ABSTRACT
Stereoselective acylation of the E,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved by using acid anhydrides and SnCl4. Acid anhydrides having alkyl chains gave the adducts in excellent stereoselectivity. The formal synthesis of khafrefungin has been accomplished by the methodology.
Subject(s)
Acetals/chemistry , Glycolipids/chemical synthesis , Silanes/chemistry , Acylation , Anhydrides/chemistry , Catalysis , Glycolipids/chemistry , Molecular StructureABSTRACT
A catalytic ß-selective addition of amines to styrenes proceeded in the presence of cationic Ru complexes combined with diphosphine ligands. In the reaction of α-methylstyrene, an enantioselective addition was achieved by using xylylBINAP.
ABSTRACT
Ru-catalyzed S(N)Ar reaction of non-activated fluoroarenes with secondary amines proceeded through eta(6)-arene complexes to give aminated products in up to 79% yield.
Subject(s)
Amines/chemistry , Coordination Complexes/chemistry , Fluorobenzenes/chemistry , Ruthenium/chemistry , Catalysis , Coordination Complexes/chemical synthesis , Morpholines/chemistryABSTRACT
Synthesis of naphthalyne-Co2(CO)6 complexes, the first example of the aryne-Co2(CO)6 complex, was achieved via cyclization of acyclic alkyne-Co2(CO)6 complex precursors containing an allylsilane and an aldehyde moiety followed by dehydration. Unique reactivities of the complexes toward oxygen to give carboxylic acid derivatives and toward alkynes to give cyclopentadienone derivatives were also disclosed.
