[Therapy of psoriasis]. / Terapia della psoriasi

The possible methods of treating psoriasis and results obtained are reviewed and the superior effectiveness of an approach reported in recent literature, an association of methoxalene per os and broad ultraviolet rays, is pointed out. In almost all cases submitted to such "photochemotherapeutic" treatment, regression of diffused lesions was rapid and complete with no systemic toxic effects or secondary skin alterations. On the basis of recent personal experience, it is stated that similar results may be obtained by the photochemotherapy of psoriasis with appropriate doses of Trisoralen per os and sunlight.

[Treatment of psoriasis (author's transl)]. / Therapie der psoriasis

From an examination of all possible methods for the treatment of psoriasis and the therapeutic results obtained with them, the author emphasizes the outstanding efficacy of a method for the treatment of psoriasis only recent described in the medical literature, which consists of a combination of methoxsalen by mouth and longwave ultraviolet light. In almost all cases treated with this "photochemotherapy" a rapid and complete regression of the extensive psoriasis lesions could, in fact, be observed without being able to detect toxic systemic side effects or secondary alterations of the skin. As a result of a recent trial of his own, the author points out that the results of photochemotherapy of psoriasis can equally well be obtained with "Trisoralen" by mouth and sunlight.

[Ultrastructural observations on amastigote forms of Leishmania donovani in a case of laryngeal leishmaniasis]. / Osservazioni ultrastrutturali sull'amastigote di Leishmania donovani in un caso di leishmaniosi laringea

An ultrastructural study on the amastigote stage of Leishmania donovani, in a rare case of laringeal involvement, was carried out. Many details of the fine morphology of this protozoon were observed under the electron microscope, i.e.: the outer membrane of host origin, periplast, subpellicular microtubules, kinetoplast, flagellum, flagellar pocket, multivesicular bodies. A presence of a new organelle (4 microtubules structure close to and running parallel to the flagellar pocket), previously not described in Leishmania donovani's species, was demonstrated in this indigenous strain (from Central Italy). The Authors found a limited number of subpellicular microtubules in this strain, i.e.: 72 microtubules. Differences in size and number of microtubules between strains must be investigated in more rigorous morphometric studies. It's possible that the number of the subpellicular microtubules represents a new taxonomic character.