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Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19.
Tran, Florian; Harris, Danielle M M; Scharmacher, Alena; Graßhoff, Hanna; Sterner, Kristina; Schinke, Susanne; Käding, Nadja; Humrich, Jens Y; Cabral-Marques, Otávio; Bernardes, Joana P; Mishra, Neha; Bahmer, Thomas; Franzenburg, Jeanette; Hoyer, Bimba F; Glück, Andreas; Guggeis, Martina; Ossysek, Alexander; Küller, Andre; Frank, Derk; Lange, Christoph; Rupp, Jan; Heyckendorf, Jan; Gaede, Karoline I; Amital, Howard; Rosenstiel, Philip; Shoenfeld, Yehuda; Halpert, Gilad; Rosenberg, Avi Z; Schulze-Forster, Kai; Heidecke, Harald; Riemekasten, Gabriela; Schreiber, Stefan.
ERJ Open Res ; 8(4)2022 Oct.
Article in English | MEDLINE | ID: mdl-36575710

ABSTRACT

In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv.

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