ABSTRACT
El gen MSX-1 es un miembro de la familia de genes homeobox MSX que cumple múltiples funciones durante el proceso de organogénesis. Este gen es expresado en sitios donde son requeridas interacciones epitelio-mesénquima y parece tener una función importante en el control del desarrollo craneofacial y dental, como lo demuestran los múltiples estudios en ratones y humanos. Este artículo revisa diferentes estudios con el objetivo de identificar las interacciones fisiológicas y patológicas de MSX-1 durante los diferentes estadíos de desarrollo craneofacial y dental.
MSX-1 gene is a member of the MSX homeobox gene family and it has different functions during the organogenesis process. This homeobox gene is expressed in sites where epithelium-mesenchyme interactions are required. It also seems to have an important activity controlling dental and craniofacial development, as investigated in human and murine models. The following article reviews severasl studies in order to identify MSX.1 relationships with dental and craniofacial development.
Subject(s)
Rats , Genes, Homeobox , Anodontia , Apoptosis/genetics , Cell Cycle , Cell Death , Cleft Palate , Odontogenesis , Cell Physiological PhenomenaABSTRACT
BACKGROUND: Lingual thyroid is a rare developmental anomaly originating from aberrant embryogenesis during descent of the gland from its site of origin, the foramen caecum, to its eutopic location. OBJECTIVE: We present the case of a 30-year-old female with a history of dysphagia and pharyngeal foreign body sensation over the past 12 months, associated with hypothyroidism. METHODS: Diagnostic and therapeutic approaches are discussed. RESULTS: Diagnosis of lingual thyroid was made and transoral thyroidectomy was performed as procedure-of-choice. Microscopic analysis revealed normal thyroid tissue with abundant colloid. The patient had an uneventful recovery and was discharged 2 days after surgery. Gamma-gram with Tc99m was scheduled for postoperative follow-up. CONCLUSIONS: Transoral lingual thyroidectomy followed by life-long hormonal therapy is the appropiate approach for patients with severe symptoms due to lingual thyroid hypertrophy associated with hypothyroidism.
