ABSTRACT
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Subject(s)
Humans , Male , Syndrome , Pharmaceutical Preparations/administration & dosage , Pharmaceutical Preparations , Skin Tests/methods , Hepatitis/diagnosis , Drug Utilization/classification , Pharmaceutical Preparations/supply & distribution , Skin Tests/instrumentation , Hepatitis/complications , Drug Utilization/standardsSubject(s)
Ciprofloxacin/administration & dosage , Colistin/administration & dosage , Drug Hypersensitivity Syndrome/diagnosis , Eosinophils/immunology , Histamine Antagonists/administration & dosage , Keratinocytes/pathology , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Drug Hypersensitivity Syndrome/etiology , Female , Humans , Meropenem , Middle Aged , Necrosis , Remission Induction , Skin Tests , Thienamycins/administration & dosage , Thienamycins/adverse effects , Withholding TreatmentSubject(s)
Angioedema/diagnosis , Anticonvulsants/adverse effects , Chronic Pain/drug therapy , Drug Hypersensitivity/diagnosis , Urticaria/diagnosis , gamma-Aminobutyric Acid/analogs & derivatives , Administration, Oral , Aged , Angioedema/etiology , Angioedema/prevention & control , Anticonvulsants/administration & dosage , Chronic Pain/complications , Clinical Trials, Phase III as Topic , Drug Hypersensitivity/etiology , Drug Hypersensitivity/prevention & control , Female , Humans , Immunization/methods , Pregabalin , Synaptic Transmission/drug effects , Urticaria/etiology , Urticaria/prevention & control , gamma-Aminobutyric Acid/administration & dosage , gamma-Aminobutyric Acid/adverse effectsABSTRACT
We present a case of urticaria caused by antihistamines in a patient with nonsteroidal anti-inflammatory drug (NSAID) sensitivity. A 35-year-old man experienced, on 2 separate occasions, immediate generalized urticaria during treatment with ibuprofen and naproxen, respectively. A single-blind, placebo-controlled oral challenge (SBPCOC) with piroxicam was carried out, and resulted in urticaria and angioedema 3 hours later. Two hours after initial clinical resolution, the patient developed multiple wheals on the trunk and upper limbs. He described similar delayed reactions after oral antihistamine administration on previous occasions. SBPCOCs with acetaminophen and etoricoxib were performed, with good tolerance. Skin prick and patch tests with loratadine and cetirizine were negative. After an SBPCOC with loratadine, the patient developed generalized urticaria 90 minutes after intake. Tolerance to fexofenadine 180 mg was confirmed. We describe the first case of a possible new subset of antihistamine urticaria, and suggest calling this NSAID-sensitive antihistamine-induced urticaria/angioedema.