A 12.5 GHz-spaced optical frequency comb spanning >400 nm for near-infrared astronomical spectrograph calibration.

A 12.5 GHz-spaced optical frequency comb locked to a global positioning system disciplined oscillator for near-infrared (IR) spectrograph calibration is presented. The comb is generated via filtering a 250 MHz-spaced comb. Subsequent nonlinear broadening of the 12.5 GHz comb extends the wavelength range to cover 1380-1820 nm, providing complete coverage over the H-band transmission window of earth's atmosphere. Finite suppression of spurious sidemodes, optical linewidth, and instability of the comb has been examined to estimate potential wavelength biases in spectrograph calibration. Sidemode suppression varies between 20 and 45 dB, and the optical linewidth is approximately 350 kHz at 1550 nm. The comb frequency uncertainty is bounded by +/-30 kHz (corresponding to a radial velocity of +/-5 cm/s), limited by the global positioning system disciplined oscillator reference. These results indicate that this comb can readily support radial velocity measurements below 1 m/s in the near IR.

Concentration of rocuronium in cerebrospinal fluid of patients undergoing cerebral aneurysm clipping.

BACKGROUND: This study assessed the concentration of rocuronium in the cerebrospinal fluid (CSF) of patients undergoing cerebral aneurysm clipping, and investigated whether the mode of administration (single bolus vs continuous infusion) influenced the CSF concentration. METHODS: Twenty patients with subarachnoid haemorrhage were randomly allocated to receive a bolus dose (bolus group), or a bolus followed by a continuous infusion of rocuronium (infusion group) (n=10 for each group). Arterial blood and ventricular CSF were sampled 2 h after the rocuronium bolus. Samples were analysed by liquid chromatography electrospray ionization-tandem mass spectrometry. RESULTS: Rocuronium could be detected in all the CSF samples. The mean (range) CSF concentration was 2.2 (0.9-4.6) ng x ml(-1) in the bolus group and 12.4 (2.4-34.6) ng x ml(-1) in the infusion group; P<0.01. CONCLUSIONS: This study demonstrated that rocuronium, normally not considered to cross the blood-brain barrier, is regularly found in the CSF of patients undergoing cerebral clipping; continuous infusion of the drug led to higher plasma and CSF concentrations than after a single bolus dose.

Effects of milking frequency on lying down and getting up behaviour in dairy cows.

The objective of this study was to investigate if cows milked twice per day have more difficulty lying down and getting up and spend less time lying than cows milked three times per day. Seventeen cows of the Swedish Red and White Cattle Breed were studied, seven of which were milked twice daily (2M) and ten were milked three times (3M) daily. They were kept in individual cubicles, that were closed in the rear end with a rope. They had free access to a mixture of silage, hay and concentrate. The individual cows were video-recorded for 24h every fourth week, starting four weeks after calving for four times. The 2M cows stood significantly longer, 128.11min, than the 3M cows, 64.88min, (P<0.01) during the 4h before morning milking. The 2M cows also had a tendency for longer duration of standing rumination (P=0.059) as well as significantly more bouts of standing rumination (P<0.01) during these hours than the 3M cows. The cows in the 3M group spent less time on the getting up movement (P<0.05) during the 4h before morning milking. The distribution of the lying bouts during these 4h differed significantly between the groups, where the 3M cows had fewer lying bouts shorter than 15min and more lying bouts longer than 90min. The results indicate that milking three times a day contributes to increased comfort in high-producing dairy cows.

Laboratory detection of X-ray fringes with a grazing-incidence interferometer

Starting with Galileo's observations of the Solar System, improvements of an order of magnitude in either the sensitivity or resolution of astronomical instruments have always brought revolutionary discoveries. The X-ray band of the spectrum, where exotic objects can have extremely high surface brightness, is ideally suited for significant improvements in imaging, but progress has been impeded by a lack of optics of sufficiently high sensitivity and quality. Here we present an X-ray interferometer design that is practical for adaptation to astronomical observatories. Our prototype interferometer, having just under one millimetre of baseline, creates fringes at 1.25 keV with an angular resolution of 100 milliarcseconds. With a larger version in orbit it will be possible to resolve X-ray sources at 10(-7) arcseconds, three orders of magnitude better than the finest-resolution images ever achieved on the sky (in the radio part of the spectrum) and over one million times better than the current best X-ray images. With such resolutions, we can study the environments of pulsars, resolve and then model relativistic blast waves, image material falling into a black hole, watch the physical formation of astrophysical jets, and study the dynamos of stellar coronae.

Comparison of the imaging characteristics of curved-channel and straight-channel microchannel plates.

We have measured and compared the spatial fidelity of two types of microchannel plates over roughly half of their active area. Measurements of the spatial fidelity of curved-channel microchannel plates confirm earlier reports of large (>25 microm), irregular position offsets between the front and the back of the microchannel plates. Straight-pore microchannel plates used in a chevron configuration, on the other hand, showed almost no such position offsets (<4 microm).

A review of mandibular anesthesia nerve block techniques.

Anesthesia of the mandibular division of the trigeminal nerve is a routine dental procedure. However, failure to achieve a satisfactory level of anesthesia occurs often and can be frustrating for patient and practitioner alike. In this review article, the three most familiar mandibular nerve block techniques-the conventional Halsted approach and the Gow-Gates and Akinosi techniques-are presented and the advantages and disadvantages of each discussed.

Photometric calibration of the first three spectroscopic orders of an extreme-ultraviolet spectrometer by use of synchrotron radiation.

We report here a technique for determining the quantum throughput of a high-resolution, extreme-UV spectrometer by use of the National Institute of Standards and Technology's Synchroton Ultraviolet Radiation Facility at Gaithersburg, Md. (SURF-II). Observations were obtained at three different synchrotron operating energies with and without a magnesium fluoride filter and a tin-germanium filter. This calibration permits us to extract system efficiencies for three overlapping spectroscopic orders with uncertainties of 10-30%. The uncertainties quoted in this preliminary experiment were limited by the available time, and we propose that with minor refinements a significant improvement could be realized.