ABSTRACT
HLA-DRB1*09:30 shows a single nucleotide difference from DRB1*09:01:02 at nucleotide 250 (CGGâTGG).
Subject(s)
Alleles , Exons , HLA-DRB1 Chains/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Amino Acid Substitution , Asian People , Base Sequence , Codon/chemistry , Gene Expression , HLA-DRB1 Chains/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
HLA-B*39:119 allele differs from HLA-B*39:01:01:01 by a single nucleotide substitution at position 488.
Subject(s)
Alleles , HLA-B39 Antigen/genetics , Asian People , China , HumansABSTRACT
BACKGROUND: HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug-related SJS/TEN. MATERIALS AND METHODS: A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang. The genetic diversity of the HLA-B*15:02 genes in the ethnic minority samples was examined using sequence based typing at high resolution. RESULTS: The allele frequencies of HLA-B*15:02 in the Yi, Naxi, Miao, Lisu, Derung, Bai, Hani, Dai, and Zhuang populations were 4.25%, 4.4%, 5.09%, 5.77%, 6.33%, 7.82%, 8.15%, 9.6%, and 15.36%, respectively. The frequencies of HLA-B*15:02 carriers in the Yi, Naxi, Miao, Lisu, Derung, Bai, Hani, Dai, and Zhuang populations were 8.5%, 8.8%, 9.58%, 10.9%, 12.65%, 15.64%, 16.3%, 18.69%, and 28.49%, respectively. CONCLUSION: The HLA-B*15:02 allele frequencies indicated that the prevalence of B*15:02 was different among the different ethnic populations. Because the number of carriers of B*15:02 was high in some ethnic populations, larger studies are required to confirm these findings. The Zhuang population had the highest frequency of B*15:02 in this study. More attention should be paid to CBZ-induced SJS/TEN in Chinese minority populations.
Subject(s)
Anticonvulsants/adverse effects , Carbamazepine/adverse effects , Gene Frequency , Genetic Predisposition to Disease , HLA-B15 Antigen/genetics , Stevens-Johnson Syndrome/genetics , Adult , Alleles , Asian People , Blood Donors , China/ethnology , Contraindications, Drug , Ethnicity , Female , Gene Expression , Genetic Variation , HLA-B15 Antigen/immunology , Humans , Male , Stevens-Johnson Syndrome/ethnology , Stevens-Johnson Syndrome/immunology , Stevens-Johnson Syndrome/prevention & controlABSTRACT
HLA-B*46:40:02 has one synonymous nucleotide change from HLA-B*46:40:01 in codon 23, exon 2 (ATT>ATC).
Subject(s)
Alleles , Exons , HLA-B Antigens/genetics , Point Mutation , Tissue Donors , Amino Acid Sequence , Asian People , Base Sequence , Codon/chemistry , Genotype , HLA-B Antigens/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Sequence Alignment , Sequence Analysis, DNAABSTRACT
HLA-B*58:63 differs from HLA-B*58:01:01 by one nucleotide at position 248 resulting in a single amino acid change.
Subject(s)
Alleles , Amino Acid Substitution , HLA-B40 Antigen/genetics , Polymorphism, Single Nucleotide , Asian People , Base Sequence , Bone Marrow Transplantation , Codon , Exons , HLA-B40 Antigen/classification , HLA-B40 Antigen/immunology , Histocompatibility Testing , Humans , Male , Molecular Sequence Data , Protein Isoforms/classification , Protein Isoforms/genetics , Protein Isoforms/immunology , Sequence Alignment , Tissue Donors , Young AdultABSTRACT
The new allele, A*24:289 is different to A*24:03:01 at codons 151, 152 and 156 at exon 3.
Subject(s)
Alleles , Amino Acid Substitution , HLA-A24 Antigen/genetics , Polymorphism, Single Nucleotide , Asian People , Base Sequence , Codon , Exons , Female , HLA-A24 Antigen/classification , HLA-A24 Antigen/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Molecular Sequence Data , Protein Isoforms/classification , Protein Isoforms/genetics , Protein Isoforms/immunology , Sequence Alignment , Tissue Donors , Young AdultABSTRACT
BACKGROUND: The Wenchuan earthquake was a catastrophic earthquake in China. The aim of this study is to explore longitudinally the rates of post-traumatic stress disorder (PTSD) and depression in adolescents after the Wenchuan earthquake, and to identify independent predictors of PTSD. METHOD: PTSD and depression symptoms among adolescents at 6, 12 and 18 months after the Wenchuan earthquake were investigated using the PTSD Checklist Civilian Version and the Beck Depression Inventory (BDI). Subjects in this study included 548 high school student survivors in a local boarding high school. RESULTS: The rates of PTSD symptoms were 9.7%, 1.3% and 1.6% at the 6-, 12- and 18-month follow-ups, respectively. BDI scores were found to be the best predictor of severity of PTSD at 6, 12 and 18 months. Gender was another variable contributing significantly to PTSD at 6 and 12 months after the earthquake. In the 12-month follow-up, home damage was found to be a predictor of severity of PTSD symptoms. Being a child with siblings was found to be a predictor of severity of PTSD symptoms at 12 and 18 months after the earthquake. CONCLUSIONS: PTSD symptoms changed gradually at various stages after the earthquake. Depression symptoms were predictive of PTSD symptoms in the 18-month follow-up study. Other predictors of PTSD symptoms included female gender and being a child with siblings. The results of this study may be helpful for further mental health interventions for adolescents after earthquakes.
Subject(s)
Depression/epidemiology , Earthquakes , Only Child/statistics & numerical data , Stress Disorders, Post-Traumatic/epidemiology , Survivors/statistics & numerical data , Adolescent , Child , China/epidemiology , Female , Humans , Linear Models , Longitudinal Studies , Male , Only Child/psychology , Prevalence , Psychiatric Status Rating Scales , Risk Factors , Severity of Illness Index , Sex Distribution , Siblings , Survivors/psychology , Time FactorsABSTRACT
The relation has not been reported consistently between the polymorphisms in the gene of apolipoprotein A5 (APO A5) and coronary artery disease (CAD). To clarify the discrepancy, we conducted a comprehensive search of PubMed and EMBASE for all available casecontrol studies to explore the association between two APO A5 polymorphisms and CAD. Two reviewers independently selected studies. Statistical analyses were carried out using the STATA software package v 10.0. Thirteen studies investigated the association between the APO A5 -1131T>C polymorphism and risk of CAD were selected in this meta-analysis with 5,050 cases and 7,272 controls. For the S19W APO A5 gene polymorphism, 5 studies were included with 2,196 cases and 3,933 controls. We observed a significant statistical association between Apo A5 -1131T>C polymorphism and CAD (recessive genetic model: OR = 1.73, 95% CI = 1.37-2.19; dominant genetic model: OR = 1.42, 95% CI = 1.25-1.61; allelic contrast: OR = 1.31, 95% CI = 1.22-1.39, respectively). After restricting our analysis to Chinese individuals, we found that the association was stronger. We also observed strong association between the APO A5 S19>W polymorphism and risk of CAD under a recessive genetic model. This meta-analysis reveals that the minor allele of the -1131T>C polymorphism in the promoter of APO A5 gene significantly increases the susceptibility to CAD. This effect is more pronounced in Chinese subjects.
