ABSTRACT
Isolated arteritis of the central nervous system (CNS) is a relatively rare condition. Of the patients treated at our department two presented with characteristic features and eventually the diagnosis of isolated arteritis of the CNS was established. Headaches and relapsing lesions of cerebral nerves were predominant in the clinical picture of the first patient. In agreement with the clinical picture suggesting that small arteries were affected, the angiographic (AG) finding was negative and the diagnosis was based mainly on the positive effect of immunosuppressive treatment. The second patient with relapsing monofocal brain damage had a typical AG finding and a positive response to the treatment. The clinical picture of isolated arteritis of the CNS can be rather varied, with headaches and different neurological features being predominant. Both AG and bioptic examinations may prove negative. Positive response to immunosuppressive treatment is to be considered a characteristic feature of the disease. (Fig. 3, Ref. 11.)
Subject(s)
Arteritis , Cerebral Arterial Diseases , Adult , Arteritis/diagnosis , Arteritis/therapy , Cerebral Arterial Diseases/diagnosis , Cerebral Arterial Diseases/therapy , Female , Humans , MaleSubject(s)
Cerebrospinal Fluid/cytology , Ischemic Attack, Transient/cerebrospinal fluid , Acute Disease , Female , Humans , Male , Middle AgedSubject(s)
Myotonia Congenita/diagnosis , Adolescent , Adult , Female , Humans , Male , Myotonia Congenita/genetics , SyndromeABSTRACT
A peculiar grouping of Creutzfeldt-Jacob disease (CJD) and of other organic presenile dementia (OPD) cases in a small, prevalently rural area in Czechoslovakia to the east of 19 degrees 35' E and to the north of 48 degrees 15' N was studied. Between August, 1972 and November, 1976, three histologically proven CJD cases, bearing no sporadic of familial patterns, were observed. The distance between their dwellings was 13--17 km. In addition, seven cases of OPD were detected in the same area, two of them being suspected as possible CJD according to clinical evidence.
Subject(s)
Creutzfeldt-Jakob Syndrome/epidemiology , Dementia/epidemiology , Adult , Czechoslovakia , Dementia/etiology , Female , Humans , Male , Middle Aged , Time FactorsABSTRACT
Histopathological findings in three temporo-spatially linked cases of Creutzfeldt-Jakob disease (CJD) are reported. The patients were males, unrelated and without positive family history. Their mean age at the onset of the disease was 52.3 years. The mean duration of the illness was 6.6 months; the clinical symptomatology differed considerably. Neurohistology revealed in all patients a neuronal loss, intracyoplasmic vacuolation, spongiosis and astrocytosis. Besides the cortical regions, basal ganglia and cerebella were severely affected. All cases were pathologically suggestive of the cortico-striato-cerebella variant of CJD. Attention is drawn to this apparent topical similarity of most pronounced lesions. The possible significance of the pathoanatomical consistency, observed in the cases studied, for the unusual pattern of natural occurrence of CJD is considered.
Subject(s)
Cerebellum/pathology , Cerebral Cortex/pathology , Corpus Striatum/pathology , Creutzfeldt-Jakob Syndrome/pathology , Pons/pathology , Astrocytes/pathology , Demyelinating Diseases , Humans , Male , Middle Aged , Neurons/pathology , Purkinje Cells/pathologyABSTRACT
Groups of volunteers given intramuscularly 5 or 6.5 dex or perorally 6.5 dex newborn mouse icLD50 of the plaquesegregated "14" clone of the Langat E5 virus strain (tick-borne encephalitis comples) were followed for periods of 12 and 24-27 months. Circulating specific virus neutralizing antibodies persisted in them in the absence of apparent reaction as evidenced by clinical, electroencephalographic and cerebrospinal fluid findings.
Subject(s)
Antibodies, Viral/biosynthesis , Arboviruses/immunology , Encephalitis Viruses, Tick-Borne/immunology , Vaccines, Attenuated , Viral Vaccines , Administration, Oral , Adult , Cerebrospinal Fluid Proteins/analysis , Female , Humans , Immunization , Immunoglobulin G/cerebrospinal fluid , Immunoglobulin M/cerebrospinal fluid , Injections, Intramuscular , Male , Middle Aged , Time FactorsABSTRACT
A total of 22 persons, given a single intramuscular dose of 3.1 times 10(6) newborn mouse ic LD50/ml of the E5"14" virus (stored for 26 months at 4 degrees C in lyophilized state), were subjected to rigorous clinical, clinical-laboratory and virological investigations. Clinical observations and laboratory tests (blood and cerebrospinal fluid cytology and biochemistry) revealed no ill-effects or deviations attributable to the immunization procedure. After administration of the immunizing dose, no viraemia was detected and specific seroconversions from negativity to positivity were found after 9 weeks in 73-82% of the subjects, using different tick-borne encephalitis (western subtype) viruses in the virus neutralization experiments. The results obtained seem to give increased confidence in the further use of this attenuated virus clone with strictly defined characteristics.
