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Hiroshima J Med Sci ; 52(1): 9-13, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12701648

ABSTRACT

The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 10% long-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.


Subject(s)
Adenocarcinoma/prevention & control , Fermentation , Glycine max , Lung Neoplasms/prevention & control , Animals , Diet , Male , Nitrosamines , Organ Size , Rats , Rats, Wistar
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