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Weekly cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer: a well-tolerated alternative.

Giardina, G; Richiardi, G; Danese, S; Ottone, P; Ohlmeier, U; Gargiulo, T.

Eur J Gynaecol Oncol ; 18(3): 173-6, 1997.

Article in English | MEDLINE | ID: mdl-9174829

ABSTRACT

To assess the efficacy and the compliance of weekly cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer, 23 patients, FIGO stage IB-IIA > 4 cm-IIB, were recruited. Treatment consisted of four weekly courses of cisplatin (1.5 mg/kg): 91% of the patients received the planned therapy without dose reduction or delay. Toxicity was mild: delayed emesis was the most common side effect. Overall clinical response rate was 85% with a complete response in 28%. Nineteen patients underwent surgery without any undue increase in morbidity. Histologic analysis of surgical specimens revealed a complete response in 25% of stage IB-IIA patients; in only one case of stage IIB, was residual parametrial involvement present. In conclusion, weekly cisplatin is highly effective, with lower cost and less toxicity compared to other neoadjuvant chemotherapy regimens.

Subject(s)

Adenocarcinoma/drug therapy , Antineoplastic Agents/administration & dosage , Carcinoma, Squamous Cell/drug therapy , Cisplatin/administration & dosage , Uterine Cervical Neoplasms/drug therapy , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Adult , Aged , Antineoplastic Agents/adverse effects , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Chemotherapy, Adjuvant , Cisplatin/adverse effects , Disease-Free Survival , Drug Administration Schedule , Female , Humans , Middle Aged , Neoplasm Metastasis , Neoplasm Staging , Pilot Projects , Prospective Studies , Survival Rate , Treatment Outcome , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/surgery

[Prenatal diagnosis of ileal obstruction using echography]. / Diagnosi prenatale di ostruzione ileale mediante ecografia.

Pagliano, M; Alessandri, A; Gullino, E; Ottone, P L.

Minerva Ginecol ; 38(11): 937-40, 1986 Nov.

Article in Italian | MEDLINE | ID: mdl-3543746

Subject(s)

Fetal Diseases/diagnosis , Ileum/abnormalities , Intestinal Atresia/diagnosis , Prenatal Diagnosis , Ultrasonography , Adult , Female , Humans , Ileal Diseases/diagnosis , Ileal Diseases/etiology , Intestinal Atresia/surgery , Intestinal Obstruction/diagnosis , Intestinal Obstruction/etiology , Pregnancy

[Heterogeneity in cystic hygroma: its implications in genetic counseling]. / L'eterogeneità nell'igroma cistico: sue implicanze nel consultorio genetico.

Gullino, E; Pagliano, M; Ottone, P L; Alessandri, A.

Minerva Ginecol ; 38(7-8): 545-8, 1986.

Article in Italian | MEDLINE | ID: mdl-3528922

Subject(s)

Lymphangioma/genetics , Female , Genetic Counseling , Humans , Karyotyping , Lymphangioma/diagnosis , Pregnancy , Prenatal Diagnosis , Ultrasonography

[Prenatal diagnosis. Indications and risks of early amniocentesis by placental puncture and fetoscopy]. / Diagnosi prenatale. Indicazioni e rischi dell'amniocentesi precoce della puntura placentare e della fetoscopia.

Massobrio, M; Coppo, F; Carozzi, F; De Marchi, M; Migone, N; Ottone, P L; Ansaldi, E; Carbonara, A.

Minerva Ginecol ; 32(6): 527-38, 1980 Jun.

Article in Italian | MEDLINE | ID: mdl-7243054

Subject(s)

Amniocentesis , Fetal Diseases/diagnosis , Fetoscopy , Placenta , Prenatal Diagnosis , Adult , Amniocentesis/adverse effects , Chromosome Aberrations/diagnosis , Chromosome Disorders , Congenital Abnormalities/diagnosis , Female , Genetic Diseases, Inborn/diagnosis , Humans , Pregnancy , Punctures , Risk

[Some aspects of hypothalamo-hypophyseal-gonadal axis function in the testicular feminization syndrome]. / Alcuni aspetti della funzione dell'asse ipotalamo-ipofisi-gonadale nella sindrome di femminilizzazione testicolare.

Massobrio, M; Chiara, G; Ottone, P.

Minerva Ginecol ; 30(3): 125-9, 1978 Mar.

Article in Italian | MEDLINE | ID: mdl-662189

Subject(s)

Androgen-Insensitivity Syndrome/physiopathology , Gonads/physiopathology , Hypothalamo-Hypophyseal System/physiopathology , Adolescent , Adult , Follicle Stimulating Hormone/blood , Humans , Luteinizing Hormone/blood , Testosterone/blood

[Medical treatment of EPH-gestosis]. / Il trattamento medico della gestosi-EPH

Massobrio, M; Genta, F; Ottone, P; Mondo, F.

Ann Ostet Ginecol Med Perinat ; 98(2): 76-96, 1977.

Article in Italian | MEDLINE | ID: mdl-324333

Subject(s)

Pre-Eclampsia/therapy , Adult , Anticonvulsants/therapeutic use , Antihypertensive Agents/therapeutic use , Dextrans/therapeutic use , Diuretics/therapeutic use , Eclampsia/therapy , Edema/therapy , Female , Heparin/therapeutic use , Hospitalization , Humans , Hypertension/therapy , Pre-Eclampsia/diet therapy , Pregnancy , Proteinuria/therapy , Rest , Tranquilizing Agents/therapeutic use , Vasodilator Agents/therapeutic use , Water-Electrolyte Balance

[HPL/HASP correlations in some types of placental pathology]. / Correlazione HPL/HASP in alcuni tipi di patologia placentare

Svanosio, M; Calleri, W; Ottone, P; Massobrio, M.

Ann Ostet Ginecol Med Perinat ; 97(2): 116-21, 1976.

Article in Italian | MEDLINE | ID: mdl-949146

Subject(s)

Alkaline Phosphatase/blood , Placenta Diseases/blood , Placental Lactogen/blood , Female , Humans , Placenta Diseases/enzymology , Pregnancy

[Clinical significance of bilirubin and creatinine in the amniotic fluid]. / Significato clinico della bilirubina e della creatinina el liquido amniotico.

Massobrio, M; Coppo, F; Ottone, P; Trivelli, M R.

Ann Ostet Ginecol Med Perinat ; 93(6): 413-27, 1972 Jun.

Article in Italian | MEDLINE | ID: mdl-4647042

Subject(s)

Amniotic Fluid/analysis , Bilirubin/analysis , Creatinine/analysis , Congenital Abnormalities/diagnosis , Embryonic and Fetal Development , Female , Fetal Diseases/diagnosis , Gestational Age , Humans , Pregnancy , Pregnancy Complications/diagnosis , Prenatal Diagnosis

[Chromosomal abortion]. / L'aborto cromosomico.

Massobrio, M; Coppo, F; Ottone, P.

Minerva Ginecol ; 23(10): 443-72, 1971 May 31.

Article in Italian | MEDLINE | ID: mdl-5098896

Subject(s)

Abortion, Spontaneous/genetics , Chromosome Aberrations , Chromosome Disorders , Abortion, Habitual/etiology , Chromosome Aberrations/complications , Cytogenetics , Female , Genotype , Humans , Karyotyping , Mosaicism , Phenotype , Pregnancy , Trisomy

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