ABSTRACT
A patient is reported with a form of epidermolysis bullosa, hitherto undescribed to the best of our knowledge, characterized by the slow centripetal progression of symmetrical blister formation, milia, scarring, atrophy, and nail dystrophy. Electron microscopy, immunofluorescence mapping, and KF-1 monoclonal antibody studies confirm this disease to be a form of dystrophic epidermolysis bullosa, probably of autosomal recessive transmission despite the absence of acral deformities, contractures, mucosal involvement, and growth retardation.
Subject(s)
Cicatrix/pathology , Epidermolysis Bullosa/pathology , Antibodies, Monoclonal , Cicatrix/physiopathology , Epidermolysis Bullosa/physiopathology , Female , Humans , Middle Aged , Skin/ultrastructureABSTRACT
The study of abnormal nails (onychopathology) can contribute considerably to the art of diagnostic medicine. Nail pigmentation is an important facet of onychopathology. Pigmentation abnormalities may suggest general disease and in some cases indicate a specific diagnosis. Their recognition may also be valuable in following the side effects of treatment.
Subject(s)
Nail Diseases/etiology , Pigmentation Disorders/etiology , Humans , Nail Diseases/diagnosis , Physical Examination , Pigmentation Disorders/diagnosisABSTRACT
The study of abnormal nails (onychopathology) can contribute considerably to the art of diagnostic medicine. Nail pigmentation is an important facet of onychopathology. Pigmentation abnormalities may suggest general disease and in some cases indicate a specific diagnosis. Their recognition may also be valuable in following the side effects of treatment.
Subject(s)
Nail Diseases/etiology , Pigmentation Disorders/etiology , Humans , Nail Diseases/diagnosis , Physical Examination , Pigmentation Disorders/diagnosisABSTRACT
The nail-patella syndrome has been of interest to dermatologists because the diagnosis of this multisystem complex may be suggested simply by observing the patient's abnormal nails. It is the purpose of this article to call attention to triangular lunulae and other nail abnormalities associated with this syndrome, as well as other causes of triangular lunulae.
Subject(s)
Nail-Patella Syndrome/diagnosis , Nails, Malformed/diagnosis , Adult , Female , Humans , Nail-Patella Syndrome/complications , Nail-Patella Syndrome/genetics , Nails, Malformed/complications , Psoriasis/complicationsSubject(s)
Dermatitis Herpetiformis/diagnosis , Pruritus/diagnosis , Scalp Dermatoses/diagnosis , Dermatitis Herpetiformis/immunology , Dermatitis Herpetiformis/pathology , HLA Antigens/analysis , Humans , Immunoglobulin A/analysis , Immunoglobulin M/analysis , Male , Middle Aged , Reticulin/immunologyABSTRACT
By judicious consideration of the clinical appearance, by direct examination with magnification, and by culture results, skin biopsy, and other laboratory results, the clinician is able to diagnose most pathological conditions of the scalp. The scalp participates in many systemic disorders and frequently is the chief site of involvement. Similarly, many generalized disorders limited to the skin exhibit their most typical manifestations in the scalp. Whenever a diagnosis eludes the investigator, more than likely he or she has not considered all of the etiological possibilities or has not pursued an adequate laboratory investigation. A few scalp diseases initially present nonspecific clinical pictures. By utilizing follow-up examinations at appropriate intervals, the diagnosis can eventually be made. Once a diagnosis is made, appropriate treatment will generally produce satisfactory improvement or cure. Nevertheless, a few generally rare conditions will defy the physician's most enlightened and aggressive therapy.
Subject(s)
Scalp Dermatoses/diagnosis , Acne Keloid/diagnosis , Adolescent , Adult , Alopecia Areata/diagnosis , Cellulitis/diagnosis , Child , Child, Preschool , Dermatitis Herpetiformis/diagnosis , Dermatitis, Contact/diagnosis , Dermatitis, Seborrheic/diagnosis , Folliculitis/diagnosis , Herpes Zoster/diagnosis , Herpes Zoster/pathology , Humans , Lice Infestations/diagnosis , Lichen Planus/diagnosis , Lupus Erythematosus, Discoid/diagnosis , Neurodermatitis/diagnosis , Pemphigus/diagnosis , Psoriasis/diagnosis , Pyoderma/diagnosis , Scleroderma, Localized/diagnosis , Tinea Capitis/diagnosisSubject(s)
Education, Medical , Skin Diseases/diagnosis , Adolescent , Humans , Male , Skin Diseases/etiologySubject(s)
Acrodermatitis/diagnosis , Acrodermatitis/therapy , Child , Humans , Male , Skin/pathologyABSTRACT
Swimmer's itch and seabather's eruption, while similar in morphology, differ in important aspects. Seabather's eruption occurs chiefly in salt water and involves covered parts of the body. Swimmer's itch occurs chiefly in fresh water and involves uncovered parts. The cause of swimmer's itch is definitely known to be schistosome cercariae, while the cause of seabather's eruption is for the most part unknown. Algae, coelenterates and schistosomes as well as other organisms found in seawater have been suggested. Control of swimmer's itch is best accomplished by decreasing the snail population.
