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1.
Pharmazie ; 73(9): 545-552, 2018 09 01.
Article in English | MEDLINE | ID: mdl-30223940

ABSTRACT

The aim of this study was to clarify the clinic-level factors related to experiences of and attitudes toward collaboration with community pharmacies. We conducted a postal questionnaire survey of all clinics in Gifu, Japan, assessing the experiences and attitudes of representative clinical staff regarding the following activities in collaboration with community pharmacists: regional care meetings/service adjustment meetings, case study conferences, joint workshops/continuing education conferences, community services, information sharing through medical cooperation networks, and accompanying community pharmacists during home care. The factors significantly related to experiences of joint workshops/continuing education conferences included home care visits (odds ratio [OR] 2.39) and a 100 % out-of-hospital prescription ratio (OR 4.80). In contrast, only home care visits were significantly associated with consideration of information sharing through medical cooperation networks and accompanying community pharmacists during home care (OR 2.06 and 11.91, respectively). Finally, the factors significantly associated with considering implementing case study conferences and joint workshops/continuing education conferences included home care visits (OR 4.64 and 2.98, respectively) and a 100% out-of-hospital prescription ratio (OR 4.64 and 6.38). Overall, having more opportunities to communicate with community pharmacists and other healthcare professionals appeared to facilitate clinics' consideration of collaboration with community pharmacies, along with actual experiences.


Subject(s)
Community Pharmacy Services/organization & administration , Cooperative Behavior , Health Personnel/statistics & numerical data , Pharmacists/organization & administration , Ambulatory Care Facilities/organization & administration , Ambulatory Care Facilities/statistics & numerical data , Attitude of Health Personnel , Health Personnel/organization & administration , Humans , Interdisciplinary Communication , Interprofessional Relations , Japan , Surveys and Questionnaires
2.
Eur J Gynaecol Oncol ; 35(1): 91-4, 2014.
Article in English | MEDLINE | ID: mdl-24654472

ABSTRACT

The authors report a rare case of peritoneal adenomatoid mesothelioma in a woman with no history of asbestos exposure. A 61-year-old woman was originally suspected of having a bilateral ovarian tumor based on chest radiography and magnetic resonance imaging (MRI). Upon referral to our hospital, the presence of two solid masses was confirmed by enhanced MRI and 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG-PET/CT). Physical examination was normal, as were serum concentrations of the tumor markers CA 19-9, CA 125, and CEA. Laparoscopic surgery showed a right ovarian tumor and laparoscopic right salpingo-oophorectomy and adhesiotomy were performed. Two months later, the patient underwent laparoscopic segmental resection of the sigmoid colon, with histological analysis identifying an adenomatoid-like tumor. The final diagnosis was peritoneal adenomatoid-like mesothelioma with invasion of the right ovary. This case report demonstrates that imaging techniques must be coupled with laparoscopic surgery for an accurate diagnosis of peritoneal mesothelioma.


Subject(s)
Mesothelioma/surgery , Adenomatoid Tumor/diagnosis , Adenomatoid Tumor/pathology , Adenomatoid Tumor/surgery , Diagnosis, Differential , Female , Humans , Laparoscopy , Mesothelioma/diagnosis , Mesothelioma/pathology , Middle Aged , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Peritoneal Neoplasms/diagnosis , Peritoneal Neoplasms/pathology , Peritoneal Neoplasms/surgery
3.
Clin Cancer Res ; 7(7): 2145-51, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11448934

ABSTRACT

We used suppression subtractive hybridization to identify highly expressed genes in the cancerous region of human renal cell carcinoma (RCC) compared with noncancerous tissue. Nine genes were identified to show increased expression in the cancerous region compared with the noncancerous region. The nine genes included thymosin beta4, secreted protein acidic and rich in cysteine (SPARC), Cap43, ceruloplasmin, serum amyloid A, osteopontin, heat shock protein 90 (HSP90), LOT1, and casein kinase I. Of these 9 genes, in situ hybridization with 10 clinical samples consistently showed a strong expression of Cap43 mRNA in infiltrating macrophages in RCCs, but not in cancer cells proliferating in an alveolar pattern. However, Cap43 mRNA was also apparently detected in epithelial cells of the renal proximal tubuli in noncancerous tissue. The higher expression of the Cap43 gene in the cancerous region of RCCs appears to depend on macrophage infiltration. Moreover, treatment with phorbol ester resulted in enhanced expression of the Cap43 gene in human monocytic cells in vitro. The expression of the Cap43 gene in infiltrating macrophages is discussed in association with the differentiated or activated status of monocyte/macrophage.


Subject(s)
Carcinoma, Renal Cell/genetics , Kidney Neoplasms/genetics , Macrophages/metabolism , Proteins/genetics , Adult , Aged , Blotting, Northern , Carcinoma, Renal Cell/pathology , Cell Cycle Proteins , DNA, Complementary/chemistry , DNA, Complementary/genetics , Gene Expression Regulation, Neoplastic , Humans , In Situ Hybridization , Intracellular Signaling Peptides and Proteins , Kidney Neoplasms/pathology , Macrophages/pathology , Male , Monocytes/cytology , Monocytes/drug effects , Monocytes/metabolism , RNA, Messenger/drug effects , RNA, Messenger/genetics , RNA, Messenger/metabolism , RNA, Neoplasm/genetics , RNA, Neoplasm/metabolism , Sequence Analysis, DNA , Tetradecanoylphorbol Acetate/pharmacology
4.
Am Surg ; 67(5): 442-6, 2001 May.
Article in English | MEDLINE | ID: mdl-11379645

ABSTRACT

The results of a hepaticojejunostomy as a biliary-enteric bypass for benign disease are usually excellent. On the other hand, hepatolithiasis features a high rate of residual and recurrent stones with cholangitis after surgery. This study aims to evaluate the long-term results of a hepaticojejunostomy for hepatolithiasis regarding both the degree of the occurrence of postoperative cholangitis and the outcome. The clinical records of 159 patients with hepatolithiasis who underwent surgical treatment over a 23-year period were also retrospectively reviewed. Ninety-four of 159 patients underwent a hepatecetomy and 65 patients were subjected to liver-preserving surgery by means of intra- and postoperative endoscopic lithotripsy. In addition 72 patients underwent a hepaticojejunostomy. The rate of residual or recurrent stones was 31.4 per cent after complete stone removal. Twenty-two (30.6%) of the 72 patients developed some kind of cholangitis. This rate was significantly higher than that (three of 87 patients) of the non-biliary-enteric anastomosis group regarding the occurrence of biliary complications. We conclude that the use of a hepaticojejunostomy for patients with possible residual stones or intrahepatic bile duct lesions remains controversial.


Subject(s)
Calculi/surgery , Hepatic Duct, Common/surgery , Jejunostomy , Liver Diseases/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Time Factors
6.
Clin Cancer Res ; 5(5): 1107-13, 1999 May.
Article in English | MEDLINE | ID: mdl-10353745

ABSTRACT

Macrophages are key participants in angiogenesis. In this study on human brain tumors, we first investigated whether macrophage infiltration is associated with angiogenesis and malignant histological appearance. Immunostaining of macrophages and small vessels in resected glioma specimens indicated that numbers of infiltrating macrophages and small vessel density were higher in glioblastomas than in astrocytomas or anaplastic astrocytomas. Macrophage infiltration was closely correlated with vascular density in human gliomas. Heme oxygenase-1 (HO-1), which is the rate-limiting enzyme in heme catabolism, was also associated with activated macrophages. Expression of mRNA encoding HO-1 was correlated with macrophage infiltration and vascular density in human glioma samples. Infiltrating macrophages were positively stained with anti-HO-1 antibody by immunohistochemical analysis, and in situ hybridization for HO-1 indicated that HO-1 was expressed in infiltrating macrophages in gliomas. HO-1 gene may be a useful marker for macrophage infiltration as well as neovascularization in human gliomas.


Subject(s)
Brain Neoplasms/blood supply , Glioma/blood supply , Heme Oxygenase (Decyclizing)/analysis , Macrophages/pathology , Neovascularization, Pathologic/pathology , Adolescent , Adult , Aged , Astrocytoma/blood supply , Astrocytoma/enzymology , Astrocytoma/pathology , Blotting, Northern , Brain Neoplasms/enzymology , Brain Neoplasms/pathology , Child , Child, Preschool , Enzyme Induction , Female , Glioblastoma/blood supply , Glioblastoma/enzymology , Glioblastoma/pathology , Glioma/enzymology , Glioma/pathology , Heme Oxygenase (Decyclizing)/genetics , Heme Oxygenase-1 , Humans , In Situ Hybridization , Interleukin-8/analysis , Interleukin-8/genetics , Macrophage Activation , Macrophages/enzymology , Male , Membrane Proteins , Middle Aged , Neovascularization, Pathologic/enzymology , Oligodendroglioma/blood supply , Oligodendroglioma/enzymology , Oligodendroglioma/pathology , RNA, Messenger/analysis
9.
Rev Inst Med Trop Sao Paulo ; 37(4): 357-9, 1995.
Article in English | MEDLINE | ID: mdl-8599067

ABSTRACT

A simple method of rubella antigen production by treatment with sodium desoxycholate for use in enzyme immunoassay (IMT-ELISA) is presented. When this assay was compared with a commercial test (Enzygnost-Rubella, Behring), in the study of 108 sera and 118 filter paper blood samples, 96.9% (219/226) overall agreement and correlation coefficient of 0.90 between absorbances were observed. Seven samples showed discordant results, negative by the commercial kit and positive by our test. Four of those 7 samples were available, being 3 positive by HI.


Subject(s)
Antibodies, Viral/blood , Enzyme-Linked Immunosorbent Assay/methods , Immunoglobulin G/blood , Rubella virus/immunology , Rubella/immunology , Humans , Rubella/diagnosis
10.
Acta Paediatr ; 82(12): 1034-8, 1993 Dec.
Article in English | MEDLINE | ID: mdl-8155920

ABSTRACT

Maternally acquired immunity was studied in 16 pairs of human immunodeficiency virus (HIV)-seropositive women and their newborns, and was compared to 18 control mother-newborn pairs. The HIV-infected women had higher IgG levels than the control subjects, but no difference was observed between newborn samples, presumably due to the limited placental IgG transfer in the HIV group. A poor type 2 poliovirus antibody transfer was also noted in this group. The population of newborns lacking demonstrable measles antibodies was higher in the HIV group than in the control group, probably because many of the HIV-infected mothers lacked measles antibodies also. These results show that maternally acquired immunity may be affected to newborns from HIV-infected women, either because of low maternal serum antibody levels or deficient transplacental transfer. If so, the measles vaccine schedule should be revised for these children and the same should be done for future passive immunization regarding fetus protection in pregnant HIV-seropositive women.


Subject(s)
HIV Seropositivity/immunology , Immunity, Maternally-Acquired , Pregnancy Complications, Infectious/immunology , Adult , Antibodies, Viral/metabolism , Female , Humans , Immunization, Passive , Immunoglobulin G/metabolism , Infant , Measles virus/immunology , Placenta/metabolism , Pregnancy , Vaccination
11.
Nihon Geka Gakkai Zasshi ; 93(9): 1132-4, 1992 Sep.
Article in Japanese | MEDLINE | ID: mdl-1470127

ABSTRACT

Two hundred and three patients with PHL were encountered for the last 10 years. In order to select treatment of PHL, we classified PHL on the basis of atrophy of hepatic parenchyma (AHP), existence of extrahepatic gallstone and dilatation of extrahepatic bile duct (DEBD). For the case with AHP hepatic resection must be performed, because there is often chronic proliferating cholangitis and improvement in hepatic function can not be expected in view of AHP. For the case with extrahepatic gallstone without AHP hepatic resection. For the case with DEBD and without AHP extrahepatic gallstone must be removed. For the patient with extrahepatic gallstone and DEBD without AHP, indication of the removal of stones, depends on the existence of symptoms. Twenty-two cases treated by biliary drainage procedure often had some complications in postoperative course, that is 5 patients had cholangitis and 7 patients liver abscess. It was suggested, therefore, that biliary drainage procedure was contraindicated in PHL.


Subject(s)
Cholelithiasis/surgery , Aged , Atrophy , Bile Duct Diseases/surgery , Drainage/methods , Female , Hepatectomy , Humans , Liver/pathology , Male , Middle Aged
17.
Kango Gijutsu ; 19(10): S: 101-9, 1973 Oct.
Article in Japanese | MEDLINE | ID: mdl-4490754
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