Subject(s)
COVID-19 , Pneumonia , Respiratory Distress Syndrome , Antibodies, Monoclonal, Humanized , China , Humans , Methylprednisolone , Pneumonia/drug therapy , Risk Factors , SARS-CoV-2ABSTRACT
We present a series of 12 patients with telaprevir-induced skin toxicity. Some patients presented eczematous lesion, while others presented nonscaling macular lesions that became more purpuric in the lower limbs. Seven of the 12 patients had skin lesions affecting more than 50% of the body surface area, but none had systemic manifestations. Oral corticosteroids, prescribed in 7 patients, produced symptomatic improvement, and the response to the antiviral treatment in these patients was good. The 3 biopsies performed showed a superficial perivascular dermatitis with foci of red cell extravasation. Monitoring is central to the management of skin reactions secondary to the protease inhibitors, as severe drug eruptions have been reported. Treatment is usually symptomatic. We describe 7 cases in which oral corticosteroids-whose use continues to be controversial -were administered as a last resort for the control of pruritus.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Antiviral Agents/adverse effects , Drug Eruptions/drug therapy , Oligopeptides/adverse effects , Prednisone/therapeutic use , Administration, Oral , Aged , Anti-Inflammatory Agents/administration & dosage , Antiviral Agents/therapeutic use , Drug Eruptions/etiology , Drug Eruptions/pathology , Drug Therapy, Combination , Eczema/chemically induced , Eczema/drug therapy , Emollients/therapeutic use , Female , HIV Infections/complications , Hepatitis B, Chronic/complications , Hepatitis C, Chronic/complications , Hepatitis C, Chronic/drug therapy , Histamine Antagonists/therapeutic use , Humans , Male , Middle Aged , Oligopeptides/therapeutic use , Prednisone/administration & dosage , Pruritus/drug therapy , Pruritus/etiology , Purpura/chemically induced , Purpura/drug therapyABSTRACT
El objetivo del presente estudio ha sido analizar las tendencias y los cambios habidos en las autoagresiones medicamentosas en el área de un hospital urbano durante los últimos seis años. Se ha realizado un registro retrospectivo de todos los pacientes atendidos en el servicio de urgencias de un hospital general con ingestas intencionadas de fármacos. Un total de 1.000 pacientes (607 mujeres y 393 hombres) fueron atendidos durante el período estudiado. La edad media de los pacientes fue de treinta y cinco años. Los medicamentos mayoritariamente empleados fueron las benzodiazepinas (841 pacientes), seguidas por los antidepresivos tricíclicos (152 pacientes). Ciento cincuenta y cuatro pacientes asociaron alcohol a los medicamentos. últimamente se aprecia un descenso en el uso de antidepresivos tricíclicos en favor de los inhibidores selectivos de la recaptación de serotonina. Otros fármacos que aparecen con relativa frecuencia asociados a las autólisis medicamentosas son el paracetamol, los AINE y los antipsiróticos (AU)
