Design principles of biologically fabricated avian nests.

Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest swiftlet Aerodramus fuciphagus on vertical rock walls using threaded saliva. Utilizing its own saliva as a construction material allows the swiftlets full control over the structural features at a very high resolution in a process similar to additive manufacturing. It was hypothesized that the mechanical properties would vary between the structural regions of the nest (i.e. anchoring to the wall, center of the cup, and rim) mainly by means of architecture to offer structural support and bear the natural loads of birds and eggs. We generated numerical models of swiftlet nests from µCT scans based on collected swiftlet nests, which we loaded with a force of birds and eggs. This was done in order to study and assess the stress distribution that characterizes the specific nest's architecture, evaluate its strength and weak points if any, as well as to understand the rationale and benefits that underlie this natural structure. We show that macro- and micro-scale structural patterns are identical in all nests, suggesting that their construction is governed by specific design principles. The nests' response to applied loads of birds and eggs in finite element simulations suggests a mechanical overdesign strategy, which ensures the stresses experienced by its components in any loading scenario are actively minimized to be significantly smaller than the tensile fracture strength of the nests' material. These findings highlight mechanical overdesign as a biological strategy for resilient, single-material constructions designed to protect eggs and hatchlings.

Sensitivity of Arterial Hyperelastic Models to Uncertainties in Stress-Free Measurements.

Despite major advances made in modeling vascular tissue biomechanics, the predictive power of constitutive models is still limited by uncertainty of the input data. Specifically, key measurements, like the geometry of the stress-free (SF) state, involve a definite, sometimes non-negligible, degree of uncertainty. Here, we introduce a new approach for sensitivity analysis of vascular hyperelastic constitutive models to uncertainty in SF measurements. We have considered two vascular hyperelastic models: the phenomenological Fung model and the structure-motivated Holzapfel-Gasser-Ogden (HGO) model. Our results indicate up to 160% errors in the identified constitutive parameters for a 5% measurement uncertainty in the SF data. Relative margins of errors of up to 30% in the luminal pressure, 36% in the axial force, and over 200% in the stress predictions were recorded for 10% uncertainties. These findings are relevant to the large body of studies involving experimentally based modeling and analysis of vascular tissues. The impact of uncertainties on calibrated constitutive parameters is significant in context of studies that use constitutive parameters to draw conclusions about the underlying microstructure of vascular tissues, their growth and remodeling processes, and aging and disease states. The propagation of uncertainties into the predictions of biophysical parameters, e.g., force, luminal pressure, and wall stresses, is of practical importance in the design and execution of clinical devices and interventions. Furthermore, insights provided by the present findings may lead to more robust parameters identification techniques, and serve as selection criteria in the trade-off between model complexity and sensitivity.

Controlled tunneling of cold atoms: from full suppression to strong enhancement.

Two recent experiments have demonstrated the phenomenon of dynamical tunneling of cold atoms interacting with standing electromagnetic waves. We show by quantitative calculations that one can achieve a control of the tunneling period over an orders of magnitude range by changing the frequency difference of the waves by about 10% only. In this narrow parameter region, the mechanism of the tunneling oscillations evolves from the two-state to the three-state one. Our calculations demonstrate that the change in the underlying mechanism leads to the dramatic enhancement of the dynamical tunneling. Moreover, a complete suppression of the dynamical tunneling can also be achieved in the cold atom setup.