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1.
Front Public Health ; 12: 1342460, 2024.
Article in English | MEDLINE | ID: mdl-38947344

ABSTRACT

Introduction: Tobacco consumption and its impact on health remain high worldwide. Additionally, it is a contentious issue generating significant controversy. Twitter has proven to be a useful platform for evaluating public health topics related to population health behaviors, and tobacco consumption. Objective: The objective of this study is to analyze the content of tweets related to tobacco. Moreover, geolocation data will be considered to understand regional differences. Methods: Tweets published between 2018 and 2022, in both English and Spanish, containing the keyword "tobacco," were analyzed. A total of 56,926 tweets were obtained. The tweets were classified into different categories. 550 tweets were manually analyzed, and an automated and computerized classification was performed for the remaining and largest subset of tweets. Results: The analysis yielded 30,812 classifiable tweets. Healthcare professionals were the most frequent contributors to the topic (50.2%), with the most common theme being general information about the toxic effects of tobacco. 57.9% of the tweets discussed the harmful effects of tobacco on health, with fear being the predominant emotion. The largest number of tweets were located in America. Conclusions: Our study revealed a substantial number of tweets highlighting the health risks and negative perceptions of tobacco consumption. Africa showed the lowest percentage of tweets discussing the health risks associated with tobacco, coinciding with the continent having the least developed anti-tobacco policies. Healthcare professionals emerged as the most prominent users discussing the topic, which is encouraging as they play a crucial role in disseminating accurate and scientific health information.


Subject(s)
Social Media , Tobacco Use , Humans , Social Media/statistics & numerical data , Tobacco Use/epidemiology
2.
JCO Glob Oncol ; 10: e2300474, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38870436

ABSTRACT

PURPOSE: This study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala. METHODS: The Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is the only hospital in Central America dedicated exclusively to childhood and adolescent cancer. To address the regional need for specialists, a fellowship program in pediatric hematology/oncology was launched in 2003. The UNOP fellowship program comprises 3 years of training. Although the program is based at UNOP, it also includes rotations locally and internationally to enhance clinical exposure. The curriculum is based on international standards to cover clinical expertise, research, professionalism, communication, and health advocacy. Trainees are selected according to country or facility-level need for pediatric hematologists/oncologists, with a plan for them to be hired immediately after completing their training. RESULTS: Forty physicians from 10 countries in Latin America have completed training. In addition, there are currently 13 fellows from five countries in training. Of the graduates, 39 (98%) are now practicing in pediatric hematology/oncology in Latin America. Moreover, many of them have leadership positions within their institutions and participate in research, advocacy, and policy making. Graduates from the UNOP program contribute to institutions by providing care for an increasing number of patients with pediatric cancer. The UNOP program is the first pediatric hematology/oncology fellowship program in the world to be accredited by Accreditation Council for Graduate Medical Education-International, an international body accrediting clinical training programs. CONCLUSION: The UNOP program has trained specialists to increase the available care for children with cancer in Latin America. This regional approach to specialist training can maximize resources and serve as a model for other programs and regions.


Subject(s)
Fellowships and Scholarships , Hematology , Medical Oncology , Pediatrics , Humans , Guatemala , Hematology/education , Fellowships and Scholarships/organization & administration , Medical Oncology/education , Pediatrics/education , Child , Adolescent , Neoplasms , Female
3.
Front Public Health ; 12: 1346268, 2024.
Article in English | MEDLINE | ID: mdl-38655525

ABSTRACT

Background: The COVID-19 pandemic has had a multifaceted impact on maternal and child services and adversely influenced pregnancy outcomes. This systematic review aims to determine the impact of the COVID-19 pandemic on access to and delivery of maternal and child healthcare services in low- and middle-income countries. Methods: The review was reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A primary search of electronic databases was performed using a combination of search terms related to the following areas of interest: "impact' AND 'COVID-19' AND 'maternal and child health services' AND 'low- and middle-income countries. A narrative synthesis approach was used to analyse and integrate the results. Results: Overall, 45 unique studies conducted across 28 low- and middle-income countries met the inclusion criteria for the review. The findings suggest the number of family planning visits, antenatal and postnatal care visits, consultations for sick children, paediatric emergency visits and child immunisation levels decreased compared to the pre-pandemic levels in the majority of included studies. An analytical framework including four main categories was developed based on the concepts that emerged from included studies: the anxiety of not knowing (1), overwhelmed healthcare systems (2), challenges perceived by healthcare professionals (3) and difficulties perceived by service users (4). Conclusion: The COVID-19 pandemic disrupted family planning services, antenatal and postnatal care coverage, and emergency and routine child services. Generalised conclusions are tentative due to the heterogeneity and inconsistent quality of the included studies. Future research is recommended to define the pandemic's impact on women and children worldwide and prepare healthcare systems for future resurgences of COVID-19 and potential challenges beyond. Systematic review registration: PROSPERO (CRD42021285178).


Subject(s)
COVID-19 , Developing Countries , Health Services Accessibility , Maternal-Child Health Services , Child , Female , Humans , Pregnancy , COVID-19/epidemiology , Health Services Accessibility/statistics & numerical data , Maternal-Child Health Services/statistics & numerical data , SARS-CoV-2
4.
Front Psychiatry ; 15: 1282026, 2024.
Article in English | MEDLINE | ID: mdl-38566955

ABSTRACT

Introduction: Cocaine abuse represents a major public health concern. The social perception of cocaine has been changing over the decades, a phenomenon closely tied to its patterns of use and abuse. Twitter is a valuable tool to understand the status of drug use and abuse globally. However, no specific studies discussing cocaine have been conducted on this platform. Methods: 111,508 English and Spanish tweets containing "cocaine" from 2018 to 2022 were analyzed. 550 were manually studied, and the largest subset underwent automated classification. Then, tweets related to cocaine were analyzed to examine their content, types of Twitter users, usage patterns, health effects, and personal experiences. Geolocation data was also considered to understand regional differences. Results: A total of 71,844 classifiable tweets were obtained. Among these, 15.95% of users discussed the harm of cocaine consumption to health. Media outlets had the highest number of tweets (35.11%) and the most frequent theme was social/political denunciation (67.88%). Regarding the experience related to consumption, there are more tweets with a negative sentiment. The 9.03% of tweets explicitly mention frequent use of the drug. The continent with the highest number of tweets was America (55.44% of the total). Discussion: The findings underscore the significance of cocaine as a current social and political issue, with a predominant focus on political and social denunciation in the majority of tweets. Notably, the study reveals a concentration of tweets from the United States and South American countries, reflecting the high prevalence of cocaine-related disorders and overdose cases in these regions. Alarmingly, the study highlights the trivialization of cocaine consumption on Twitter, accompanied by a misleading promotion of its health benefits, emphasizing the urgent need for targeted interventions and antidrug content on social media platforms. Finally, the unexpected advocacy for cocaine by healthcare professionals raises concerns about potential drug abuse within this demographic, warranting further investigation.

5.
J Affect Disord ; 351: 649-660, 2024 Apr 15.
Article in English | MEDLINE | ID: mdl-38290587

ABSTRACT

BACKGROUND: Severe mental disorders like Schizophrenia and related psychotic disorders (SRD) or Bipolar Disorder (BD) require pharmacological treatment for relapse prevention and quality of life improvement. Yet, treatment adherence is a challenge, partly due to patients' attitudes and beliefs towards their medication. Social media listening offers insights into patient experiences and preferences, particularly in severe mental disorders. METHODS: All tweets posted between 2008 and 2022 mentioning the names of the main drugs used in SRD and BD were analyzed using advanced artificial intelligence techniques such as machine learning, and deep learning, along with natural language processing. RESULTS: In this 15-year study analyzing 893,289 tweets, second generation antipsychotics received more mentions in English tweets, whereas mood stabilizers received more tweets in Spanish. English tweets about economic and legal aspects displayed negative emotions, while Spanish tweets seeking advice showed surprise. Moreover, a recurring theme in Spanish tweets was the shortage of medications, evoking feelings of anger among users. LIMITATIONS: This study's analysis of Twitter data, while insightful, may not fully capture the nuances of discussions due to the platform's brevity. Additionally, the wide therapeutic use of the studied drugs, complicates the isolation of disorder-specific discourse. Only English and Spanish tweets were examined, limiting the cultural breadth of the findings. CONCLUSION: This study emphasizes the importance of social media research in understanding user perceptions of SRD and BD treatments. The results provide valuable insights for clinicians when considering how patients and the general public view and communicate about these treatments in the digital environment.


Subject(s)
Antipsychotic Agents , Social Media , Humans , Lithium/therapeutic use , Sentiment Analysis , Anticonvulsants , Antipsychotic Agents/therapeutic use , Artificial Intelligence , Quality of Life
6.
Popul Stud (Camb) ; 78(1): 151-166, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38093442

ABSTRACT

The number of births varies by season. Research on birth seasonality has shown that women's season of birth somehow influences that of their children, but factors underlying the intergenerational transmission of birth seasonality remain unknown. With data from Spain and France, we analysed the possibility of transmission of birth season between generations, testing whether relatives tended to be born in the same season. Results indicated that there was an association-a similarity-between parents' and children's birth seasons, partially explaining the stability of seasonal patterns over time. This association also existed between parents' birth seasons. While parents' association is directly explained by an excess of marriages with spouses born in the same month, the overall association may be explained by two facts: different socio-demographic groups show differentiated birth patterns, and relatives share socio-demographic features. Birth season seems to be related to family characteristics, which should be controlled for when assessing birth-month effects on subsequent social/health outcomes.


Subject(s)
Family Characteristics , Marriage , Child , Humans , Female , Seasons , Spain/epidemiology , France/epidemiology
7.
J Clin Med ; 12(24)2023 Dec 06.
Article in English | MEDLINE | ID: mdl-38137604

ABSTRACT

Peritoneal metastasis (PM) is the primary pattern of metastasis for primary tumours of the appendix, ovary, and peritoneal mesothelioma [...].

8.
Eur Arch Otorhinolaryngol ; 280(12): 5267-5276, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37266755

ABSTRACT

PURPOSE: To analyze the psychometric properties of the Niigata Questionnaire (NPQ) for use in a European population with persistent postural-perceptual dizziness (PPPD). METHODS: Observational study included 140 patients with different vestibular conditions. Construct validity, internal consistency and concurrent validity were analyzed. Intra-class correlation coefficient (ICC), standard error of measurement (SEM) and minimal detectable change (MDC) were calculated. Receiver operating characteristic (ROC) curve was used to test diagnostic values. RESULTS: Of the 140 patients, 47 had a diagnosis of PPPD. Factorial analysis showed a single-factor structure and concurrent validity analysis showed strong correlations with other instruments. Cronbach alpha coefficients of 0.938 for the total score, 0.869 for the standing and gait subscale, 0.803 for the subscale of movements and 0.852 for the visual stimulation subscale were obtained. The reproducibility was substantial except for the standing subscale, which could be considered moderate. For the standing, movement and visual stimulation subscales and for the total score, the SEM was 3.27, 2.41, 2.50 and 6.63, respectively, and the MDC was 6.40, 4.72, 4.91 and 12.99, respectively. The NPQ total score showed an area under the curve (AUC) of 0.661, a sensitivity of 72.34 and a specificity of 55.91 for discriminating between PPPD and other vestibular disorders. CONCLUSIONS: The NPQ is feasible for use in a Western population and presents a uni-factorial structure, high internal consistency and strong correlation with other instruments. The reliability can be considered substantial. The NPQ has low accuracy in discriminating between subjects with or without PPPD.


Subject(s)
Dizziness , Vestibular Diseases , Humans , Dizziness/diagnosis , Reproducibility of Results , Vestibular Diseases/diagnosis , Psychometrics , Surveys and Questionnaires
9.
Front Bioeng Biotechnol ; 11: 1010679, 2023.
Article in English | MEDLINE | ID: mdl-37152658

ABSTRACT

Introduction: This study aimed to develop an individualized artificial intelligence model to help radiologists assess the severity of COVID-19's effects on patients' lung health. Methods: Data was collected from medical records of 1103 patients diagnosed with COVID-19 using RT- qPCR between March and June 2020, in Hospital Madrid-Group (HM-Group, Spain). By using Convolutional Neural Networks, we determine the effects of COVID-19 in terms of lung area, opacities, and pulmonary air density. We then combine these variables with age and sex in a regression model to assess the severity of these conditions with respect to fatality risk (death or ICU). Results: Our model can predict high effect with an AUC of 0.736. Finally, we compare the performance of the model with respect to six physicians' diagnosis, and test for improvements on physicians' performance when using the prediction algorithm. Discussion: We find that the algorithm outperforms physicians (39.5% less error), and thus, physicians can significantly benefit from the information provided by the algorithm by reducing error by almost 30%.

10.
Article in English | MEDLINE | ID: mdl-36498203

ABSTRACT

(1) Background: The global health crisis caused by the coronavirus disease (COVID-19) pandemic has led to extreme overloading of different public healthcare systems worldwide. The Spanish Public Healthcare System is one of them. This study aimed to conduct a comparative cost analysis to assess the impact of the COVID-19 pandemic on small- and medium-sized regional hospitals in Andalusia (Spain). (2) Methods: This comparative, multicentre, observational, and retrospective study was designed to perform a comparative cost analysis between the Alto Guadalquivir Health Agency (AGHA) and Poniente University Hospital (PUH), both of which belong to the Spanish Public Health System (PHS). The data included in this study corresponds to the total costs by area and year incurred by the 61,335 patients from both healthcare institutions (AGHA = 36,110; PUH = 25,225) in the areas of hospital emergency service (HES), hospitalisation, and intensive care unit (ICU), during the 24 months of the study period (from 1 January 2019 to 31 December 2020). (3) Results: The analysis results showed a significant increase in costs incurred in 2020 for HES relative to those incurred in 2019 for both AGHA (+14%; p < 0.003) and PUH (+36%; p = 0.002). Additionally, costs incurred for ICU increased significantly in 2020 relative to those incurred in 2019 for both AGHA (+30%; p = 0.003) and PUH (+46%; p = 0.002). Hospitalisation costs for AGHA also increased significantly (+9%; p < 0.012) in 2020 versus those obtained in 2019; however, no significant differences were found for PUH (+6%; p = 1) in the same period analysed. However, the number of patients treated in the areas of HES, hospitalisation, and ICU was significantly reduced throughout 2020 compared to 2019. (4) Conclusions: Our findings show that the costs incurred during 2020 in the regional hospitals of Andalusia (Spain) increased significantly in most of the parameters analysed relative to those incurred in the year before the pandemic (i.e., 2019).


Subject(s)
COVID-19 , Pandemics , Humans , Retrospective Studies , COVID-19/epidemiology , Spain/epidemiology , Health Care Costs , Hospitals, University
11.
Int. j interdiscip. dent. (Print) ; 15(1): 16-19, abr. 2022. tab, ilus
Article in English | LILACS | ID: biblio-1385242

ABSTRACT

ABSTRACT: Objective: To explore patient experience for non-surgical periodontal therapy using phenomenography. Methods: This qualitative study was performed in a postgraduate specialist training program in periodontics. Patients reported their experiences through in-depth interviews in order to recognize the impact of non-surgical periodontal therapy on their quality of life and their satisfaction. A homogeneous sampling procedure was used, establishing redundancy after the fifteenth interview. Interviews were audio recorded, transcribed and analyzed by three researchers who codified the answers into categories to determine the emerging topics. Results: The core emerging themes were: (i) lack of information about periodontal disease; (ii) experience during treatment; (iii) treatment implications; and (iv) clinician-patient relationship. Conclusions: Patients seem to have limited knowledge about periodontal diseases. Reasons for attendance mainly include bleeding gums, tooth mobility, and aesthetic problems. Therapy can generate pain, fear, and is considered invasive, whereas dentine hypersensitivity may occur post-operatively. Despite this, patients would be willing to undergo treatment again and were generally satisfied with the level of care and treatment received.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Periodontal Diseases , Periodontics , Periodontitis/therapy , Education, Dental, Graduate
12.
J Clin Med ; 11(2)2022 Jan 12.
Article in English | MEDLINE | ID: mdl-35054055

ABSTRACT

(1) Background: The large global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overloaded the public health systems and reduced the regular healthcare activity, leading to a major health crisis. The main objective of this study was to carry out a comparative evaluation of the healthcare activities in the hospitals of Eastern Andalusia, Spain. (2) Methods: In this study, an observational, multicentered, and retrospective approach was adopted to compare the healthcare activities of the Poniente Hospital (PH) and the Alto Guadalquivir Health Agency (AGHA). Data was collected over a period of 24 months, i.e., from 1 January 2019 to 31 December 2020, and the variables evaluated were: patients seen in the hospital emergency service (HES), X-ray tests performed, patients cited in outpatient consultations, surgical interventions performed, and patients included in the waiting list. (3) Results: The analysis of the above-mentioned variables revealed a significant reduction in the number of patients registered in 2020 at HES as compared to that in 2019 for both PH (p = 0.002) and AGHA (p < 0.001). Moreover, the number of surgical interventions in 2020 was significantly reduced from that in 2019 for both PH (p = 0.001) and AGHA (p = 0.009). Moreover, for PH (p < 0.001), a significant reduction was observed in the waiting list admissions in 2020 compared to that in 2019; however, no significant difference in the waiting list admissions between the years 2020 and 2019 was observed for AGHA (p = 0.446). In 2020, the number of teleconsultations was significantly increased from that in 2019 for both PH (p < 0.001) and AGHA (p = 0.006). (4) Conclusion: The analysis carried out indicates that in 2020, compared to 2019, healthcare activity was significantly reduced in most of the parameters included in this study.

13.
J Orthop Res ; 40(6): 1436-1445, 2022 06.
Article in English | MEDLINE | ID: mdl-34370331

ABSTRACT

Hallux abducto valgus (HAV) is a common musculoskeletal disorder that has been addressed surgically. Nevertheless, the manual therapy approach may play an important role in the management of this condition. The present study aimed to determine the effectiveness of global postural reeducation (GPR) in subjects with symptomatic mild to moderate HAV in static postural control, dynamic stability, and ankle dorsiflexion range of motion (DFROM). A total of 80 patients with mild to moderate symptomatic HAV were allocated to the intervention group (GPR) or control group (CG) (no treatment) for 8 weeks. Outcome measures were assessed at baseline at 4 and 8 weeks including static postural control (Romberg test), dynamic balance (Star Excursion Balance Test [SEBT]), and ankle DFROM (Weight-Bearing Lunge Test [WBLT]). No improvements were observed at 4 weeks, but there were improvements at 8 weeks in: static postural control mediolateral displacement (X) of center of pressure (CoP) in both eyes open (EO) and eyes closed (EC): XEO (t(36) = 2.892, p = .006, d = 0.67); XEC (t(68) = 2.280, p = .026, d = 054); and velocity (V) of CoP displacement: VEO (t(68) = 2.380, p = .020, d = 0.57); VEC (t(36) = 2.057, p = .047, d = 0.37). It were also improvements in: WBLT (t(36) = -2.869, p = .007, d = 0.54) and SEBT at three directions (anterior, ANT; posteromedial, PM; and posterolateral, PL): SEBT.ANT (t(36) = -2.292, p = .028, d = 0.23); SEBT.PM (t(36) = -4.075, p < .001, d = 0.43); SEBT.PL (t(62) = -3.506, p = .001, d = 0.34). The present study showed that GPR compared to the CG might be effective in enhancing ankle function including postural control, dynamic balance, and DFROM.


Subject(s)
Hallux , Joint Instability , Ankle , Ankle Joint , Humans , Postural Balance , Range of Motion, Articular
14.
Healthcare (Basel) ; 9(6)2021 May 29.
Article in English | MEDLINE | ID: mdl-34072426

ABSTRACT

The important role of postural stability in exercise performance has been determined by several authors. Despite this, few studies have analyzed the relationship between respiratory muscles' strength and postural stability in athletes. For this reason, the aim of this study was to investigate the relationship between postural stability and respiratory muscles' function in male soccer players. A case-control study was conducted over twenty-eight healthy men (18 soccer players; 10 non-athletes). Inspiratory muscle strength (MIP) and respiratory resistance (MVV) were obtained through a digital spirometer. Stability variables were obtained in standing position on a stabilometric platform and in open and closed eyes conditions. The area and length of the center of pressures and displacements in the X and Y range were analyzed. Pearson's coefficient was used to measure the linear correlation between MIP, MVV and stabilometric variables. In the soccer players' group, MIP and MIP % predictive were inversely correlated with length (r = -0.535 and r = -0.585; p < 0.05) and X range (r = -0.527 and r = -0.560; p < 0.05), whereas MVV was directly correlated with length (r = 0.606; p < 0.01) and Y range (r = 0.558; p < 0.05). Our results show that the greater the inspiratory muscle strength, the less displacement of the pressure center, while at higher respiratory rates there is greater displacement.

15.
Rev. cuba. med. gen. integr ; 36(4): e1291, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1156488

ABSTRACT

Introducción: La Organización Internacional para las Migraciones (OIM), reportó en 2018 244 millones de migrantes en el mundo, el 3,3 por ciento de la población mundial. De ellos, México es el segundo país expulsor con 13 000 000. El fenómeno migratorio y la salud guardan estrecha relación, debido a diversos factores de riesgo que influyen en lo personal y familiar. Objetivo: Identificar los factores de riesgo relacionados con la salud de las personas migrantes durante el proceso migratorio. Métodos: Estudio de investigación transversal, prospectivo, no comparativo. Se desarrolló de marzo de 2017 a diciembre de 2018, en la ciudad de Tijuana, Baja California, en seis instituciones de apoyo al migrante. El instrumento contó con 62 ítems. La muestra fue de 392 migrantes mexicanos de ambos sexos, mayores de 18 años, que migraron y vivieron en Estados Unidos y regresaron a México. Resultados: De los 392 migrantes, resultaron 96,3 por ciento hombres y 3,8 por ciento mujeres, el principal factor de migración fue el económico (76,3 por ciento); 92 por ciento salió sano de México; 31,4 por ciento adquirió una nueva adicción, principalmente cristal (9,4 por ciento) y marihuana (6,6 por ciento). El 11,2 por ciento regresó con alguna enfermedad crónica: 4,1 por ciento con hipertensión; 3,1 por ciento con diabetes mellitus tipo 2 y 1,8 por ciento con epilepsia. Conclusiones: Las etapas del proceso migratorio de tránsito y vivir en los Estados Unidos fueron las que generaron mayores riesgos a la salud, la primera por los accidentes y agresiones de terceras personas y la segunda vinculada a la adquisición de nuevas adicciones a sustancias ilegales(AU)


Introduction: The International Organization for Migration (IOM) reported, in 2018, 244 million migrants worldwide, 3.3 percent of the world population. Of these, Mexico is the second country of origin, accounting for 13 000 000. The migration phenomenon and health are closely related, due to various risk factors that influence the personal and familial aspects. Objective: To identify risk factors related to the health of migrants during the migration process. Methods: Cross-sectional, prospective and noncomparative research study carried out from March 2017 to December 2018, in the city of Tijuana, Baja California, at six institutions that support migrants. The instrument had 62 items. The sample consisted of 392 Mexican migrants of both sexes, over 18 years of age, who migrated to and lived in the United States, and returned to Mexico. Results: Of the 392 migrants, 96.3 percent were men and 3.8 percent were women. The main migration factor was the economic (76.3 percent). 92 percent left Mexico healthy, while 31.4 percent acquired a new addiction, mainly crystal meth[amphetamine] (9.4 percent) and marijuana (6.6 percent). 11.2 percent returned with any chronic disease: 4.1 percent, with hypertension; 3.1 percent, with type 2 diabetes mellitus; and 1.8 percent, with epilepsy. Conclusions: The stages of the immigration process of transit and living in the United States were those that generated the greatest health risks; the first, due to accidents and assaults by third parties and the second in association with the uptake of new addictions to illegal substances(AU)


Subject(s)
Humans , Male , Female , Health Status , Risk Factors , Emigration and Immigration , Epidemiology, Descriptive , Cross-Sectional Studies , Prospective Studies , Mexico
16.
Pharmaceutics ; 12(9)2020 Sep 14.
Article in English | MEDLINE | ID: mdl-32937793

ABSTRACT

Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundless possibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented. Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectious diseases and many other health issues.

17.
Brain Sci ; 10(10)2020 Sep 24.
Article in English | MEDLINE | ID: mdl-32987639

ABSTRACT

Migraine and tension-type headache (TTH) are the two most prevalent primary headache disorders (PHDs) that may involve visual and vestibular impairments, neck pain, and postural unsteadiness. The perception of visual verticality (VV) has been studied in patients diagnosed with PHD to assess balance disorders showing varying findings. Our study aimed to assess the VV perception in patients diagnosed with PHD in comparison to healthy controls. A systematic review with meta-analysis was carried out in PubMed MEDLINE, Scopus, WOS, CINAHL, and SciELO. The Cohen standardized mean difference (SMD) was used to estimate the differences between exposed and healthy controls. Seven studies with 816 participants were included. The quality of included studies, according to the Newcastle-Ottawa Scale (NOS), was moderate (mean score of 5.2). Patients diagnosed with PHD showed a moderate misperception of VV as assessed with the subjective visual vertical (SVV) test (SMD = 0.530; 95% CI = 0.225, 0.836; p < 0.001). Specifically, a misperception of the SVV was found in patients with migraine (SMD = 0.369; 95% CI = 0.1, 0.638; p = 0.007) and with TTH (SMD = 1.122; 95% CI = 0.540, 1.704; p < 0.001). This review shows a misperception of VV in patients with migraine and TTH when assessed with the SVV test, being higher in patients with TTH, although the THH sample size was low.

18.
Rev. cuba. med. gen. integr ; 36(3): e1171, jul.-set. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1138974

ABSTRACT

Introducción: La Organización Mundial de la Salud considera a la planificación familiar posparto como la principal intervención que salva la vida de madres e hijos, porque al favorecer periodos intergenésicos de dos o más años, reduce en 10 y 30 por ciento la mortalidad infantil y materna, respectivamente. Objetivo: Determinar los factores que influyen en el uso de métodos anticonceptivos post evento obstétrico. Métodos: Estudio descriptivo, observacional y transversal. Se estudiaron mujeres en edad reproductiva durante los meses de mayo y junio de 2018, en un centro de salud en la Ciudad de México. Participaron 136 mujeres quienes tenían hasta un máximo de once meses y 29 días posterior a evento obstétrico. Se elaboró un cuestionario de autoaplicación, anónimo, integrado por 21 preguntas. La información fue integrada en el programa SPSS V25, y analizada a través de estadística descriptiva e inferencial. Resultados: Se encontró correlación significativa entre el uso de métodos anticonceptivos post evento obstétrico y las variables: conocimiento de la pareja en el uso de método anticonceptivo (p < 0,000); escolaridad de la paciente (p < 0,020); área del centro de salud en la que recibió la consejería (p < 0,032) y número de relaciones sexuales mensuales (p < 0,038). Conclusiones: El estudio logró determinar cuatro factores que influyen en el uso de métodos anticonceptivos post evento obstétrico, los cuales, están relacionados directamente con el éxito o fracaso en la consejería para planificación familiar prenatal(AU)


Introduction: The World Health Organization considers postpartum family planning as the main intervention that saves the lives of mothers and children, because, by favoring intergenetic periods of two or more years, it reduces infant and maternal mortality by 10% and 30 percent, respectively. Objective: To determine the factors that influence the use of contraceptive methods after an obstetric event. Methods: Descriptive, observational and cross-sectional study. Women of reproductive age were studied during the months of May and June of 2018, at a health center in Mexico City. 136 women participated who had up to a maximum of eleven months and 29 days after an obstetric event. An anonymous self-application questionnaire was prepared, consisting of 21 questions. The information was integrated into the program SPSS version 25, and analyzed through descriptive and inferential statistics. Results: A significant correlation was found between the use of contraceptive methods after an obstetric event and the variables knowledge of the couple regarding the use of the contraceptive method (P<0.000), schooling of the patient (P<0.020), area of ​​the health center in which counseling was received (P<0.032), and number of monthly sexual relations (P<0.038). Conclusions: The study permitted to determine four factors that influence the use of contraceptive methods after an obstetric event, which are directly related to the success or failure of prenatal family planning counseling(AU)


Subject(s)
Humans , Contraception/methods , Sexuality , Postpartum Period , Reproductive Health/education , Epidemiology, Descriptive , Cross-Sectional Studies , Family Development Planning , Observational Study
19.
Cancer Epidemiol ; 68: 101791, 2020 10.
Article in English | MEDLINE | ID: mdl-32823056

ABSTRACT

BACKGROUND: Peru has a public health problem because of asbestos imports. We analyzed the mortality trends for mesothelioma in Peru and its provinces from 2005 to 2014 and estimated their relationship with the amount of asbestos imported previously. METHODS: We computed age-standardized mortality rates (ASMRs) per 100,000 population (direct method and SEGI world standard population reference), and the standardized mortality ratio (SMR). The relationship between the amount of asbestos imported annually along the period 1965-2010 and the number of mesothelioma deaths per year from 2005 to 2014 was estimated by log-linear Poisson regression models and Pearson correlation calculations. RESULTS: After correcting the number of deaths, Peru registered 428 cases (or 430 when corrected cases are rounded by sex) between 2005 and 2014. The highest ASMRs were in Arequipa and Callao (range: 0.40-0.41/100,000 population), followed by Huancavelica (0.36/100,000 population). This translates into approximately one death per each 68-111 of asbestos tons imported. The latency period for the higher level of positive correlation found was 8 years (r = 0.8). Male female sex ratio was lower in provinces such as Junin and Hunacavelica with geological asbestos risk. CONCLUSIONS: Two patterns of mesothelioma risk have been detected, occupational and environmental. During the 2002-2006 years, Peru increased the asbestos use. If crocidolite imports were also increased, this could be behind the 8 years latency period detected. Peru should boost strategies towards the total ban of all forms of asbestos.


Subject(s)
Asbestos/adverse effects , Carcinogens/toxicity , Mesothelioma/mortality , Occupational Exposure/adverse effects , Adolescent , Adult , Child , Child, Preschool , Female , Geography , Humans , Infant , Infant, Newborn , Male , Mesothelioma/epidemiology , Mesothelioma/etiology , Middle Aged , Peru/epidemiology , Prognosis , Survival Rate , Young Adult
20.
Trials ; 20(1): 487, 2019 Aug 09.
Article in English | MEDLINE | ID: mdl-31399143

ABSTRACT

BACKGROUND: The underlying mechanisms of non-specific chronic neck pain relapses are not clear, but they could be associated with a deficit and alteration of neck muscles propioception that play a decisive role in cervical joint position, motor control of the head, and postural stability. Numerous treatments for non-specific chronic neck pain have been described in the scientific literature. However, few studies analyze its influence on postural stability, since these alterations are not fully described, and various theories emerge about the reasons that cause it. Our primary aim is to analyze the differences in postural stability, pain, cervical disability, and the relation between them produced by a treatment based on manual therapy and another based on therapeutic exercise. METHODS: The short-term and mid-term changes produced by different therapies on subjects with non-specific chronic neck pain will be studied. The sample will be randomly divided into three groups: manual therapy, therapeutic exercise, and placebo. As dependent variables of the study, we will take (1) Overall Balance Index, measured through a dynamic stabilometric platform; (2) pain, based on the visual analog scale and the Pressure Pain Threshold; (3) cervical disability, through the neck disability index. The findings will be analyzed statistically considering a 5% significance level (p ≤ 0.05). DISCUSSION: Our study aims to provide knowledge about postural stability and its relationship with pain in subjects with non-specific chronic neck pain. Analyzing the results produced by different types of therapy will allow us to draw conclusions about the mechanisms, structural or central, that may elicit these alterations. TRIAL REGISTRATION: Brazilian Clinical Trials Registry, RBR-2vj7sw . Registered on 28 November 2018.


Subject(s)
Chronic Pain/therapy , Neck Pain/therapy , Randomized Controlled Trials as Topic , Adolescent , Adult , Double-Blind Method , Exercise Therapy/methods , Humans , Middle Aged , Musculoskeletal Manipulations/methods , Young Adult
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