ABSTRACT
BACKGROUND: The aim is to determine whether good functional and quality of life results of sacral nerve stimulation (SNS) in patients with severe fecal incontinence are maintained in the long-term. MATERIAL AND METHODS: Consecutive cohort of patients with severe fecal incontinence not responding to conservative (drugs and/or biofeedback) or surgical (sphincteroplasty) treatment, undergoing SNS between 2002 and 2013. Patients with a definitive implant were individually assessed in consultation throughout the follow-up, until January 2016. Defeca-tory function was assessed by Wexner score and stool diary, and perceived quality of life by FIQL and EQ-5D question-naires. RESULTS: Acute percutaneous nerve evaluation (PNE) was performed on 93 patients; a temporary electrode was implanted in 91 (79.1% women, mean age 62.5 years), obtaining a good functional response in 64. A permanent implant was per-formed in 61 patients, with a mean follow-up of 78.1 months (SD: 35.4; range 1-161); at the end of the study 42 patients remained in follow-up. A significant decrease was observed in the number of days per week with an incontinent episode, from 4.98 (SD 2.1) to 1.25 (SD 1.7), and in Wexner score from 16.88 (SD 2.74) to 6.95 (SD 3.54). Specific FIQL and generic EQ-5D questionnaires showed a significant improvement in quality of life. CONCLUSION: Long-term functional and quality of life outcomes of SNS for the treatment of severe faecal incontinence is maintained, with individual follow-ups that reach 10 years.
Subject(s)
Electric Stimulation Therapy , Fecal Incontinence , Fecal Incontinence/therapy , Female , Follow-Up Studies , Humans , Male , Middle Aged , Quality of Life , Treatment OutcomeABSTRACT
FUNDAMENTO: El objetivo fue conocer si la mejora funcional y de calidad de vida lograda con la neuroestimulación de raíces sacras (SNS) en pacientes con incontinencia fecal grave se mantiene a largo plazo. MATERIAL Y MÉTODOS: Cohorte consecutiva de pacientes con incontinencia fecal grave que no respondieron a manejo conservador (fármacos y/o biofeedback) o quirúrgico (esfinteroplastia); se realizó SNS entre 2002 y 2013. A los pacientes con implante definitivo se les valoró individualmente en consulta a lo largo del seguimiento, hasta enero de 2016. Se valoró la función defecatoria mediante el score Wexner y el diario defecatorio, y la calidad de vida percibida con los cuestionarios FIQL y EQ-5D. RESULTADOS: Se realizó la estimulación aguda a 93 pacientes, y se implantó el electrodo temporal a 91 (79,1% mujeres, edad media 62,5 años) con buen resultado funcional en 64. El generador definitivo se implantó en 61 pacientes seguidos una media de 78,1 meses (DE: 35,4; rango 1-161); al finalizar el estudio, 42 pacientes seguían en seguimiento. Se observó una disminución significativa del número de días con escapes/semana de 4,98 (DE: 2,1) a 1,25 (DE: 1,7) y de las puntuaciones del score Wexner de 16,88 (DE: 2,74) a 6,95 (DE: 3,54). La calidad de vida percibida mejoró de forma significativa, al observarse un aumento de las puntuaciones de los cuestionarios FIQL y EQ-5D. CONCLUSIONES: La SNS mantiene buenos resultados funcionales y de calidad de vida en pacientes con incontinencia fecal grave a largo plazo, con seguimientos individuales que alcanzan los 10 años
BACKGROUND: The aim is to determine whether good functional and quality of life results of sacral nerve stimulation (SNS) in patients with severe fecal incontinence are maintained in the long-term. MATERIAL AND METHODS: Consecutive cohort of patients with severe fecal incontinence not responding to conservative (drugs and/or biofeedback) or surgical (sphincteroplasty) treatment, undergoing SNS between 2002 and 2013. Patients with a definitive implant were individually assessed in consultation throughout the follow-up, until January 2016. Defecatory function was assessed by Wexner score and stool diary, and perceived quality of life by FIQL and EQ-5D questionnaires. RESULTS: Acute percutaneous nerve evaluation (PNE) was performed on 93 patients; a temporary electrode was implanted in 91 (79.1% women, mean age 62.5 years), obtaining a good functional response in 64. A permanent implant was performed in 61 patients, with a mean follow-up of 78.1 months (SD: 35.4; range 1-161); at the end of the study 42 patients remained in follow-up. A significant decrease was observed in the number of days per week with an incontinent episode, from 4.98 (SD 2.1) to 1.25 (SD 1.7), and in Wexner score from 16.88 (SD 2.74) to 6.95 (SD 3.54). Specific FIQL and generic EQ-5D questionnaires showed a significant improvement in quality of life. CONCLUSION: Long-term functional and quality of life outcomes of SNS for the treatment of severe faecal incontinence is maintained, with individual follow-ups that reach 10 years
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Transcutaneous Electric Nerve Stimulation , Fecal Incontinence/therapy , Severity of Illness Index , Treatment Outcome , Follow-Up Studies , Longitudinal Studies , Sacrococcygeal Region , Cohort StudiesABSTRACT
El carcinoma colorrectal es un tumor que con muy poca frecuencia origina metástasis cutáneas, y cuando lo hace raramente es por vía hematógena. Presentamos el caso de un varón de 55 años diagnosticado de un adenocarcinoma de recto (tercio inferior) estadioT3N2M0. Tratado inicialmente con radioquimioterapia neoadyuvante, fue intervenido ocho semanas después realizándose una amputación abdominoperineal extendida. El resultado anatomopatológico fue de adenocarcinoma mucinoso de recto, estadio ypT3bN1. Tras un postoperatorio sin complicaciones el paciente recibió tratamiento quimioterápico con capecitabina. A los 18 meses el paciente refirió la aparición progresiva de nódulos subcutáneos en distintas localizaciones. En la tomografía computarizada de control se objetivaron múltiples imágenes sugestivas de metástasis a nivel hepático y pulmonar, así como lesiones subcutáneas. La exéresis-biopsia de uno de los nódulos subcutáneos corroboró la sospecha de metástasis de adenocarcinoma de recto. Se valoró tratamiento quimioterápico que no llegó a administrarse por el rápido deterioro del paciente que llevó al exitus (AU)
Colorectal carcinoma is a tumour that very infrequently gives rise to cutaneous metastases and when it does so, it is rarely by the haematogenous route. We present the case of a 55-year old male diagnosed with anadenocarcinoma of the rectum (lower third), clinical stageT3N2M0. Initially treated with neoadjuvant radiochemotherapy, he was operated on eight weeks later, with an extended abdominoperineal amputation. The anatomopathological result was mucinous adenocarcinoma of the rectum, clinical stage ypT3bN1. Following a postoperative period without complications, the patient received chemotherapeutic treatment with capecitabine. Eighteen months later the patient reported the progressive appearance of subcutaneous nodules in different localizations. In the computerized tomography test multiple images were objectivized suggesting metastasis at the hepatic and pulmonary levels, as well as subcutaneous lesions. The biopsy-excision of one of the subcutaneous nodules corroborated the suspicion of metastasis of the adenocarcinoma of the rectum. Chemotherapy treatment was considered for the patient, which was not administered due to the rapid deterioration of the patient leading to his death (AU)
Subject(s)
Humans , Male , Middle Aged , Rectal Neoplasms/pathology , Skin Neoplasms/secondary , Neoplasm Metastasis/pathology , Biopsy , Endoscopy, GastrointestinalABSTRACT
Colorectal carcinoma is a tumour that very infrequently gives rise to cutaneous metastases and when it does so, it is rarely via the haematogenous route. We present the case of a 55-year old male diagnosed with an adenocarcinoma of the rectum (lower third), clinical stage T3N2M0. Initially treated with neoadjuvant radiochemotherapy, he was operated on eight weeks later, with an extended abdominoperineal amputation. The anatomopathological result was mucinous adenocarcinoma of the rectum, clinical stage ypT3bN1. Following a postoperative period without complications, the patient received chemotherapeutic treatment with capecitabine. Eighteen months later the patient reported the progressive appearance of subcutaneous nodules in different localizations. In the computerized tomography test multiple images were objectivized suggesting metastasis at the hepatic and pulmonary levels, as well as subcutaneous lesions. The biopsy-excision of one of the subcutaneous nodules corroborated the suspicion of metastasis of the adenocarcinoma of the rectum. Chemotherapy treatment was considered for the patient, which was not administered due to the rapid deterioration of the patient leading to his death.
Subject(s)
Adenocarcinoma, Mucinous/secondary , Rectal Neoplasms/pathology , Skin Neoplasms/secondary , Humans , Male , Middle AgedABSTRACT
BACKGROUND: The aim was to assess quality of life in a group of patients who had a curative resection for gastric cancer. METHODS: The European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire with a gastric cancer-specific module was used in patients who had undergone R0 gastrectomy between 1992 and 1999, and who had no disease at the last check-up. A response was obtained from 54 patients, 36 men and 18 women, of mean age 67 years. Of these, 24 patients had total gastrectomy and 26 D2 lymphadenectomy. RESULTS: Significant differences were found only in the social domain of quality of life in patients aged over 70 years (P = 0.036); there was no impact of operation type on overall quality of life. CONCLUSION: The quality of life of patients undergoing curative surgery for gastric cancer, regardless of age, was not significantly influenced by the type of gastrectomy, or whether lymphadenectomy was performed.
Subject(s)
Quality of Life , Stomach Neoplasms/surgery , Adult , Age Factors , Aged , Aged, 80 and over , Female , Follow-Up Studies , Gastrectomy/methods , Humans , Lymph Node Excision/methods , Male , Middle Aged , Sex FactorsABSTRACT
Cystic neoplasms of the pancreas make up a group of uncommon tumors. Their relevance lies upon their favorable prognosis after resection and the fact of being commonly mistaken with pseudocysts. Based on five patients treated at our hospital in the last few years we make an update review of the literature on these tumors. To note the role that imaging and puncture-aspiration techniques can play for diagnosis. We conclude that when a cystic lesion of the pancreas is found, the diagnosis of cystic neoplasm must be considered, thus avoiding delays in surgical resections which may condition the patient's prognosis.
