An essentially radiation-transparent body coil integrated with a patient rotation system for MR-guided particle therapy.

BACKGROUND: The pursuit of adaptive radiotherapy using MR imaging for better precision in patient positioning puts stringent demands on the hardware components of the MR scanner. Particularly in particle therapy, the dose distribution and thus the efficacy of the treatment is susceptible to beam attenuation from interfering materials in the irradiation path. This severely limits the usefulness of conventional imaging coils, which contain highly attenuating parts such as capacitors and preamplifiers in an unknown position, and requires development of a dedicated radiofrequency (RF) coil with close consideration of the materials and components used. PURPOSE: In MR-guided radiation therapy in the human torso, imaging coils with a large FOV and homogeneous B1 field distribution are required for reliable tissue classification. In this work, an imaging coil for MR-guided particle therapy was developed with minimal ion attenuation while maintaining flexibility in treatment. METHODS: A birdcage coil consisting of nearly radiation-transparent materials was designed and constructed for a closed-bore 1.5 T MR system. Additionally, the coil was mounted on a rotatable patient capsule for flexible positioning of the patient relative to the beam. The ion attenuation of the RF coil was investigated in theory and via measurements of the Bragg peak position. To characterize the imaging quality of the RF coil, transmit and receive field distributions were simulated and measured inside a homogeneous tissue-simulating phantom for various rotation angles of the patient capsule ranging from 0° to 345° in steps of 15°. Furthermore, simulations with a heterogeneous human voxel model were performed to better estimate the effect of real patient loading, and the RF coil was compared to the internal body coil in terms of SNR for a full rotation of the patient capsule. RESULTS: The RF coil (total water equivalent thickness (WET) ≈ 420 µm, WET of conductor ≈ 210 µm) can be considered to be radiation-transparent, and a measured transmit power efficiency (B1 +/ P $\sqrt {\mathrm{P}} $ ) between 0.17 µT/ W $\sqrt {\mathrm{W}} $ and 0.26 µT/ W $\sqrt {\mathrm{W}} $ could be achieved in a volume (Δz = 216 mm, complete x and y range) for the 24 investigated rotation angles of the patient capsule. Furthermore, homogeneous transmit and receive field distributions were measured and simulated in the transverse, coronal and sagittal planes in a homogeneous phantom and a human voxel model. In addition, the SNR of the radiation-transparent RF coil varied between 103 and 150, in the volume (Δz = 216 mm) of a homogeneous phantom and surpasses the SNR of the internal body coil for all rotation angles of the patient capsule. CONCLUSIONS: A radiation-transparent RF coil was developed and built that enables flexible patient to beam positioning via full rotation capability of the RF coil and patient relative to the beam, with results providing promising potential for adaptive MR-guided particle therapy.

A Review of Parallel Transmit Arrays for Ultra-High Field MR Imaging.

Parallel transmission (pTX) techniques are required to tackle a number of challenges, e.g., the inhomogeneous distribution of the transmit field and elevated specific absorption rate (SAR), in ultra-high field (UHF) MR imaging. Additionally, they offer multiple degrees of freedom to create temporally- and spatially-tailored transverse magnetization. Given the increasing availability of MRI systems at 7 T and above, it is anticipated that interest in pTX applications will grow accordingly. One of the key components in MR systems capable of pTX is the design of the transmit array, as this has a major impact on performance in terms of power requirements, SAR and RF pulse design. While several reviews on pTX pulse design and the clinical applicability of UHF exist, there is currently no systematic review of pTX transmit/transceiver coils and their associated performance. In this article, we analyze transmit array concepts to determine the strengths and weaknesses of different types of design. We systematically review the different types of individual antennas employed for UHF, their combination into pTX arrays, and methods to decouple the individual elements. We also reiterate figures-of-merit (FoMs) frequently employed to describe the performance of pTX arrays and summarize published array designs in terms of these FoMs.

The Potential of Iron Oxide Nanoparticle-Enhanced MRI at 7 T Compared With 3 T for Detecting Small Suspicious Lymph Nodes in Patients With Prostate Cancer.

BACKGROUND: Accurate detection of lymph node (LN) metastases in prostate cancer (PCa) is a challenging but crucial step for disease staging. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) enables distinction between healthy LNs and nodes suspicious for harboring metastases. When combined with MRI at an ultra-high magnetic field, an unprecedented spatial resolution can be exploited to visualize these LNs. PURPOSE: The aim of this study was to explore USPIO-enhanced MRI at 7 T in comparison to 3 T for the detection of small suspicious LNs in the same cohort of patients with PCa. MATERIALS AND METHODS: Twenty PCa patients with high-risk primary or recurrent disease were referred to our hospital for an investigational USPIO-enhanced 3 T MRI examination with ferumoxtran-10. With consent, they underwent a 7 T MRI on the same day. Three-dimensional anatomical and T2*-weighted images of both examinations were evaluated blinded, with an interval, by 2 readers who annotated LNs suspicious for metastases. Number, size, and level of suspicion (LoS) of LNs were paired within patients and compared between field strengths. RESULTS: At 7 T, both readers annotated significantly more LNs compared with 3 T (474 and 284 vs 344 and 162), with 116 suspicious LNs on 7 T (range, 1-34 per patient) and 79 suspicious LNs on 3 T (range, 1-14 per patient) in 17 patients. For suspicious LNs, the median short axis diameter was 2.6 mm on 7 T (1.3-9.5 mm) and 2.8 mm for 3 T (1.7-10.4 mm, P = 0.05), with large overlap in short axis of annotated LNs between LoS groups. At 7 T, significantly more suspicious LNs had a short axis <2.5 mm compared with 3 T (44% vs 27%). Magnetic resonance imaging at 7 T provided better image quality and structure delineation and a higher LoS score for suspicious nodes. CONCLUSIONS: In the same cohort of patients with PCa, more and more small LNs were detected on 7 T USPIO-enhanced MRI compared with 3 T MRI. Suspicious LNs are generally very small, and increased nodal size was not a good indication of suspicion for the presence of metastases. The high spatial resolution of USPIO-enhanced MRI at 7 T improves structure delineation and the visibility of very small suspicious LNs, potentially expanding the in vivo detection limits of pelvic LN metastases in PCa patients.

An investigation into the dependence of virtual observation point-based specific absorption rate calculation complexity on number of channels.

PURPOSE: This study aims to find a relation between the number of channels and the computational burden for specific absorption rate (SAR) calculation using virtual observation point-based SAR compression. METHODS: Eleven different arrays of rectangular loops covering a cylinder of fixed size around the head of an anatomically correct voxel model were simulated. The resulting Q-matrices were compressed with 2 different compression algorithms, with the overestimation fixed to a certain fraction of worst-case SAR, median SAR, or minimum SAR. The latter 2 were calculated from 1e6 normalized random excitation vectors. RESULTS: The number of virtual observation points increased with the number of channels to the power of 2.3-3.7, depending on the compression algorithm when holding the relative error fixed. Together with the increase in the size of the Q-matrices (and therefore the size of the virtual observation points), the total increase in computational burden with the number of channels was to the power of 4.3-5.7. CONCLUSION: The computational cost emphasizes the need to use the best possible compression algorithms when moving to high channel counts.

Performance and safety assessment of an integrated transmit array for body imaging at 7 T under consideration of specific absorption rate, tissue temperature, and thermal dose.

In this study, the performance of an integrated body-imaging array for 7 T with 32 radiofrequency (RF) channels under consideration of local specific absorption rate (SAR), tissue temperature, and thermal dose limits was evaluated and the imaging performance was compared with a clinical 3 T body coil. Thirty-two transmit elements were placed in three rings between the bore liner and RF shield of the gradient coil. Slice-selective RF pulse optimizations for B1 shimming and spokes were performed for differently oriented slices in the body under consideration of realistic constraints for power and local SAR. To improve the B1+ homogeneity, safety assessments based on temperature and thermal dose were performed to possibly allow for higher input power for the pulse optimization than permissible with SAR limits. The results showed that using two spokes, the 7 T array outperformed the 3 T birdcage in all the considered regions of interest. However, a significantly higher SAR or lower duty cycle at 7 T is necessary in some cases to achieve similar B1+ homogeneity as at 3 T. The homogeneity in up to 50 cm-long coronal slices can particularly benefit from the high RF shim performance provided by the 32 RF channels. The thermal dose approach increases the allowable input power and the corresponding local SAR, in one example up to 100 W/kg, without limiting the exposure time necessary for an MR examination. In conclusion, the integrated antenna array at 7 T enables a clinical workflow for body imaging and comparable imaging performance to a conventional 3 T clinical body coil.

Post-processing algorithms for specific absorption rate compression.

PURPOSE: Compression of local specific absorption rate (SAR) matrices is essential for enabling SAR monitoring and efficient pulse calculation in parallel transmission. Improvements in compression result in lower error margin and/or lower number of virtual observation points (VOPs). The purpose of this work is to introduce two algorithms for post-processing of already compressed VOP sets. One calculates individual overestimation matrices for the VOPs to reduce overestimation, the other identifies redundant VOPs. METHODS: The first algorithm was evaluated for VOP sets calculated for three different transmit arrays with either 8 or 16 channels. For each array, two different overestimation matrices were used to generate the VOP sets. Each post-processed VOP set was evaluated using one million random excitation vectors and the results compared to the VOP set before post-processing. The second algorithm was evaluated by utilizing the same random excitation vectors and comparing the results after removal of the redundant VOPs with the results before removal to verify that these were identical. RESULTS: The first algorithm reduced the mean overestimation by up to four fifths compared to the original set, while keeping the number of VOPs constant. The second algorithm decreased the number of VOPs generated by a compression with Eichfelder and Gebhardt's algorithm by more than 40% in 40% of the investigated cases and by more than 20% in 73% of the investigated cases. CONCLUSION: Two post-processing algorithms are presented that enhance previously compressed VOP sets by improving the accuracy per number of VOPs.

Performance analysis of integrated RF microstrip transmit antenna arrays with high channel count for body imaging at 7 T.

The aim of the current study was to investigate the performance of integrated RF transmit arrays with high channel count consisting of meander microstrip antennas for body imaging at 7 T and to optimize the position and number of transmit elements. RF simulations using multiring antenna arrays placed behind the bore liner were performed for realistic exposure conditions for body imaging. Simulations were performed for arrays with as few as eight elements and for arrays with high channel counts of up to 48 elements. The B1+ field was evaluated regarding the degrees of freedom for RF shimming in the abdomen. Worst-case specific absorption rate (SARwc ), SAR overestimation in the matrix compression, the number of virtual observation points (VOPs) and SAR efficiency were evaluated. Constrained RF shimming was performed in differently oriented regions of interest in the body, and the deviation from a target B1+ field was evaluated. Results show that integrated multiring arrays are able to generate homogeneous B1+ field distributions for large FOVs, especially for coronal/sagittal slices, and thus enable body imaging at 7 T with a clinical workflow; however, a low duty cycle or a high SAR is required to achieve homogeneous B1+ distributions and to exploit the full potential. In conclusion, integrated arrays allow for high element counts that have high degrees of freedom for the pulse optimization but also produce high SARwc , which reduces the SAR accuracy in the VOP compression for low-SAR protocols, leading to a potential reduction in array performance. Smaller SAR overestimations can increase SAR accuracy, but lead to a high number of VOPs, which increases the computational cost for VOP evaluation and makes online SAR monitoring or pulse optimization challenging. Arrays with interleaved rings showed the best results in the study.

Local SAR compression algorithm with improved compression, speed, and flexibility.

PURPOSE: Local specific absorption rate (SAR) compression algorithms are essential for enabling online SAR monitoring in parallel transmission. A better compression resulting in a lower number of virtual observation points improves speed of SAR calculation for online supervision and pulse design. METHOD: An iterative expansion of an existing algorithm presented by Lee et al is proposed in this work. The original algorithm is used within a loop, making use of the virtual observation points from the previous iteration as the starting subvolume, while decreasing the overestimation with each iteration. This algorithm is evaluated on the SAR matrices of three different simulated arrays. RESULT: The number of virtual observation points is approximately halved with the new algorithm, while at the same time the compression time is reduced with speed-up factors of up to 2.5. CONCLUSION: The new algorithm improves the original algorithm in terms of compression rate and speed.

Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance.

OBJECTIVE: In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance. METHOD: Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression. RESULT: Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20% at the cost of a higher absolute overestimation at high actual local SAR values. CONCLUSION: The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission.

Magnetic resonance imaging at ultra-high magnetic field strength: An in vivo assessment of number, size and distribution of pelvic lymph nodes.

OBJECTIVE: The definition of an in vivo nodal anatomical baseline is crucial for validation of representative lymph node dissections and accompanying pathology reports of pelvic cancers, as well as for assessing a potential therapeutic effect of extended lymph node dissections. Therefore the number, size and distribution of lymph nodes in the pelvis were assessed with high-resolution, large field-of-view, 7 Tesla (T) magnetic resonance imaging (MRI) with frequency-selective excitation. MATERIALS AND METHODS: We used 7 T MRI for homogeneous pelvic imaging in 11 young healthy volunteers. Frequency-selective imaging of water and lipids was performed to detect nodal structures in the pelvis. Number and size of detected nodes was measured and size distribution per region was assessed. An average volunteer-normalized nodal size distribution was determined. RESULTS: In total, 564 lymph nodes were detected in six pelvic regions. Mean number was 51.3 with a wide range of 19-91 lymph nodes per volunteer. Mean diameter was 2.3 mm with a range of 1 to 7 mm. 69% Was 2 mm or smaller. The overall size distribution was very similar to the average volunteer-normalized nodal size distribution. CONCLUSIONS: The amount of in vivo visible lymph nodes varies largely between subjects, whereas the normalized size distribution of nodes does not. The presence of many small lymph nodes (≤2mm) renders representative or complete removal of pelvic lymph nodes to be very difficult. 7T MRI may shift the in vivo detection limits of lymph node metastases in the future.

A 32-channel parallel transmit system add-on for 7T MRI.

PURPOSE: A 32-channel parallel transmit (pTx) add-on for 7 Tesla whole-body imaging is presented. First results are shown for phantom and in-vivo imaging. METHODS: The add-on system consists of a large number of hardware components, including modulators, amplifiers, SAR supervision, peripheral devices, a control computer, and an integrated 32-channel transmit/receive body array. B1+ maps in a phantom as well as B1+ maps and structural images in large volunteers are acquired to demonstrate the functionality of the system. EM simulations are used to ensure safe operation. RESULTS: Good agreement between simulation and experiment is shown. Phantom and in-vivo acquisitions show a field of view of up to 50 cm in z-direction. Selective excitation with 100 kHz sampling rate is possible. The add-on system does not affect the quality of the original single-channel system. CONCLUSION: The presented 32-channel parallel transmit system shows promising performance for ultra-high field whole-body imaging.

A multitransmit external body array combined with a 1 H and 31 P endorectal coil to enable a multiparametric and multimetabolic MRI examination of the prostate at 7T.

PURPOSE: In vivo 1 H and 31 P magnetic resonance spectroscopic imaging (MRSI) provide complementary information on the biology of prostate cancer. In this work we demonstrate the feasibility of performing multiparametric imaging (mpMRI) and 1 H and 31 P spectroscopic imaging of the prostate using a 31 P and 1 H endorectal radiofrequency coil (ERC) in combination with a multitransmit body array at 7 Tesla (T). METHODS: An ERC with a 31 P transceiver loop coil and 1 H receive (Rx) asymmetric microstrip (31 P/1 H ERC) was designed, constructed and tested in combination with an external 8-channel 1 H transceiver body array coil (8CH). Electromagnetic field simulations and measurements and in vivo temperature measurements of the ERC were performed for safety validation. In addition, the signal-to-noise (SNR) benefit of the 1 H microstrip with respect to the 8CH was evaluated. Finally, the feasibility of the setup was tested in one volunteer and three patients with prostate cancer by performing T2 -weighted and diffusion-weighted imaging in combination with 1 H and 31 P spectroscopic imaging. RESULTS: Electromagnetic field simulations of the 31 P loop coil showed no differences in the E- and B-fields of the 31 P/1 H ERC compared with a previously safety validated ERC without 1 H microstrip. The hotspot of the specific absorption rate (SAR) at the feed point of the 31 P/1 H ERC loop coil was 9.42 W/kg when transmitting on 31 P at 1 W. Additional in vivo measurements showed a maximum temperature increase at the SAR hotspot of 0.7°C over 6 min on 31 P at 1.9 W transmit (Tx) power, indicating safe maximum power levels. When transmitting with the external 1 H body array at 40W for 2:30 min, the temperature increase around the ERC was < 0.3°C. Up to 3.5 cm into the prostate the 1 H microstrip of the ERC provided higher SNR than the 8CH. The total coil combination allowed acquisition of an mpMRI protocol and the assessment of 31 P and 1 H metabolites of the prostate in all test subjects. CONCLUSION: We developed a setup with a 31 P transceiver and 1 H Rx endorectal coil in combination with an 8-channel transceiver external body array coil and demonstrated its safety and feasibility for obtaining multiparametric imaging and 1 H and 31 P MRSI at 7T in patients with prostate cancer within one MR examination.

USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience.

PURPOSE: To evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging of pelvic lymph nodes (LNs) at ultrahigh magnetic field strength. MATERIALS AND METHODS: The ethics review board approved this study and written informed consent was obtained from all patients. Three patients with rectal cancer and three selected patients with (recurrent) prostate cancer were examined at 7-T 24-36 h after intravenous ferumoxtran-10 administration; rectal cancer patients also received a 3-T MRI. Pelvic LN imaging was performed using the TIAMO technique in combination with water-selective multi-GRE imaging and lipid-selective GRE imaging with a spatial resolution of 0.66 × 0.66 × 0.66mm3. T2*-weighted images of the water-selective imaging were computed from the multi-GRE images at TE = 0, 8, and 14 ms and used for the assessment of USPIO uptake. RESULTS: High-resolution 7-T MR gradient-echo imaging was obtained robustly in all patients without suffering from RF-related signal voids. USPIO signal decay in LNs was visualized using computed TE imaging at TE = 8 ms and an R2* map derived from water-selective imaging. Anatomically, LNs were identified on a combined reading of computed TE = 0 ms images from water-selective scans and images from lipid-selective scans. A range of 3-48 LNs without USPIO signal decay was found per patient. These LNs showed high signal intensity on computed TE = 8 and 14 ms imaging and low R2* (corresponding to high T2*) values on the R2* map. CONCLUSION: USPIO-enhanced MRI of the pelvis at 7-T is technically feasible and offers opportunities for detecting USPIO uptake in normal-sized LNs, due to its high intrinsic signal-to-noise ratio and spatial resolution. KEY POINTS: • USPIO-enhanced MRI at 7-T can indicate USPIO uptake in lymph nodes based on computed TE images. • Our method promises a high spatial resolution for pelvic lymph node imaging.

Development and evaluation of a 16-channel receive-only RF coil to improve 7T ultra-high field body MRI with focus on the spine.

PURPOSE: A 16-channel receive (16Rx) radiofrequency (RF) array for 7T ultra-high field body MR imaging is presented. The coil is evaluated in conjunction with a 16-channel transmit/receive (16TxRx) coil and additionally with a 32-channel transmit/receive (32TxRx) remote body coil for RF transmit and serving as receive references. METHODS: The 16Rx array consists of 16 octagonal overlapping loops connected to custom-built detuning boards with preamplifiers. Performance metrics like noise correlation, g-factors, and signal-to-noise ratio gain were compared between 4 different RF coil configurations. In vivo body imaging was performed in volunteers using radiofrequency shimming, time interleaved acquisition of modes (TIAMO), and 2D spatially selective excitation using parallel transmit (pTx) in the spine. RESULTS: Lower g-factors were obtained when using the 16Rx coil in addition to the 16TxRx array coil configuration versus the 16TxRx array alone. Distinct signal-to-noise ratio gain using the 16Rx coil could be demonstrated in the spine region both for a comparison with the 16TxRx coil (>50% gain) in vivo and the 32TxRx coil (>240% gain) in a phantom. The 16Rx coil was successfully applied to improve anatomical imaging in the abdomen and 2D spatially selective excitation in the spine of volunteers. CONCLUSION: The novel 16-channel Rx-array as an add-on to multichannel TxRx RF coil configurations provides increased signal-to-noise ratio, lower g-factors, and thus improves 7T ultra-high field body MR imaging.

Feasibility of aortic valve planimetry at 7 T ultrahigh field MRI: Comparison to aortic valve MRI at 3 T and 1.5 T.

INTRODUCTION: This study examined the feasibility of aortic valve planimetry at 7 T ultrahigh field MRI in intraindividual comparison to 3 T and 1.5 T MRI. MATERIAL AND METHODS: Aortic valves of eleven healthy volunteers (mean age, 26.4 years) were examined on a 7 T, 3 T, and 1.5 T MR system using FLASH and TrueFISP sequences. Two experienced radiologists evaluated overall image quality, the presence of artefacts, tissue contrast ratios, identifiability, and image details of the aortic valve opening area (AVOA). Furthermore, AVOA was quantified twice by reader 1 and once by reader 2. Correlation analysis between artefact severity and employed magnetic field strength was performed by modified Fisher's exact-test. Paired t-test was used to analyse for AVOA differences, and Bland-Altman plots were used to analyse AVOA intra-rater and inter-rater variability. RESULTS: Aortic valve imaging at 7 T, 3 T, and 1.5 T with using FLASH was less hampered by artefacts than TrueFISP imaging at 3 T and 1.5 T. Tissue contrast and image details were rated best at 7 T. AVOA was measured slightly smaller at 7 T compared to 3 T (TrueFISP, p-value = 0.057; FLASH, p-value = 0.016) and 1.5 T (TrueFISP, p-value = 0.029; FLASH, p-value = 0.018). Intra-rater and inter-rater variability of AVOA tended to be slightly smaller at 7 T than at 3 T and 1.5 T. CONCLUSION: Aortic valve planimetry at 7 T ultrahigh field MRI is technically feasible and in healthy volunteers offers an improved tissue contrast and a slightly better reproducibility than MR planimetry at 1.5 T and 3 T.

7T ultra-high field body MR imaging with an 8-channel transmit/32-channel receive radiofrequency coil array.

PURPOSE: In this work, a combined body coil array with eight transmit/receive (Tx/Rx) meander elements and with 24 receive-only (Rx) loops (8Tx/32Rx) was developed and evaluated in comparison with an 8-channel transmit/receive body array (8Tx/Rx) based on meander elements serving as the reference standard. METHODS: Systematic evaluation of the RF array was performed on a body-sized phantom. Body imaging at 7T was performed in six volunteers in the body regions pelvis, abdomen, and heart. Coil characteristics such as signal-to-noise ratio, acceleration capability, g-factors, S-parameters, noise correlation, and B1+ maps were assessed. Safety was ensured by numerical simulations using a coil model validated by dosimetric field measurements. RESULTS: Meander elements and loops are intrinsically well decoupled with a maximum coupling value of -20.5 dB. Safe use of the 8Tx/32Rx array could be demonstrated. High gain in signal-to-noise ratio (33% in the subject's center) could be shown for the 8Tx/32Rx array compared to the 8Tx/Rx array. Improvement in acceleration capability in all investigations could be demonstrated. For example, the 8Tx/32Rx array provides lower g-factors in the right-left and anterior-posterior directions with R = 3 undersampling as compared to the 8Tx/Rx array using R = 2. Both arrays are very similar regarding their RF transmit performance. Excellent image quality in the investigated body regions could be achieved with the 8Tx/32Rx array. CONCLUSION: In this work, we show that a combination of eight meander elements and 24 loop receive elements is possible without impeding transmit performance. Improved SNR and g-factor performance compared to an RF array without these loops is demonstrated. Body MRI at 7T with the 8Tx/32Rx array could be accomplished in the heart, abdomen, and pelvis with excellent image quality.

Fast and accurate multi-channel B1+ mapping based on the TIAMO technique for 7T UHF body MRI.

PURPOSE: Current methods for mitigation of transmit field B1+ inhomogeneities at ultrahigh field (UHF) MRI by multi-channel radiofrequency (RF) shimming rely on accurate B1+ mapping. This can be time consuming when many RF channels have to be mapped for in vivo body MRI, where the B1 maps should ideally be acquired within a single breath-hold. Therefore, a new B1+ mapping technique (B1TIAMO) is proposed. METHODS: The performance of this technique is validated against an established method (DREAM) in phantom measurements for a cylindrical head phantom with an 8-channel transmit/receive (Tx/Rx) array. Furthermore, measurements for a 32-channel Tx/Rx remote array are conducted in a large body phantom and the |B1+| map reliability is validated against simulations of the transmit RF field distribution. Finally, in vivo results of this new mapping technique for human abdomen are presented. RESULTS: For the head phantom (8-channel Tx/Rx coil), the single |B1+| comparison between B1 TIAMO, the direct DREAM measurements, and simulation data showed good agreement with 10-19% difference. For the large body phantom (32-channel Tx/Rx coil), B1TIAMO matched the RF field simulations well. CONCLUSION: The results demonstrate the potential to acquire 32 accurate single-channel B1+ maps for large field-of-view body imaging within only a single breath-hold of 16 s at 7T UHF MRI. Magn Reson Med 79:2652-2664, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Parallel transmit capability of various RF transmit elements and arrays at 7T MRI.

PURPOSE: In this work, 22 configurations for remote radiofrequency (RF) coil arrays consisting of different transmit element designs for 7 Tesla (T) ultrahigh-field MRI are compared by numerical simulations. METHODS: Investigated transmit RF element types are rectangular loops, micro striplines, micro striplines with meanders, 250-mm shielded dipoles with meanders, and lambda over two dipoles with and without shield. These elements are combined in four different configurations of circumferential RF body arrays with four or eight transmit elements each. Comparisons included coupling behavior, degrees of freedom offered by the individual transmit patterns, and metrics like power and specific absorption rate efficiency. RESULTS: Coupling between neighboring RF elements is elevated (up to -7 dB) for all arrays with eight elements, whereas it is below -25 dB for arrays with only four elements. The cumulative sum of singular values points out highest degrees of freedom for the central transversal, reduced values in the central coronal, and minimum values in the sagittal slice. Concerning power and SAR efficiency, eight lambda over two dipoles are most advantageous. CONCLUSIONS: Among the investigated remote arrays and parameters, a combination of eight dipoles appears to be most favorable for potential use in 7T body MRI. Magn Reson Med 79:1116-1126, 2018. © 2017 International Society for Magnetic Resonance in Medicine.