ABSTRACT
Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
Subject(s)
Leukoplakia, Oral/drug therapy , Lichen Planus, Oral/drug therapy , Mouth Mucosa/pathology , Naphthoquinones/therapeutic use , Oral Ulcer/drug therapy , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Biopolymers/therapeutic use , Drugs, Chinese Herbal/therapeutic use , Female , Humans , Inflammation/drug therapy , Male , Methylcellulose/analogs & derivatives , Methylcellulose/therapeutic use , Middle AgedABSTRACT
Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.
Subject(s)
Epithelium/metabolism , Epithelium/pathology , Immunohistochemistry/methods , Lichen Planus/metabolism , Lichen Planus/pathology , Mouth Mucosa/metabolism , Mouth Mucosa/pathology , Female , Humans , In Vitro Techniques , Ki-67 Antigen/metabolism , Male , Middle AgedABSTRACT
Epidemiological survey of 1161 indigenous people (I group) and 1000 people came (II group) of the population of Far East in the age over than 20 years was conducted. Established that the deformation of dentitions at diagnosis was found in 22.13% I group, 20.1% II group, reduced occlusion in 15.84% (I group) and 11.0% (II group). Pathology of the TMJ was defined at 8.68% of men and 26.15% of women in group I, 8.24% men and 30.04% of women in group II.
Subject(s)
Dentition , Temporomandibular Joint Disorders/epidemiology , Tooth Diseases/epidemiology , Adult , Asia, Eastern/epidemiology , Female , Humans , Male , Middle Aged , Prevalence , Russia/epidemiology , Young AdultABSTRACT
Tobacco smoking causes pronounced structural reorganization of the gingival mucosa and its atrophic changes. Odontopreparation stimulates destructive processes in the gingival mucosa promoting activation of local immunity (stimulation of immunoglobulin synthesis). Significant differences in the local humoral immunity (IgG dysimmunoglobulinemia) and cytokine spectrum in nonsmoking and tobacco-smoking patients were detected. Subcompensated level of immune resistance in tobacco smokers prompts referring them to a group at a high risk of chronic pathological processes of the oral cavity.
Subject(s)
Mouth Mucosa/immunology , Mouth Mucosa/pathology , Smoking/immunology , Smoking/pathology , Adult , Antibody Formation , Cytokines/metabolism , Humans , Immunoglobulin A, Secretory/metabolism , Immunoglobulin G/metabolism , Male , Middle Aged , Orthodontics, Corrective/methodsABSTRACT
Autoradiographic examinations of gingival mucosa biopsy specimens obtained from 117 subjects aged 17 to 78 have demonstrated a higher intensity of the proliferation processes in females as against men. No age-specific differences in the proliferation parameters were revealed. These data may be useful in studies of the possible disorders of the proliferative processes in various abnormalities of the buccal mucosa.
Subject(s)
Gingiva/cytology , Mouth Mucosa/cytology , Adolescent , Adult , Aged , Aging , Autoradiography , Cell Division , Epithelial Cells , Female , Humans , Male , Middle Aged , Sex CharacteristicsSubject(s)
Alveolar Process/anatomy & histology , Dentures , Aging/metabolism , Alveolar Process/metabolism , Epithelium/anatomy & histology , Epithelium/metabolism , Gingiva/anatomy & histology , Gingiva/metabolism , Histocytochemistry , Humans , Mouth Mucosa/anatomy & histology , Mouth Mucosa/metabolismABSTRACT
The experiment with 24 dogs involved increase of their interalveolar space in the frontal section by 6 mm via fixation of metal crowns on 98 189 teeth. Follow-up of the masticatory muscle adaptation has shown that it ran a wave-like course. The most intensive shifts are observed on days 7-14 of the experiment, this being followed by a gradual recovery of this muscle tinctorial characteristics by the 20th day of the experiment; then the restructuring process stabilizes on a new structural and functional level by days 30-60 of the experiment. Complete morphologic restructuring of the masticatory muscle in response to increase of the interalveolar space takes more than 60 days. If a still more increase of this space is needed (more than 6 mm), it may be started not before 20-30 days after complete restructuring.
