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1.
(-)-5alpha-Hydroxysophocarpine, a New Lupin Alkaloid from the Seeds of Sophora flavescens var. angustifolia1.
Saito, K; Arai, N; Sekine, T; Ohmiya, S; Kubo, H; Otomasu, H; Murakoshi, I.
Planta Med ; 56(5): 487-8, 1990 Oct.
Article in English | MEDLINE | ID: mdl-17221455
2.
Aziridines in Alkaloid Synthesis. IV. A Formal Synthesis of alpha-Dihydrocaranone and gamma-Lycorane.
Higashiyama, H; Honda, T; Otomasu, H; Kametani, T.
Planta Med ; 48(8): 268-71, 1983 Aug.
Article in English | MEDLINE | ID: mdl-17404994

ABSTRACT

A facile synthesis of the key intermediates for alpha-dihydrocaranone ( 17) and gamma-lycorane ( 18) has been achieved by employing the ring opening reaction of a N-benzylaziridine derivative ( 10).

3.
[Synthesis by using chirality of l-ephedrine: Asymmetric synthesis of alanine and phenylglycine (author's transl)].
Takahashi, H; Noguchi, H; Tomita, K; Otomasu, H.
Yakugaku Zasshi ; 98(5): 618-22, 1978 May.
Article in Japanese | MEDLINE | ID: mdl-660432

Subject(s)
Alanine/chemical synthesis , Ephedrine , Glycine/analogs & derivatives , Glycine/chemical synthesis , Hydrolysis , Oxidation-Reduction
4.
[Synthesis of 1H-pyrazolo(3,4-b)pyridine and related compounds (author's transl)].
Yoshida, K; Otomasu, H.
Yakugaku Zasshi ; 96(1): 33-6, 1976 Jan.
Article in Japanese | MEDLINE | ID: mdl-943506

Subject(s)
Pyrazoles/chemical synthesis , Pyridines/chemical synthesis
5.
Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols.
Nodiff, E A; Saggiomo, A J; Tanabe, K; Chen, E H; Shinbo, M; Tyagi, M P; Kozuka, A; Otomasu, H; Verma, B L; Goff, D.
J Med Chem ; 18(10): 1011-9, 1975 Oct.
Article in English | MEDLINE | ID: mdl-1099200

ABSTRACT

A series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. A number of these compounds are extremely active against Plasmodium berghei in the mouse. Some structural requirements for optimal efficacy are considered.


Subject(s)
Antimalarials/chemical synthesis , Phenanthrenes/chemical synthesis , Amino Alcohols/chemical synthesis , Amino Alcohols/therapeutic use , Animals , Antimalarials/therapeutic use , Chickens , Halogens/therapeutic use , Malaria/drug therapy , Malaria, Avian/drug therapy , Mice , Phenanthrenes/therapeutic use , Plasmodium berghei , Structure-Activity Relationship
6.
Synthesis of nitrophenylpiperidine N-oxides and their reductive intramolecular ring-closure.
Takahashi, H; Sato, S; Otomasu, H.
Chem Pharm Bull (Tokyo) ; 22(8): 1921-2, 1974 Aug.
Article in English | MEDLINE | ID: mdl-4430041

Subject(s)
Piperidines/chemical synthesis , Cyclic N-Oxides/chemical synthesis , Indicators and Reagents , Methods , Nitrobenzenes/chemical synthesis , Oxidation-Reduction
7.
Antimalarial phenanthrene amino alcohols. 2. Trifluoromethyl-containing 9-phenanthrenemethanols.
Nodiff, E A; Saggiomo, A J; Shinbo, M; Chen, E H; Otomasu, H; Kondo, Y; Kikuchi, T; Verma, B L; Matsuura, S; Tanabe, K; Tyagi, M P; Morosawa, S.
J Med Chem ; 15(7): 775-80, 1972 Jul.
Article in English | MEDLINE | ID: mdl-5043878

Subject(s)
Amino Alcohols/chemical synthesis , Antimalarials/chemical synthesis , Phenanthrenes/chemical synthesis , Amino Alcohols/therapeutic use , Animals , Antimalarials/therapeutic use , Fluorine , Malaria/drug therapy , Methanol/chemical synthesis , Methanol/therapeutic use , Mice , Phenanthrenes/therapeutic use , Structure-Activity Relationship
8.
[Synthesis of condensed quinoxalines. 3. 1,2-dihydroimidazo(1,2-a)quinoxalines and 1,2-dihydro-3H-pyrimido(1,2-a)quinoxalines].
Otomasu, H; Yoshida, K; Takahashi, H.
Yakugaku Zasshi ; 90(11): 1391-5, 1970 Nov.
Article in Japanese | MEDLINE | ID: mdl-5530448

Subject(s)
Quinoxalines/chemical synthesis , Spectrum Analysis
9.
[Synthesis of condensed quinoxalines. I. On the reaction of 11-oxo-11H-indeno[1,2-b]quinoxaline].
Otomasu, H; Omiya, S.
Yakugaku Zasshi ; 89(5): 607-9, 1969 May.
Article in Japanese | MEDLINE | ID: mdl-5817993

Subject(s)
Quinoxalines/chemical synthesis , Chemical Phenomena , Chemistry , Oxidation-Reduction
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