ABSTRACT
Plasma concentrations of protein hormones (LH, FSH, prolactin) and steroid hormones (estradiol, progesterone, testosterone, cortisol) have been assayed during the follicular and luteal phase of the cycle in patients with benign cysts and endometrioid cysts of the ovaries. Endometrial estradiol and progesterone receptors were also examined in these patients in the midluteal phase. These studies described steroid and gonadotropic hormone secretion of both the luteal and follicular phase in the two populations, as well as steroid receptors of the secretory endometrium. The most serious abnormalities were found in the endometrium of the patients with endometrioid ovarian cysts. These disorders suggest their relationship with infertility in the patients with benign ovarian neoplasms.
Subject(s)
Endometrium/metabolism , Hormones/blood , Ovarian Cysts/blood , Ovarian Neoplasms/blood , Receptors, Estradiol/metabolism , Receptors, Progesterone/metabolism , Adult , DNA, Neoplasm/analysis , Endometrium/chemistry , Female , Humans , Menstrual Cycle/metabolism , Ovarian Cysts/chemistry , Ovarian Neoplasms/chemistry , Receptors, Estradiol/analysis , Receptors, Progesterone/analysisABSTRACT
Mammary and endometrial status was examined in 162 female patients with benign ovarian tumors and tumor-like formations. Abnormal changes were found in the brests of 69.1% of the patients, and in the endometrium of 33%. A study of the secretory endometrium in patients with benign ovarian tumors and endometrioid cysts by means of the measurement of estradiol and progesterone receptors, demonstrated definite intracellular changes concerning the transmission of an adequate hormonal signal in endometrial cells, in which with respect to mammary hyperplasia.
Subject(s)
Adenofibroma/complications , Endometrial Hyperplasia/etiology , Fibrocystic Breast Disease/etiology , Ovarian Cysts/complications , Ovarian Neoplasms/complications , Endometrial Hyperplasia/diagnosis , Female , Fibrocystic Breast Disease/diagnosis , HumansABSTRACT
The paramagnetic form of ribonucleotide reductase was detected by ESR method in human cervix tissues, especially in tumor ones. The magnetic relaxation rate was proved to be slower for this form than for that in normal animal tissues having a high level of proliferative activity or in Ehrlich tumor cells studied before.