Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Mol Cell Biochem ; 479(3): 525-537, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37103677

ABSTRACT

Studies investigating the association between IL-6/IL-6R axis and schizophrenia (SZ) susceptibility found inconsistent data. To reconcile the results, a systematic review followed by a meta-analysis was performed to assess the associations. This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of the literature was carried out in July 2022 using electronic databases PubMed, EBSCO, Science Direct, PsychInfo, and Scopus. Study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Fifty-eight studies were identified, including 4,200 SZ patients and 4,531 controls. Our meta-analysis results showed an increase of IL-6 levels in plasma, serum, or CSF and decreased IL-6R levels in serum in patients under treatment. Further studies are needed to better elucidate the correlation between the IL-6/IL-6R axis and the schizophrenia.


Subject(s)
Interleukin-6 , Receptors, Interleukin-6 , Schizophrenia , Humans , Interleukin-6/blood , Interleukin-6/cerebrospinal fluid , Interleukin-6/chemistry , Plasma , Schizophrenia/cerebrospinal fluid , Schizophrenia/metabolism , Receptors, Interleukin-6/blood , Receptors, Interleukin-6/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...