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Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases.

Takahashi, Daisuke; Orihara, Yuki; Kitagawa, Saho; Kusakabe, Masayuki; Shintani, Takahiro; Oma, Yukako; Harata, Masahiko.

Biosci Biotechnol Biochem ; 81(8): 1557-1560, 2017 Aug.

Article in English | MEDLINE | ID: mdl-28532323

ABSTRACT

Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.

Subject(s)

Gene Expression Regulation, Fungal , Histones/genetics , SUMO-1 Protein/genetics , Saccharomyces cerevisiae Proteins/genetics , Saccharomyces cerevisiae/genetics , Ubiquitin/genetics , DNA Helicases/genetics , DNA Helicases/metabolism , G2 Phase Cell Cycle Checkpoints , Histones/metabolism , Mitosis , Proteasome Endopeptidase Complex/metabolism , Proteolysis , SUMO-1 Protein/metabolism , Saccharomyces cerevisiae/metabolism , Saccharomyces cerevisiae Proteins/metabolism , Ubiquitin/metabolism , Ubiquitin-Protein Ligases/genetics , Ubiquitin-Protein Ligases/metabolism

ABSTRACT

Subject(s)

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