare DME CBP lowered Medicare expenditures while not reducing beneficiary access or increasing adverse outcomes.


Subject(s)
Competitive Bidding , Medicare , Aged , Centers for Medicare and Medicaid Services, U.S. , Durable Medical Equipment , Humans , Oxygen , United States
6.
Int J Gynecol Cancer ; 32(6): 781-787, 2022 06 06.
Article in English | MEDLINE | ID: mdl-35169070

ABSTRACT

OBJECTIVE: Chemotherapy has multiple adverse effects, including chemotherapy-related cognitive impairment, the phenomenon colloquially referred to as 'chemobrain'. The objective of this study was to understand patient-reported experiences of this phenomenon in relation to chemotherapy administration among gynecologic oncology patients. METHODS: A prospective patient-reported outcomes program was implemented in the Gynecologic Oncology clinic of a tertiary academic institution in January 2018. Patients with endometrial or ovarian cancer who received chemotherapy were included through September 2019 in this cohort study. Patients completed the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire. Serial responses were compared before, during, and after chemotherapy using a mixed effects linear regression with random effects for repeated measures within patients and a fixed effect for endometrial versus ovarian cancer. RESULTS: Fifty patients were included who completed a total of 152 patient-reported outcome measures. Thirty-five questionnaires were administered before chemotherapy, 59 during treatment, and 58 at a median of 161 days after the final cycle of chemotherapy. Seventy-one percent of patients reported no difficulties with concentration before chemotherapy, which remained stable after chemotherapy (72%). Sixty-six percent reported no difficulty with memory before chemotherapy versus 52% after chemotherapy. There were significant differences in feeling tension (p<0.001), worry (p<0.001), and depression (p=0.02) before and after chemotherapy on mixed effects linear regression, with higher levels of adverse emotional symptoms before chemotherapy administration compared with after. Women reported more interference with their social lives during chemotherapy (mean 1.08) compared with before (mean 0.85) and after chemotherapy (0.75, p=0.04). CONCLUSIONS: While no overt memory issues were discovered with serial administration of patient-reported outcome measures, rates of adverse emotional symptoms such as depression, tension, and worry diminished after chemotherapy administration. Further study is needed about the phenomenon of chemotherapy-related cognitive impairment using a larger cohort.


Subject(s)
Chemotherapy-Related Cognitive Impairment , Genital Neoplasms, Female , Ovarian Neoplasms , Carcinoma, Ovarian Epithelial , Cohort Studies , Female , Genital Neoplasms, Female/drug therapy , Humans , Ovarian Neoplasms/psychology , Patient Reported Outcome Measures , Prospective Studies , Quality of Life
7.
Health Serv Res ; 55(5): 722-728, 2020 10.
Article in English | MEDLINE | ID: mdl-32715464

ABSTRACT

OBJECTIVE: To determine if Medicare Shared Savings Program Accountable Care Organizations (ACOs) using cost reduction measures in specialist compensation demonstrated better performance. DATA SOURCES: National, cross-sectional survey data on ACOs (2013-2015) linked to public-use data on ACO performance (2014-2016). STUDY DESIGN: We compared characteristics of ACOs that did and did not report use of cost reduction measures in specialist compensation and determined the association between using this approach and ACO savings, outpatient spending, and specialist visit rates. PRINCIPAL FINDINGS: Of 160 ACOs surveyed, 26 percent reported using cost reduction measures to help determine specialist compensation. ACOs using cost reduction in specialist compensation were more often physician-led (68.3 vs 49.6 percent) and served higher-risk patients (mean Hierarchical Condition Category score 1.09 vs 1.05). These ACOs had similar savings per beneficiary year (adjusted difference $82.6 [95% CI -77.9, 243.1]), outpatient spending per beneficiary year (-24.0 [95% CI -248.9, 200.8]), and specialist visits per 1000 beneficiary years (369.7 [95% CI -9.3, 748.7]). CONCLUSION: Incentivizing specialists on cost reduction was not associated with ACO savings in the short term. Further work is needed to determine the most effective approach to engage specialists in ACO efforts.


Subject(s)
Accountable Care Organizations/statistics & numerical data , Health Expenditures/statistics & numerical data , Physician Incentive Plans/statistics & numerical data , Specialization/statistics & numerical data , Accountable Care Organizations/economics , Adult , Aged , Cost Control/economics , Cost Control/statistics & numerical data , Cross-Sectional Studies , Female , Humans , Male , Medicare/statistics & numerical data , Middle Aged , Physician Incentive Plans/economics , Specialization/economics , United States
8.
AIDS ; 34(4): 529-537, 2020 03 15.
Article in English | MEDLINE | ID: mdl-31764073

ABSTRACT

OBJECTIVES: To longitudinally measure LV diastolic function in HIV-exposed but uninfected (HEU) children perinatally exposed to ART. DESIGN: HEU children who were perinatally exposed to antiretroviral therapy (ART) may be at risk for adverse cardiac effects. We have previously reported that those children have decreased left ventricular (LV) mass, dimension, and septal thickness with increased contractility. METHODS: Serial echocardiograms were obtained at specific times from birth to 48 months from two groups of HIV-uninfected children: 148 HIV-negative children who were perinatally exposed to ART and 130 non-ART-exposed HIV-unexposed healthy controls. The following LV diastolic indices were obtained: mitral valve early and late diastolic velocity (E and A), tissue Doppler-derived LV-free wall and septal early diastolic velocity (LV e' and sep e'). RESULTS: All echocardiographic indices were significantly different in ART-exposed children compared with ART-unexposed healthy controls. Both E and A were overall lower at all ages by 8.28 cm/s (P = 0.0002) and 13.46 cm/s (P < 0.0001) respectively. E/A ratio was higher by 0.27, 0.46, and 0.28 units at birth, 1 year and 2 years of age, respectively (all P ≤ 0.01). Moreover, LV e' and sep e' were overall lower at all ages by 0.84 cm/s (P = 0.01) and 0.47 cm/s (P = 0.02), respectively. CONCLUSION: Children who were exposed to ART in utero have subclinical yet significant differences in specific LV diastolic indices. Follow-up with serial echocardiograms are recommended in this population to further assess the potential cardiac toxicity of perinatal exposure to ART.


Subject(s)
Anti-Retroviral Agents/therapeutic use , HIV Infections/drug therapy , Maternal-Fetal Exchange , Pregnancy Complications, Infectious/drug therapy , Ventricular Dysfunction, Left/physiopathology , Ventricular Function, Left/drug effects , Child, Preschool , Diastole , Echocardiography , Female , Humans , Infant , Infant, Newborn , Male , Pregnancy
9.
J Am Geriatr Soc ; 67(11): 2245-2253, 2019 11.
Article in English | MEDLINE | ID: mdl-31490547

ABSTRACT

BACKGROUND/OBJECTIVES: Bundled payments are an alternative payment model in which a hospital takes accountability for the costs of a 90-day episode of care. Such models are meant to improve care through better coordination across care settings, but could have adverse consequences for frail adults if they lead to inappropriate cuts in necessary post-acute care. DESIGN: Retrospective claims-based analysis of hospitals' first year of participation in Medicare's Bundled Payments for Care Improvement (BPCI) program. SETTING: US hospitals. PARTICIPANTS: A total of 641 146 Medicare beneficiaries admitted to 688 BPCI programs and 1276 matched control hospitals for myocardial infarction, heart failure, pneumonia, sepsis, chronic obstructive pulmonary disease, or major joint replacement of the lower extremity in 2012 to 2016. INTERVENTION: Participation in BPCI. MEASUREMENTS: Proportion of patients in each quartile of a validated claims-based frailty index, total and setting-specific standardized Medicare payments per episode, days at home, 90-day readmissions, and 90-day mortality. RESULTS: Higher levels of frailty were associated with higher Medicare payments and worse clinical outcomes (for the medical composite, costs per episode were $11 921, $17 348, $22 828, and $29 157 across frailty quartiles; days at home were 70.1, 60.4, 54.3, and 51.5; 90-day readmission rates were 16.0%, 27.0%, 38.2%, and 50.9%; and 90-day mortality rates were 15.4%, 22.5%, 25.1%, 21.3%); patterns were similar for joint replacement. Under the BPCI program, there was no differential change in the proportion of highly frail patients at BPCI vs control hospitals. There were also no differential deleterious changes in payments or clinical outcomes for frail relative to nonfrail patients at BPCI vs non-BPCI hospitals. CONCLUSION: While frail patients had higher costs and worse outcomes in general, there was no evidence of changes in access or worsening clinical outcomes in BPCI hospitals for frail patients relative to the nonfrail in hospitals' first year of participation in the program. These findings may be reassuring for policy makers and clinical leaders. J Am Geriatr Soc 67:2245-2253, 2019.


Subject(s)
Frail Elderly/statistics & numerical data , Hospitals/statistics & numerical data , Medicare/economics , Patient Care Bundles/economics , Quality Improvement , Reimbursement Mechanisms/economics , Subacute Care/economics , Aged , Aged, 80 and over , Female , Follow-Up Studies , Hospitalization/economics , Hospitalization/trends , Humans , Male , Retrospective Studies , United States
10.
Am J Clin Nutr ; 110(1): 246-253, 2019 07 01.
Article in English | MEDLINE | ID: mdl-31152541

ABSTRACT

BACKGROUND: Findings on the effects of vitamin D on cognitive performance have been inconsistent and no clinical trials with detailed cognitive testing in healthy older adults have been reported. OBJECTIVES: We tested whether 2000 IU is superior to 800 IU vitamin D3/d for cognitive performance among relatively healthy older adults. DESIGN: We analyzed data on cognitive performance as the secondary outcome of a 2-y double-blind randomized controlled trial that originally investigated the effect of vitamin D3 on knee function and pain in seniors with osteoarthritis. Participants were randomly assigned to either 2000 or 800 IU vitamin D3/d. Capsules had identical appearances and taste. A total of 273 community-dwelling older adults aged ≥60 y were enrolled 6-8 wk after unilateral joint replacement. Inclusion required a baseline Mini Mental State Examination (MMSE) score of 24. We implemented a detailed 2-h cognitive test battery. The primary cognitive endpoint was the score achieved in the MMSE. Secondary endpoints included a composite score of 7 executive function tests, auditory verbal and visual design learning tests, and reaction times. RESULTS: At baseline, mean age was 70.3 y, 31.4% were vitamin D-deficient [25(OH)D <20 ng/mL], and mean ± SD MMSE score was 28.0 ± 1.5. Although the mean ± SD 25(OH)D concentrations achieved differed significantly between treatment groups at 24-mo follow-up (2000 IU = 45.1 ± 10.2 ng/mL; 800 IU = 37.5 ± 8.8 ng/mL; P < 0.0001), none of the primary or secondary endpoints of cognitive performance differed between treatment group. Results by treatment were similar for predefined subgroups of baseline 25(OH)D status (deficient compared with replete) and age (60-69 y compared with ≥70 y). CONCLUSIONS: Our study does not support a superior cognitive benefit of 2000 IU compared with 800 IU vitamin D/d among relatively healthy older adults over a 24-mo treatment period. This trial was registered at clinicaltrials.gov as NCT00599807.


Subject(s)
Cholecalciferol/administration & dosage , Cognition/drug effects , Aged , Dietary Supplements , Dose-Response Relationship, Drug , Double-Blind Method , Female , Humans , Male , Memory/drug effects , Middle Aged , Osteoarthritis, Knee/drug therapy , Osteoarthritis, Knee/physiopathology , Pain/drug therapy , Reaction Time/drug effects , Vitamin D/analogs & derivatives , Vitamin D/blood , Vitamin D Deficiency/drug therapy , Vitamin D Deficiency/physiopathology
11.
BMJ Qual Saf ; 28(11): e1, 2019 11.
Article in English | MEDLINE | ID: mdl-30257883

ABSTRACT

BACKGROUND: Inter-hospital transfer (IHT, the transfer of patients between hospitals) occurs regularly and exposes patients to risks of discontinuity of care, though outcomes of transferred patients remains largely understudied. OBJECTIVE: To evaluate the association between IHT and healthcare utilisation and clinical outcomes. DESIGN: Retrospective cohort. SETTING: CMS 2013 100 % Master Beneficiary Summary and Inpatient claims files merged with 2013 American Hospital Association data. PARTICIPANTS: Beneficiaries≥age 65 enrolled in Medicare A and B, with an acute care hospitalisation claim in 2013 and 1 of 15 top disease categories. MAIN OUTCOME MEASURES: Cost of hospitalisation, length of stay (LOS) (of entire hospitalisation), discharge home, 3 -day and 30- day mortality, in transferred vs non-transferred patients. RESULTS: The final cohort consisted of 53 420 transferred patients and 53 420 propensity-score matched non-transferred patients. Across all 15 disease categories, IHT was associated with significantly higher costs, longer LOS and lower odds of discharge home. Additionally, IHT was associated with lower propensity-matched odds of 3-day and/or 30- day mortality for some disease categories (acute myocardial infarction, stroke, sepsis, respiratory disease) and higher propensity-matched odds of mortality for other disease categories (oesophageal/gastrointestinal disease, renal failure, congestive heart failure, pneumonia, renal failure, chronic obstructivepulmonary disease, hip fracture/dislocation, urinary tract infection and metabolic disease). CONCLUSIONS: In this nationally representative study of Medicare beneficiaries, IHT was associated with higher costs, longer LOS and lower odds of discharge home, but was differentially associated with odds of early death and 30 -day mortality depending on patients' disease category. These findings demonstrate heterogeneity among transferred patients depending on the diagnosis, presenting a nuanced assessment of this complex care transition.


Subject(s)
Chronic Disease/mortality , Patient Transfer/statistics & numerical data , Aged , Aged, 80 and over , Cohort Studies , Female , Hospitals , Humans , Length of Stay , Male , Medicare , Propensity Score , Retrospective Studies , Treatment Outcome , United States/epidemiology
12.
BMJ Qual Saf ; 27(12): 954-964, 2018 12.
Article in English | MEDLINE | ID: mdl-30126891

ABSTRACT

BACKGROUND: Unintentional discrepancies across care settings are a common form of medication error and can contribute to patient harm. Medication reconciliation can reduce discrepancies; however, effective implementation in real-world settings is challenging. METHODS: We conducted a pragmatic quality improvement (QI) study at five US hospitals, two of which included concurrent controls. The intervention consisted of local implementation of medication reconciliation best practices, utilising an evidence-based toolkit with 11 intervention components. Trained QI mentors conducted monthly site phone calls and two site visits during the intervention, which lasted from December 2011 through June 2014. The primary outcome was number of potentially harmful unintentional medication discrepancies per patient; secondary outcome was total discrepancies regardless of potential for harm. Time series analysis used multivariable Poisson regression. RESULTS: Across five sites, 1648 patients were sampled: 613 during baseline and 1035 during the implementation period. Overall, potentially harmful discrepancies did not decrease over time beyond baseline temporal trends, adjusted incidence rate ratio (IRR) 0.97 per month (95% CI 0.86 to 1.08), p=0.53. The intervention was associated with a reduction in total medication discrepancies, IRR 0.92 per month (95% CI 0.87 to 0.97), p=0.002. Of the four sites that implemented interventions, three had reductions in potentially harmful discrepancies. The fourth site, which implemented interventions and installed a new electronic health record (EHR), saw an increase in discrepancies, as did the fifth site, which did not implement any interventions but also installed a new EHR. CONCLUSIONS: Mentored implementation of a multifaceted medication reconciliation QI initiative was associated with a reduction in total, but not potentially harmful, medication discrepancies. The effect of EHR implementation on medication discrepancies warrants further study. TRIAL REGISTRATION NUMBER: NCT01337063.


Subject(s)
Health Care Surveys , Medication Errors/prevention & control , Medication Reconciliation , Quality Improvement , Academic Medical Centers , Adult , Cohort Studies , Electronic Health Records , Evidence-Based Medicine , Female , Hospitalization/statistics & numerical data , Hospitals, Community , Hospitals, Veterans , Humans , Male , Medication Errors/statistics & numerical data , Middle Aged , Multivariate Analysis , Poisson Distribution , Retrospective Studies , United States
13.
PLoS One ; 13(8): e0195476, 2018.
Article in English | MEDLINE | ID: mdl-30070989

ABSTRACT

OBJECTIVE: The objective of this study was to identify risk factors for 30-day readmission events for American Indian patients with diabetes in the southwest. RESEARCH DESIGN AND METHODS: Data from patients with diabetes admitted to Gallup Indian Medical Center between 2009 and 2016 were analyzed using logistic regression analyses. RESULTS: Of 2,660 patients, 394 (14.8%) patients had at least one readmission within 30 days of discharge. Older age (OR (95% CI) = 1.26, (1.17, 1.36)), longer length of stay (OR (95% CI) = 1.01, (1.0001, 1.0342)), and a history of substance use disorder (OR (95% CI) = 1.80, (1.25, 2.60)) were risk factors for 30-day readmission. An American Indian language preference was protective against readmission. CONCLUSIONS: Readmission events are complex and may reflect broad and interwoven disparities in community systems. Future research should work to support community-defined interventions to address both in hospital and external factors that impact risk factors for readmission.


Subject(s)
Diabetes Mellitus/ethnology , Indians, North American/statistics & numerical data , Patient Readmission/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Diabetes Mellitus/epidemiology , Female , Geography , Humans , Infant , Infant, Newborn , Length of Stay/statistics & numerical data , Male , Middle Aged , Patient Discharge/statistics & numerical data , Residence Characteristics/statistics & numerical data , Retrospective Studies , Risk Factors , Time Factors , Young Adult
14.
Glob Public Health ; 13(12): 1796-1806, 2018 12.
Article in English | MEDLINE | ID: mdl-29532733

ABSTRACT

Growing evidence suggests that health aid can serve humanitarian and diplomatic ends. This study utilised the Fragile States Index (FSI) for the 47 nations of the World Health Organizations' Africa region for the years 2005-2014 and data on health and non-health development aid spending from the United States (US) for those same years. Absolute amounts of health and non-health aid flows from the US were used as predictors of state fragility. We used time-lagged, fixed-effects multivariable regression modelling with change in FSI as the outcome of interest. The highest quartile of US health aid per capita spending (≥$4.00 per capita) was associated with a large and immediate decline in level of state fragility (b = -7.57; 95% CI, -14.6 to -0.51, P = 0.04). A dose-response effect was observed in the primary analysis, with increasing levels of spending associated with greater declines in fragility. Health per-capita expenditures were correlated with improved fragility scores across all lagged intervals and spending quartiles. The association of US health aid with immediate improvements in metrics of state stability across sub-Saharan Africa is a novel finding. This effect is possibly explained by our observations that relative to non-health aid, US health expenditures were larger and more targeted.


Subject(s)
Diplomacy , Health Policy , International Cooperation , Public Health , Social Conditions , Africa South of the Sahara , Global Health , Health Expenditures , Humans , Retrospective Studies , United States
15.
Am J Drug Alcohol Abuse ; 44(2): 200-205, 2018.
Article in English | MEDLINE | ID: mdl-28806102

ABSTRACT

BACKGROUND: Problem drinking carries significant health burdens, including an increased risk of hypertension. The effect of chronic alcohol intake on blood pressure (BP) in women is understudied and poorly understood. OBJECTIVES: We sought to examine the relationships between drinking habits and BP in hypertensive women. METHODS: We analyzed drinking habits in 113 women followed in the Brigham and Women's Hospital Hypertension Clinic for at least one year. RESULTS: Among these women with well-controlled hypertension, baseline diastolic BP was significantly lower in moderate drinkers compared with women who rarely or never drank. Changes in both systolic and diastolic BP over 12 months showed a significant negative association with changes in percent drinking days. In contrast, there was a trend toward higher baseline systolic BP among those women who consumed more drinks per drinking day. CONCLUSIONS: Among these women with controlled hypertension, our data failed to demonstrate an association between drinking beyond recommended limits and higher disease burden. These findings parallel the widely reported difference between drinking frequency, associated with a host of positive health outcomes, and drinking intensity, associated with negative outcomes. Novel to this report is an observed reduction in blood pressure over the one-year follow-up period accompanying an increased drinking frequency in treated hypertensive women. Cautions include the suggestion that a greater number of drinks per drinking day was associated with higher baseline pressure. These data imply that drinking within sensible limits has no negative impact on chronic hypertension. In fact, for women with well-controlled hypertension, such a habit may impart benefit.


Subject(s)
Alcohol Drinking/physiopathology , Blood Pressure/physiology , Hypertension/physiopathology , Female , Humans , Middle Aged
16.
J Healthc Qual ; 40(5): 292-300, 2018.
Article in English | MEDLINE | ID: mdl-29252871

ABSTRACT

INTRODUCTION: Despite the increased emphasis on patient experience, little is known about whether there are meaningful differences in hospital satisfaction between Hispanic and non-Hispanic whites. METHODS: To determine if satisfaction differs, we used Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey data (2009-2010) reported by hospitals to compare responses between Hispanic and non-Hispanic white patients. Clustered logistic regression models identified within-hospital and between-hospital differences in satisfaction. RESULTS: Of the 3,864,938 respondents, 6.2% were Hispanics, who were more often younger and females and less likely to have graduated from high school. Hispanics were overall more likely to recommend their hospital (74.1% vs. 70.9%, p < .001) and to rate it 9 or 10 (72.5% vs. 65.9%, p < .001) than whites. Increased satisfaction among Hispanics was more pronounced when compared with whites within the same hospitals, with significantly higher ratings on all HCAHPS measures. However, hospitals serving a higher percentage of Hispanics had lower satisfaction scores for both Hispanic and white patients than other hospitals. CONCLUSION: There were significant but only modest-sized differences in patient experience between Hispanic and white patients across U.S. hospitals. Hispanics tended to be more satisfied with their care but received care at lower-performing hospitals.


Subject(s)
Hispanic or Latino/statistics & numerical data , Hospitals/statistics & numerical data , Patient Satisfaction/ethnology , Patient Satisfaction/statistics & numerical data , Quality of Health Care/statistics & numerical data , White People/statistics & numerical data , Adult , Aged , Aged, 80 and over , Female , Humans , Logistic Models , Male , Middle Aged , Patient Reported Outcome Measures , Surveys and Questionnaires , United States
17.
Gen Hosp Psychiatry ; 36(6): 716-20, 2014.
Article in English | MEDLINE | ID: mdl-25312277

ABSTRACT

OBJECTIVE: To identify the patient characteristics associated with frequent emergency department (ED) use and develop a tool to predict risk for returning in the next month. METHOD: Prospective cohort study of 863 adults with psychiatric illness presenting to one of four general hospital EDs. ED visits and relevant clinical information in the year before and one month after the index visit were abstracted. RESULTS: One hundred sixty-seven of the patients (19%) were considered frequent users. Characteristics associated with frequent user status were homelessness, cocaine-positive toxicology screen, Medicare insurance, a personality disorder and hepatobiliary disease (all P<.05). Patients scoring in the highest risk category had nearly five times the odds of returning to the ED in the month subsequent to the index visit. CONCLUSIONS: Psychiatric patients with frequent ED use are a heterogeneous group, but there are specific target conditions which, if confirmed, may facilitate reduced ED use and be replaced by more appropriate treatment.


Subject(s)
Emergency Service, Hospital/statistics & numerical data , Mental Disorders/epidemiology , Adult , Female , Humans , Male , Massachusetts/epidemiology , Middle Aged , Prognosis , Prospective Studies
18.
Psychiatr Serv ; 63(3): 283-6, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22267250

ABSTRACT

OBJECTIVE: This study identified characteristics of adult psychiatric patients who remained for 24 or more hours in the emergency departments of general hospitals in Massachusetts. METHODS: Data were collected starting in June 2008 on a prospective cohort of 1,076 patients who presented for emergency psychiatric evaluation at one of five hospitals. RESULTS: A total of 90 patients (8%) stayed 24 or more hours (median=31 hours). More than 90% (N=1,018) of all patients had health insurance. Characteristics associated with extended stays included homelessness, transfer to another hospital, public insurance, and use of restraints or sitters (p<.05). The two academic medical centers had higher proportions of extended-stay patients than the three community hospitals (12% and 15% versus 1%, 7%, and 7%, respectively; p<.001). CONCLUSIONS: Despite overall high rates of health insurance coverage, publicly insured patients waited longer than those with private insurance. Future reforms of Massachusetts' mandatory health insurance program should consider treatment capacity as well.


Subject(s)
Emergency Service, Hospital/statistics & numerical data , Health Services Accessibility/statistics & numerical data , Length of Stay/statistics & numerical data , Mental Disorders/epidemiology , Adult , Aggression , Cohort Studies , Emergency Service, Hospital/organization & administration , Female , Ill-Housed Persons/statistics & numerical data , Humans , Insurance, Health , Male , Massachusetts , Mental Disorders/therapy , Middle Aged , Patient Transfer , Suicidal Ideation , Time Factors
19.
J Patient Saf ; 7(3): 122-6, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21738072

ABSTRACT

BACKGROUND: : Acute myocardial infarction, breast cancer, and colorectal cancer are among the most commonly misdiagnosed conditions in primary care, and there is little information regarding physician decision making in this area. METHODS: : We measured clinician risk tolerance and stress from uncertainty among 193 primary care clinicians and determined their association with management of patients presenting with chest pain (n = 700), breast lumps (n = 630), or rectal bleeding (n = 470). We used the 6-item Jackson Personality Inventory (JPI) and the 13-item Stress from Uncertainty Scale (SUS). Extended evaluation was defined as performance of electrocardiogram, cardiac stress testing, or emergency department triage for patients with chest pain; mammography, ultrasound, or surgical referral for patients with breast lumps; and colonoscopy or gastroenterology referral for patients with rectal bleeding. We fit multivariable logistic regression models to determine the association between survey scores and performance of extended evaluation. RESULTS: : The response rate was 79% for the JPI survey and 73% for the SUS survey. The mean JPI score was 8.9 (SD, 4.5) and the mean SUS score was 32.6 (SD, 10.4). Extended evaluation occurred for 60% of patients with chest pain, 93% of patients with breast lumps, and 63% of patients with rectal bleeding. Scores in JPI and SUS were not associated with rates of extended evaluation. CONCLUSIONS: : Primary care clinician risk tolerance and stress from uncertainty were not associated with evaluation decisions. Future research is needed to improve the consistency of evaluations to improve ambulatory patient safety.


Subject(s)
Attitude of Health Personnel , Diagnosis, Differential , Primary Health Care , Risk , Stress, Psychological/psychology , Adult , Breast Neoplasms/diagnosis , Colorectal Neoplasms/diagnosis , Decision Making , Diagnostic Techniques and Procedures , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Patient Safety , Racial Groups , Triage , Uncertainty
20.
J Subst Abuse Treat ; 41(2): 105-14, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21489738

ABSTRACT

This is a randomized controlled trial of 511 eligible women treated for diabetes, hypertension, infertility, or osteoporosis on an outpatient basis to test the hypothesis that those randomized to a brief intervention (BI) will drink less than those in the control condition 12 months later. A secondary goal was to identify the characteristics associated with changes in drinking outcome. All 511 completed the initial alcohol assessment, and 96% completed the 12-month follow-up interview. Those receiving the BI also had 3- and 6-month interviews. Four outcomes were assessed: (a) mean drinks per drinking day, (b) percent drinking days, (c) binge episodes defined as four or more drinks per occasion, and (d) weeks of drinking exceeding the National Institute on Alcohol Abuse and Alcoholism sensible drinking limits. Overall, there were no differences in drinking outcome by treatment group. Characteristics associated with changes in drinking, however, were identified to provide possible direction for future investigation.


Subject(s)
Alcohol Drinking/epidemiology , Alcohol Drinking/prevention & control , Psychotherapy, Brief , Risk-Taking , Adult , Alcohol Drinking/metabolism , Alcohol Drinking/therapy , Boston , Central Nervous System Depressants/poisoning , Comorbidity , Data Collection , Diabetes Mellitus/epidemiology , Ethanol/poisoning , Female , Humans , Hypertension/epidemiology , Infertility/epidemiology , Interview, Psychological , Middle Aged , Osteoporosis/epidemiology , Time Factors , Treatment Outcome
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