[Multifaceted analysis of the interactions of morphophysiologic signs and ischemic ECG changes (a population study)]. / Mnogomernyi analiz vzaimosviazei morfofiziologicheskikh priznakov i ishemicheskikh izmenenii EKG (populiatsionnoe issledovanie).

Relationships between serum lipid and lipoprotein levels, arterial blood pressure, body weight and age, on the one hand, and coronary heart disease (CHD), on the other, were investigated by means of the main constituents analysis in a Northern Khant population. The pattern of relationship between the parameters in question was similar, by the first main constituent, in males and females, and suggested their age-dependence, unrelated to CHD. The second constituent, as a sum total of the effects of another factor, showed an unbalance between body weight and blood lipids, which was correlated with CHD in males and remained indifferent with respect to CHD in females.

[The prevalence of ECG ischemic changes and their relation to basic risk factors among the Khanty of the Ob River region]. / Rasprostranennost' ishemicheskikh izmenenii EKG i ikh sviaz' s osnovnymi faktorami riska u obskikh khantov.

The incidence of coronary heart disease (CHD) was determined, on the basis of extended Minnesota code criteria, in a Siberian population of northern Khanty of both sexes, aged 19 to 69 years (a total of 721 people). CHD prevalence by age was 34 +/- 3% in males and 24 +/- 2% in females. CHD prevalence in males below 40 showed no significant relation with any of the major risk factors, while a positive correlation with hypercholesterolemia and hypo-alpha-cholesterolemia was noted in people of older age. Females of different age showed a negative correlation with arterial hypertension, and a positive correlation with hypercholesterolemia and hypertriglyceridemia. Excessive body weight is not a CHD risk factor for the Khanty.

[A complex medico-genetic study of West Siberian populations. I. Formulation of a problem. Goals and objectives of the study. Population genetic characteristics of Northern Khanty]. / Kompleksnoe mediko-geneticheskoe izuchenie naseleniia Zapadnoi Sibiri. Soobshchenie I. Postanovka problemy. Tseli i zadachi issledovaniia. Populiatsionno-geneticheskaia kharakteristika severnykh khantov.

Purposes and tasks of the complex medical and genetic study of West-Siberian inhabitants were formulated. Demographic parameters for the North Khanty inhabitants, such as size, dynamics of the tertiary sex ratio, marriage structure and migration processes were presented. Mating and intrapopulation migration patterns are determined by spatial subdivision, because of the vast territory and the traditional way of life, and by isolation by distance. Index of the isolocal endogamy equals to 0.364. The portion of mixed marriages is 22.7% and that of the gametic contribution of immigrants - 7.3%. Inbreeding coefficient by isonymy is 0.00097. Effective population size of the five subpopulations studied as a whole is 25% of their total number.

[Medical genetic research on the Khanty population of the Ovgort rural district of the Yamal-Nenets Autonomous territory]. / Mediko-geneticheskoe issledovanie khantyiskogo naseleniia sel'skogo Soveta Ovgort Iamalo-Nenetskogo avtonomnogo okruga.

The results of medico-genetical studies of the Khanty from the Lower Ob river carried out by Tomsk Department of Institute of Medical Genetics of Academy of Medical Sciences of the USSR are presented. The population is characterized by a relatively high index of endogamy (0.54) and a low inbreeding coefficient (0.0011). Diseases of the polygenic mode of inheritance predominate among nosological forms of hereditary pathology.