1.
J Antibiot (Tokyo)
; 42(11): 1535-40, 1989 Nov.
Article
in English
| MEDLINE
| ID: mdl-2584134
ABSTRACT
Two antifungal antibiotics maniwamycins A and B were isolated from the culture broth of a strain of actinomycetes, which were classified as Streptomyces prasinopilosus. These antibiotics were isolated by resin absorption and extraction with EtOAc and purified by column chromatography. Both antibiotics were found to be new azoxy substances from their physico-chemical properties. They showed broad antifungal spectra.
Subject(s)
Antifungal Agents/isolation & purification , Streptomyces/classification , Animals , Antifungal Agents/analysis , Antifungal Agents/toxicity , Azo Compounds/isolation & purification , Azo Compounds/pharmacology , Azo Compounds/toxicity , Chemical Phenomena , Chemistry, Physical , Fermentation , Hydrogen-Ion Concentration , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Rats , Spectrophotometry, Infrared , Spectrophotometry, Ultraviolet , Streptomyces/metabolism
2.
J Antibiot (Tokyo)
; 42(11): 1541-6, 1989 Nov.
Article
in English
| MEDLINE
| ID: mdl-2584135
ABSTRACT
The structures of the new azoxy antibiotics maniwamycins A and B have been determined by means of spectral analyses and chemical studies.
Subject(s)
Antifungal Agents , Antifungal Agents/analysis , Azo Compounds , Hydrogen , Magnetic Resonance Spectroscopy , Mass Spectrometry , Molecular Structure , Oxidation-Reduction , Spectrophotometry, Infrared , Spectrophotometry, Ultraviolet
3.
Horumon To Rinsho
; 31 Suppl: 90-2, 1983 Jun.
Article
in Japanese
| MEDLINE
| ID: mdl-6616931
4.
Yakugaku Zasshi
; 98(7): 937-43, 1978 Jul.
Article
in Japanese
| MEDLINE
| ID: mdl-712558
Subject(s)
Prazepam/metabolism , Animals , Carboxylic Acids/toxicity , Cyclopropanes/toxicity , Female , Lethal Dose 50 , Male , Prazepam/urine , Rats , Tissue Distribution
5.
Biochem Pharmacol
; 25(11): 1293-7, 1976 Jun 01.
Article
in English
| MEDLINE
| ID: mdl-820350
