1.
J Antibiot (Tokyo)
; 39(1): 121-7, 1986 Jan.
Article
in English
| MEDLINE
| ID: mdl-3485088
ABSTRACT
7 beta-[2-(2-Aminooxazol-4-yl)-2-Z-methoximinoacetamido]-3-cep hem -4-carboxylic acids 12 and 13 were synthesized. The microbiological activity of 12 and 13 as well as the beta-lactamase stability of 12 were discussed. Both 12 and 13 were quite active against a wide variety of microorganisms although usually less active than cefotaxime.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Cephalosporins/chemical synthesis , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Cefotaxime/pharmacology , Cephalosporins/pharmacology , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , beta-Lactamases/metabolism
2.
J Antibiot (Tokyo)
; 39(1): 111-20, 1986 Jan.
Article
in English
| MEDLINE
| ID: mdl-3485087
ABSTRACT
A series of 7 beta-[2-(5-aminooxadiazol-3-yl)-2-Z-methoximinoacetamido] -3-cephem-4-carboxylic acids (7a-g) were synthesized and evaluated microbiologically Although somewhat less active than cefotaxime 7a-g showed good antimicrobial activity against a wide variety of Gram-positive and Gram-negative bacteria. The beta-lactamase stability of 7a and 7f was also discussed.
