[Differentiated surgical treatment of arteriovenous malformations of cerebral hemispheres of small and middle sizes in the epilepsy-like type of clinical course].

Experience of 115 observations of surgical treatment of arteriovenous malformations of the big brain hemispheres, having small and middle size, and owing various clinical signs, was analyzed. In 36 patients the epilepsy-like type of clinical signs was noted. To all the patients surgical treatment was conducted, using microsurgical technologies or endovascular embolization. Differentiated approach for determination of optimal method of surgical treatment have permitted to achieve satisfactory result in 33 (91.6%) patients, suffering epilepsy-like type of clinical signs.

[Pharmacokinetic and dosimetric characteristics of new radiopharmaceutical based on complexes of 103Pd and albumin microspheres].

Results of the study of absorbed dose formed in organs and tissues of mice after administration of new therapeutic radiopharmaceutical on the base of 103Pd and albumin microspheres (MSA) are presented. Pharmacokinetic parameters of preparation distribution in the body of animals were experimentally determined and then absorbed doses were calculated using MCNP code for the developed mathematical model of mouse. It was shown that absorption of 103Pd-MSA in tumor, physical properties of 103Pd and daughter radionuclide 103mRh provide a targeted irradiation of tumor as compared with the adjusting tissues and critical organs. In administration to tumor muscle tissue of the leg of experimental animals after 15 days following the injection of 103Pd-MSA the accumulated absorbed dose was 15 times less than corresponding one in tumor. In a critical organ (kidneys) the accumulated absorbed dose was 20 times less than in tumor. The work performed as a stage of pre-clinical testing of the radiopharmaceutical.

[Craniocerebral trauma in children operated on earlier for hydrocephalus]. / Cherepno-mozgovaia travma u detei, ranee operirovannykh po povodu gidrotsefalii.

The specific features of the clinical manifestations, diagnosis, management of brain injury are considered in 48 patients earlier anastomosed for progressive hydrocephalus. The leading features are mild focal neurological disorders, prevalent overall cerebral disturbances and no dislocational manifestations. These features are associated with the absence of hypertensive phenomena due to the presence of a drainage system and morphological substrate in children suffering from hydrocephalus, which affects the outcome of brain injury and its treatment.

[Around the Semipalatinsk proving grounds: the radioecological situation and the population radiation doses in Semipalatinsk Province (based on data from the report of the Interdepartmental Commission)]. / Vokrug Semipalatinskogo poligona: radioékologicheskaia obstanovka, dozy oblucheniia naseleniia v Semipalatinskoi oblasti (po materialam otcheta mezhvedomstvennoi komissii).

The paper represents some results of a joint commission, organized by the USSR Ministry of Health by order of the USSR Council of Ministers at public requests. The commission worked in the area neighbouring the proving ground at Semipalatinsk in the period of May-July 1988. A radiological situation there was investigated after underground nuclear testing on July 8, 1989. The results of measurements and archive data were used to estimate doses of radiation exposure of the population in the period of 1949 (nuclear testing on the ground and in the atmosphere) and in the period of underground testing, It was shown that in the period of 1949-1963 approximately 10,000 people received increased doses of external and internal irradiation. A high level of radiation-induced chromosome aberrations was noted among them. The highest effective equivalent doses of external and internal irradiation were received by the residents in the villages of Folon' (1.6 Gy during the first testing in 1949), Karaul (0.37 Gy), Sarzhal (0.20 Gy), Semenovka (0.02 Gy). The annual effective equivalent doses at that period did not exceed 0.0056 Gy (the highest value) for the Semipalatinsk residents. Proceeding from the values of collective doses probable long-term effects (malignant tumors) were assessed. Recommendations and conclusions of the commission are presented.