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Polim Med ; 7(4): 245-53, 1977.
Article in Russian | MEDLINE | ID: mdl-614539

ABSTRACT

The biologic side effects were studied of a polymer of isonicotinic acid hydrazide (PINH) synthesized on the basis of the copolymer vinylpyrrolidone and crotonaldehyde. The influence of dosage and conditions of administration as a functional and morphologic indicator in animals were also investigated. Threshold dosage and optimal conditions of administration in clinical practice are recommended.


Subject(s)
Isoniazid/toxicity , Animals , Drug Evaluation, Preclinical , Guinea Pigs , Isoniazid/administration & dosage , Isoniazid/chemical synthesis , Mice , Rats
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