The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis.

BACKGROUND: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. METHODS: We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. MAIN OUTCOME MEASURES: Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. RESULTS: Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32-3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11-2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43-8.94, p <  0.001) was also observed in positive mothers. CONCLUSION: This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women.

Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.

Enfermedades emergentes e importadas diagnosticadas en el servicio de urgencias de un hospital de Madrid / Emerging and imported diseases diagnosed in the emergency department of a hospital in Madrid

Objetivo. Describir las características clínicas y epidemiológicas de los pacientes diagnosticados de malaria, dengue, zika y chikungunya en un servicio de urgencias hospitalario (SUH), así como el valor de diagnóstico de las técnicas de las que se disponen en el SUH. Método. Estudio descriptivo, observacional, en el que se incluyeron pacientes diagnosticados de enfermedades infecciosas tropicales a partir de pruebas solicitadas desde un SUH. Resultados. Se diagnosticaron cuatro casos de dengue, siete casos de zika, tres casos de malaria y dos casos de coinfección (malaria + dengue y malaria + chikungunya). Conclusiones. La mayoría de los pacientes valorados son varones, nativos de zonas endémicas. Aunque se realice un diagnóstico precoz de malaria, es necesario descartar coinfección por distintos arbovirus. Para estudio de virus zika, hay que solicitar una prueba de PCR en orina, además de serología y PCR en suero

Objectives. To describe the clinical and epidemiologic characteristics of patients diagnosed with malaria, dengue fever, and Zika or chikungunya virus infections in a hospital emergency department. To describe the usefulness of the department's diagnostic resources. Methods. Descriptive observational study of patients diagnosed with infectious tropical diseases on the basis of samples collected in the emergency department. Results. The department diagnosed 4 cases of dengue fever, 7 cases of Zika virus infection, 7 of malaria, and 2 concomitant infections (malaria plus dengue fever and malaria plus chikungunya infection). Conclusions. Most patients with these infections were males and natives of areas where the diseases were endemic. Even when malaria is diagnosed early, the possibility of concomitant infection by other arboviruses must be ruled out. Serology is necessary to rule out Zika virus infection; polymerase chain reaction testing of urine and serum should be included

Emerging and imported diseases diagnosed in the emergency department of a hospital in Madrid. / Enfermedades emergentes e importadas diagnosticadas en el servicio de urgencias de un hospital de Madrid.

OBJECTIVES: To describe the clinical and epidemiologic characteristics of patients diagnosed with malaria, dengue fever, and Zika or chikungunya virus infections in a hospital emergency department. To describe the usefulness of the department's diagnostic resources. MATERIAL AND METHODS: Descriptive observational study of patients diagnosed with infectious tropical diseases on the basis of samples collected in the emergency department. RESULTS: The department diagnosed 4 cases of dengue fever, 7 cases of Zika virus infection, 7 of malaria, and 2 concomitant infections (malaria plus dengue fever and malaria plus chikungunya infection). CONCLUSION: Most patients with these infections were males and natives of areas where the diseases were endemic. Even when malaria is diagnosed early, the possibility of concomitant infection by other arboviruses must be ruled out. Serology is necessary to rule out Zika virus infection; polymerase chain reaction testing of urine and serum should be included.

OBJETIVO: Describir las características clínicas y epidemiológicas de los pacientes diagnosticados de malaria, dengue, zika y chikungunya en un servicio de urgencias hospitalario (SUH), así como el valor de diagnóstico de las técnicas de las que se disponen en el SUH. METODO: . Estudio descriptivo, observacional, en el que se incluyeron pacientes diagnosticados de enfermedades infecciosas tropicales a partir de pruebas solicitadas desde un SUH. RESULTADOS: Se diagnosticaron cuatro casos de dengue, siete casos de zika, tres casos de malaria y dos casos de coinfección (malaria + dengue y malaria + chikungunya). CONCLUSIONES: . La mayoría de los pacientes valorados son varones, nativos de zonas endémicas. Aunque se realice un diagnóstico precoz de malaria, es necesario descartar coinfección por distintos arbovirus. Para estudio de virus zika, hay que solicitar una prueba de PCR en orina, además de serología y PCR en suero.