ABSTRACT
Background: Early detection of breast cancer (BC) is important to reduce mortality rates. To prevent BC, women should adopt self-care behaviors. This study aimed at examining risk and illness perception and self-care of healthy women regarding breast cancer. Methods: Participants were 211 women (M=59.11 years, SD=8.54) and with no personal history of the illness, selected by convenience. Measures were a sociodemographic, clinical and health behavior questionnaire, illness perception and risk perception questionnaires. Nonparametric statistics (Spearman) was employed to analyze the relationship between illness perception, risk perception and sociodemographic variables. The open answers to the causes of the illness were classified according to the content analysis. Results: We found a relationship between risk and illness perception and self-care in healthy women regarding BC. It was identified that women had reasonable illness coherence (M=3.18) and considered the illness more timeline chronic than timeline acute (M=3.22), reasonable timeline cyclical (M=3.56), with severe consequences for health (M=4.22), and reasonably threatening (M=3.15). Conclusions: BC and risk perception and self-care are interrelated variables among healthy women.
Introdução: A detecção precoce do câncer de mama (CM) é importante para reduzir as taxas de mortalidade. Para preveni-lo, a mulher deve adotar comportamentos de autocuidado em saúde. Esse estudo objetiva examinar a percepção de risco, a percepção da doença e o autocuidado de mulheres saudáveis com relação ao CM. Método: Participaram 211 mulheres (M=59,11 anos; DP=8,54) sem histórico de CM selecionados por conveniência. Os instrumentos foram questionário de dados sociodemográficos, clínicos e de comportamento em saúde, questionários de percepção da doença e percepção de risco. Estatística não paramétrica (Spearman) foi utilizada para analisar a relação entre percepção da doença, percepção de risco e variáveis sociodemográficas. As respostas abertas sobre as causas da doença foram classificadas segundo análise de conteúdo. Resultados: Observou-se que existe relação entre a percepção de risco e da doença, e autocuidado em mulheres saudáveis. Identificou-se que as mulheres têm razoável percepção de entendimento da doença (M=3.18), a consideravam mais crônica que aguda (M=3.22), razoavelmente cíclica (M=3,56), com consequências graves à saúde (M=4,22), e relativamente ameaçadora (M=3,15). Conclusões: A percepção do CM, a percepção de risco e o autocuidado são variáveis inter-relacionadas em mulheres saudáveis.
Introducción: La detección precoz del câncer de mama (CM) es importante para reducir los índices de mortalidade. Para prevenirlo, la mujer debe adoptar conductas de autocuidado en salud. El objetivo es examinar la percepción de riesgo, la percepción de la enfermedad y el autocuidado de mujeres sanas con relación al CM. Método: Participaron 211 mujeres (M=59,11 años; DP=8,54), sin histórico de CM seleccionadas por conveniencia. Los instrumentos fueron cuestionário de datos sociodeográficos, clínicos y de conductas em salud, cuestionários de percepción de la enfermedad y percepción de riesgo. Estadística no paramétrica (Spearman) ha sido utilizada para examinar la relación entre percepción de la enfermedad, de riesgo y variables sociodemográficas. Las preguntas abiertas sobre las causas de la enfermedad fueron clasificadas a través de análisis de contenido. Resultados: Se observó que existe relación entre percepción de riesgo y de la enfermedady el autocuidado em mujeres sanas. Se identifico que las mujeres tienen razonable percepción de comprehensión de la enfermedad (M=3,18), la consideran más crónica que aguda (M=3,22), razonablemente cíclioca (M=3,36), con consecuencias graves a la salud (M=4,22) y relativamente amenazadora (M=3,15). Conclusiones: la percepción del CM, la percepción de riesgo y el autocuidado son variables inter-relacionadas em mujeres sanas.
Subject(s)
Psychology , Self Care , Breast NeoplasmsABSTRACT
Pneumococcal meningitis is associated with the highest fatality case ratios in the world. Most of patients that survive present neurologic sequelae at later times as well as biochemicals alterations such as oxidative stress in both earlier and later times after central nervous system infection. In this context, we evaluated the effect of antioxidant treatment on memory and oxidative parameters in the hippocampus of meningitis survivor rats 10 days after infection. To this aim, the animals underwent a magna cistern tap receiving either 10 µL sterile saline as a placebo or an equivalent volume of a Streptococcus pneumoniae suspension at the concentration 5x10(9) cfu/mL. The animals submitted to meningitis were divided into the following groups: 1) treated with antibiotic, 2) treated with basic support plus N-acetylcysteine, 3) treated with basic support plus deferoxamine, 4) treated with basic support plus N-acetylcysteine and deferoxamine, or 5) treated with N-acetylcysteine plus deferoxamine. Ten days after meningitis, the animals underwent inhibitory avoidance and habituation to an open field tasks and, immediately after, were assessed for oxidative damage in the hippocampus and cortex. The meningitis group showed significantly decreased performance in latency retention compared with the sham group in the inhibitory avoidance task. In the open-field task, the meningitis group presented memory impairment after meningitis. All these memory impairments were prevented by N-acetylcysteine plus deferoxamine with or without basic support and its isolate use. In addition, there was an increase of lipid phosphorylation in cortex and hippocampus and all the combined antioxidants attenuated lipid phosphorylation in both structures. On the other hand, there was an increase of protein phosphorylation in cortex and N-acetylcysteine plus deferoxamine with or without basic support prevented it. Thus, we hypothesize that oxidative stress may be related to cognitive impairment in pneumococcal meningitis.
