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Bioorg Med Chem Lett
; 18(4): 1402-6, 2008 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-18243691
ABSTRACT
This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.