[Interleukin-1 production in patients with subacute and chronic opisthorchiasis]. / Produktsiia interleikina-1 u bol'nykh podostrym i khronicheskim opistorkhozom.

Interleukin-1 (IL-1) production by peripheral blood lymphocytes was studied in 3 patients with the subacute and in 28 patients with the chronic stage of the disease. Monocyte culture was obtained by the H. R. Recalde method, IL-1 activity was evaluated by the S. B. Mizel modification of the classic LAF-ASSAY. In the subacute stage of the disease IL-1 activity was 3.3 fold lower that in healthy controls and lower than in the total group of patients with chronic opisthorchiasis (Kact. 0.64 +/- 0.09, 2.12 +/- 0.17, 1.83 +/- 0.11, respectively, p < 0.01, p < 0.01). In those with the syndrome of chronic gastroduodenitis IL-1 production was lower than in patients with the syndrome of cholepathy (Kact. 1.55 +/- 0.18 and 2.03 +/- 0.16, p < 0.01). Immediately after praziquantel therapy IL-1 production fell from Kact. 1.82 +/- 0.13 to 1.18 +/- 0.06 (p < 0.01), but 5-6 months later the production of the cytokine normalized in convalescents.

[Characteristics of the production of lymphokines regulating the function of the cells of the phagocytic system on exposure to cyclosporin A]. / Osobennosti otsenki produktsii limfokinov, reguliruiushchikh funktsii kletok fagotsitarnoi sistemy pri vozdeistvii tsiklosporina A.

Gel chromatographic studies and the detection of the biological activity have demonstrated that cyclosporin A decreases the level of protein secretion and stimulates the therapeutic effect of lymphokines on wound healing.

[Activation of monocytes during hemodialysis]. / Aktivatsiia monotsitov vo vremia gemodializa.

The authors conducted a clinical study of the hypothesis of interleukin-1 regarded as one of the most important topics in the problem of biocompatibility of dialytic membranes. Hemodialyses (HD) were performed using different cellulose and synthetic membranes. During HD research was made into the kinetics of monocytes and lymphocytes, monocytic activation expressed by a stimulation index, and the deposition of blood elements on the membranes of parallel membrane dialysers. All types of cellulose membranes were characterized by acute dialytic monocytopenia. Synthetic membranes produced no considerable monocytopenia. No convincing data on the dependence of the monocytic stimulation effect on membrane material were obtained. Possible mechanisms of monocytic activation during HD were discussed.