1.
Vrach Delo
; (5): 53-5, 1991 May.
Article
in Russian
| MEDLINE
| ID: mdl-1866916
Subject(s)
Adjuvants, Immunologic/therapeutic use , Dipeptides , Peptides/therapeutic use , Thymus Extracts/therapeutic use , Thymus Hormones/therapeutic use , Tuberculosis/drug therapy , Animals , Drug Evaluation, Preclinical , Immune System/drug effects , Immune System/immunology , Immune System/pathology , Mice , Mice, Inbred CBA , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Tuberculosis/immunology , Tuberculosis/pathology
2.
Probl Tuberk
; (12): 52-4, 1991.
Article
in Russian
| MEDLINE
| ID: mdl-1803376
ABSTRACT
The effects of thymogen, thymalin and vilosen in combination with antituberculous drugs (isoniazid, streptomycin, rifampicin) were studied on 240 CBA mice with experimental tuberculosis. Thymus preparations supplemented to the complex treatment of experimental tuberculosis significantly increased their lifespan, contributed to a decrease in the index of spleen weight lung density and significantly increased the count of T lymphocytes and their proliferative activity as compared to those on antituberculous drugs alone. Thymogen was found to be the most effective in the complex treatment of experimental tuberculosis, whereas vilosen was the least. Thymogen plus vilosen proved to be the most beneficial combination of drugs.