Adsorption of viral particles from the blood plasma of patients with viral hepatitis on nanodiamonds.

Adsorption of viral particles from the blood plasma of patients with viral hepatitis B and C on modified nanodiamonds (MNDs) was shown in the in vitro experiments. PCR method showed the treatment of plasma with MNDs leads to a decrease in the viral load by 2-3 orders of magnitude or more in both cases studied. These results make it possible to predict the applicability of MNDs for the development of new technologies of hemodialysis and plasmapheresis for binding and removal of viral particles from the blood of infected patients.

[Effect of preparation "Korargin" on metabolic syndrome manifestations in adult and old rats exposed to x-ray irradiation].

Introduction to the diet of adult and old rats for 30 days after R-irradiation at a dose of 5 Gy drug "Korargin" prevented the development of some manifestations of radioinduced metabolic syndrome (MS) in animals of both age groups: in adult irradiated animals--a tendency to decrease insulin levels in blood plasma, increase of cholesterol levels in liver tissue, significantly increased serum high density lipoprotein as compared both to controls and irradiated animals, prevented the decrease in the levels of anions NO2- and NO3- in tissue of the aorta and anions NO2- in tissue of the heart; in old irradiated animals--prevented tended to increase of body weight, the increase in insulinresistance (index HOMA), the decrease in the level of anions NO2- in the aorta tissue, increased levels of anions NO2- and NO3- in the heart tissue compared to controls. Prevention through drug "Korargin" some manifestations of radioinduced MS in adult and old animals, indicates the prospects of exploring the possibility of correction of the violations of carbohydrate and lipid metabolism caused by exposure to ionizing radiation, in individuals of both age groups.

[Telomere elongation and prolongation of lifespan in rats by unblocking of telomere caps].

Telomeres are the ends of chromosomes and are non-coding DNA "end-capped" with structures containing DNA-quadruplexes and proteins. Telomeres become shorter after each cell division, which is one of the mechanisms of gradual ageing. Telomerase is the reverse transcriptase responsible for the extension of telomere length. It is well known that activation of telomerase in the most types of organism's cells is not enough for telomere length stabilization. The reason may be in the telomere "caps", which cover telomere ends from telomerase action. This experiment shows that telomeres were elongated by the combination of hypoxia activated telomerase and a newly developed pharmacological method removing the telomere cap when this combined method was applied to the human lymphocyte culture and the Wistar rats. Rats from the control group died at the age 1 year 7 month - 1 year 8 month, which is typical for the Wistar rats from our sub-line. Rats from the experimental group died at the age 2 year 4 month. The result Morris's labyrinth water test showed the better spatial memory function of rats passed the telomere stabilization therapy. The results of these experiments show the significant role of telomere stabilization therapy in prolongation of lifespan.

[Role of microorganisms in etiology and pathogenesis of aging].

This review demonstrates the theory of presumably main role of microorganisms as a trigger of well-known mechanisms of ageing. It is shown that latent and chronic infections may initiate and support processes of senescence, stimulating signs of ageing and age-related diseases.