ABSTRACT
BackgroundCOVID-19 could have even more dire consequences in refugees camps than in general populations. Bangladesh has confirmed COVID-19 cases and hosts almost 1 million Rohingya refugees from Myanmar with 600,000 concentrated in Kutupalong-Balukhali Expansion Site (age mean: 21 years, sd: 18 years, 52% female). Projections of the potential COVID-19 burden, epidemic speed, and healthcare needs in such settings are critical for preparedness planning. Methods and FindingsTo explore the potential impact of the introduction of SARS-CoV-2 in Kutupalong-Balukhali Expansion Site, we used a stochastic SEIR transmission model with parameters derived from emerging literature and age as the primary determinant of infection severity. We considered three scenarios with different assumptions about the transmission potential of SARS-CoV-2. From the simulated infections, we estimated hospitalizations, deaths, and healthcare needs expected, age-adjusted for the Kutupalong-Balukhali Expansion Site age distribution. Our findings suggest that a large-scale outbreak is likely after a single introduction of the virus into the camp with 61-92% of simulations leading to at least 1,000 people infected across scenarios. On average, in the first 30 days of the outbreak, we expect 18 (95% prediction interval (PI), 2-65), 54 (95% PI, 3-223), and 370 (95% PI, 4-1,850) people infected in the low, moderate, and high transmission scenarios, respectively. These reach 421,500 (95% PI, 376,300-463,500), 546,800 (95% PI, 499,300-567,000) and 589,800 (95% PI, 578,800-595,600) people infected in 12 months, respectively. Hospitalization needs exceeded the existing hospitalization capacity of 340 beds after 55-136 days between the low and high transmission scenarios. We estimate 2,040 (95% PI, 1,660-2,500), 2,650 (95% PI, 2,030-3,380), and 2,880 (95% PI, 2,090-3,830) deaths in the low, moderate and high transmission scenarios, respectively. Due to limited data at the time of analyses, we assumed that age was the primary determinant of infection severity and hospitalization. We expect that comorbidities and limited hospitalization and intensive care capacity may increase this risk, thus we may be underestimating the potential burden. ConclusionsOur findings suggest that a COVID-19 epidemic in a refugee settlement may have profound consequences, requiring large increases in healthcare capacity and infrastructure that may exceed what is currently feasible in these settings. Detailed and realistic planning for the worst-case in Kutupalong-Balukhali and all refugee camps worldwide must begin now. Plans should consider novel and radical strategies to reduce infectious contacts and fill health worker gaps while recognizing that refugees may not have access to national health systems. AUTHORS SUMMARYO_LSTWhy was this study done?C_LSTO_LIForcibly displaced populations, especially those who reside in settlements with high density, poor access to water and sanitation, and limited health services, are especially vulnerable to COVID-19. C_LIO_LIBangladesh, which has confirmed COVID-19 cases, hosts almost 900,000 Rohingya refugees from Myanmar in the Coxs Bazar district, approximately 600,000 of whom are concentrated in the Kutupalong-Balukhali Expansion Site. C_LIO_LIThe capacity to meet the existing health needs of this population is limited; an outbreak of COVID-19 within this population threatens to severely disrupt an already fragile situation. C_LIO_LIWe conducted this study to estimate the number of people infected, hospitalizations, and deaths that might occur in the Kutupalong-Balukhali Expansion Site to inform ongoing preparedness and response activities by the Bangladesh government, the United Nations agencies, and other national and international actors. C_LI O_LSTWhat did the researchers do and find?C_LSTO_LIUsing a dynamic model of SARS-CoV-2 transmission, we simulated how a COVID-19 outbreak could spread within the Expansion Site according to three possible transmission scenarios (high, moderate, and low). C_LIO_LIOur results suggest that a large-scale outbreak is very likely in this setting after a single infectious person enters the camp, with 0.5-91% of the population expected to be infected within the first three months and over 70-98% during the first year depending on the transmission scenario, should no effective interventions be put into place. C_LIO_LIHospitalization needs may exceed the existing hospitalization capacity of 340 beds after 55-136 days of introduction. C_LI O_LSTWhat do these findings mean?C_LSTO_LIA COVID-19 epidemic in a high population density refugee settlement may have profound consequences, requiring increases in healthcare capacity and infrastructure that exceed what is feasible in this setting. C_LIO_LIAs many of the approaches used to prevent and respond to COVID-19 in the most affected areas so far will not be practical in humanitarian settings, novel and untested strategies to protect the most vulnerable population groups should be considered, as well as innovative solutions to fill health workforce gaps. C_LI
