1.
Bioorg Med Chem Lett
; 14(8): 1913-6, 2004 Apr 19.
Article
in English
| MEDLINE
| ID: mdl-15050626
ABSTRACT
A series of N-acridin-9-yl-butane-1,4-diamines were found to be high-affinity ligands of the alpha(2)delta subunit of voltage gated calcium channels. The SAR studies of butane-1,4-diamine side chain resulted in the identification of compound 10 (IC(50)=9 nM), which is more potent than gabapentin (IC(50)=27 nM). Partial saturation of the acridine ring was also pursued and provided a compound with higher binding affinity than 1.