ABSTRACT
A 68-year-old man, who had worked for processing quartz-containing stones for more than 50 years, complained of low-grade fever and arthralgia. Mediastinal lymph nodes were markedly swollen on chest computed tomography. Pathological findings of the lymph node were compatible with silicosis, with a high titer of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). During follow-up with prednisolone treatment, pleuritis and uveitis developed as manifestations of vasculitis. Thus, he was diagnosed with MPO-ANCA-associated vasculitis with occupational silica exposure, possibly microscopic polyangiitis (MPA). This case is rare, because pleuritis was the only pulmonary manifestation, without interstitial pneumonia, alveolar hemorrhage or glomerulonephritis.
Subject(s)
Microscopic Polyangiitis/etiology , Pleurisy/etiology , Silicon Dioxide/adverse effects , Silicosis/complications , Silicosis/diagnosis , Aged , Antibodies, Antineutrophil Cytoplasmic/blood , Glucocorticoids/therapeutic use , Humans , Lymphatic Diseases/etiology , Lymphatic Diseases/pathology , Male , Occupational Exposure , Peroxidase/immunology , Pleurisy/diagnostic imaging , Prednisolone/therapeutic use , Silicosis/drug therapy , Silicosis/immunology , Tomography, X-Ray Computed , Uveitis/etiologyABSTRACT
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the thymus is rare and little is known about its karyotype abnormality. MALT lymphoma in general shows a good prognosis, but some reports suggest that the presence of trisomy 18 predicts recurrence. Here, we report a patient with MALT lymphoma of the thymus and the left parotid gland accompanied by Sjogren's syndrome. The karyotype analysis revealed that this is the first case of thymic MALT lymphoma with trisomy 18, which we believe is worth reporting. We also review cases with thymic MALT lymphoma previously reported in the literature.
