ABSTRACT
Cutaneous melanoma (CM) is a disease with an unpredictable evolution mainly due to its high metastatic ability. The steadily increasing incidence and the poor outcome in advanced stages made this cancer an interesting field for many research groups. Given that CM is a curable disease in early stages, efforts have been made to detect it as soon as possible, which led to the diversification and refining of diagnosis methods and therapies. But, as the data from trials have been published, doubts about the indications and efficacy of established treatments have arisen. In fact, there is probably no single aspect of early CM that has not given birth to controversy. This article intends to present the current disputes regarding the early detection, diagnosis, treatment and postoperative follow-up of patients with localized CM. After analyzing both pros and cons, several conclusions were drawn, that reflect our experience in managing patients with early CM.
Subject(s)
Melanoma/diagnosis , Melanoma/therapy , Dermoscopy , Humans , Melanoma/pathology , Melanoma/surgery , Plastic Surgery Procedures , Sentinel Lymph Node Biopsy , Skin Neoplasms , Melanoma, Cutaneous MalignantABSTRACT
Transient reactive papulotranslucent acrokeratoderma (TRPA) is an unusual skin condition characterized by the rapid and transient development of symmetric, edematous white papules with eccrine duct prominence on the palms after exposure to water. We present the case of a 28-year-old woman diagnosed in our clinic with TRPA induced by the use of a non-steroidal anti-inflammatory drug. The possible pathophysiology and treatment options are discussed.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Keratoderma, Palmoplantar/chemically induced , Keratoderma, Palmoplantar/pathology , Water/adverse effects , Adult , Back Pain/drug therapy , Female , Humans , RomaniaABSTRACT
Koebner phenomenon represents the development of several inflammatory skin lesions (psoriasis, lichen planus, vitiligo, etc.) in uninvolved skin following various traumatic insults. The case of a 27-year-old male patient with scalp psoriasis who was referred to our clinic for generalized psoriatic lesions developed two weeks after tattooing his skin at the age of 18 was presented; the case illustrated the possibility of Koebner phenomenon induced by skin tattooing in patients with psoriasis.
Subject(s)
Psoriasis/etiology , Tattooing/adverse effects , Adult , Humans , Male , Psoriasis/pathology , Skin/pathologyABSTRACT
RATIONALE: Many treatments have been proposed for cosmetic or functional improvement of scars. It is known that fat grafts and laser treatment can have beneficial effects on the remodeling of scar tissue, and platelet-rich plasma (PRP) can be effective during the wound-healing process. We hypothesized that laser and PRP can enhance fat graft survival and the combination would be effective in improving scars appearance. OBJECTIVE: The purpose of this study was to evaluate the efficacy of these combinations in the treatment of atrophic and contractile scars. METHODS AND RESULTS: From 2008-2013, we treated with this combination 64 patients affected by atrophic and contractile scars involving different body parts. At 6 months the patients' overall satisfaction rate was excellent for over 50% of the patients. DISCUSSION: The association of an ablative laser CO2 with PRP and autologous fat graft seems to be a promising and effective therapeutic approach for atrophic and contractile scars. ABBREVIATIONS: PRP platelet-rich plasma, OTI orotracheal intubation, HLLT high level laser therapy, LLLT low level laser therapy.
