ABSTRACT
Whole body X-irradiation of pregnant NMRI-mice between day 11--13 after conception results in pathological morphogenesis of the CNS. These effects are reduction of dimensions of forebrain, desorganisation of structure and occurrence of spherical cell arrangements, the so called rosettes. These can be especially found in dorsal parts of the hemispheres and have been registered qualitatively by its number and dimension in the dose range between 3 X 110 R and 3 X 120 R. A clear correlation between the number of rosettes and the reduction of thickness of the hemisphere-walls can be demonstrated. These results will be fundamental for further studies concerning with reparation processes of the irradiation damage in postnatal stages.
Subject(s)
Brain/abnormalities , Radiation Injuries, Experimental/pathology , Animals , Brain/pathology , Brain/radiation effects , Female , Mice , Pregnancy , Radiation Dosage , Time FactorsABSTRACT
For the visual evaluation of the EEG in children (awake) 17 items are formulated and defined. They are to be examined and determined as beeing either optimal or non-optimal, as it is easier to define what is optimal, than what is normal. The non-optimal items are summed up for a total score. It could be shown that this score discriminates between sample groups of 50 children each, one with "minimal brain dysfunction" and another with normal controls of the same age and sex. There are also several distinct differences within the particular items. The objectivity of the items was proved by fourfold examination of the same sample group. The concept of optimality therefore offers a valid and objective method of quantifying the visual EEG evaluation, thus improving the interpretation of minor abnormalities in the EEG.
