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1.
Antioxidants (Basel) ; 12(12)2023 Dec 15.
Article in English | MEDLINE | ID: mdl-38136238

ABSTRACT

Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases. As a traditional chemical, silymarin has been widely used in healthcare and clinical applications to treat liver injuries in which ferroptosis is involved. Silibinin is the main active ingredient of silymarin. However, the effect of silibinin on ferroptosis and ferroptosis-related diseases remains unclear. Here, we found that silibinin inhibited death in different kinds of cells caused by ferroptosis inducers including RSL3 and erastin. Moreover, silibinin alleviated lipid peroxidation induced by RSL3 without affecting the labile iron pool. Next, the antioxidant activity of silibinin was demonstrated by the DPPH assay. In vivo, silibinin strikingly relieved tissue injuries and ferroptosis in the liver and kidney of glutathione peroxidase 4 (GPX4) knockout C57 BL/6J mice. Moreover, silibinin effectively rescued renal ischemia-reperfusion, a well-known ferroptosis-related disease. In conclusion, our study revealed that silibinin effectively inhibits cell ferroptosis and ferroptosis-related tissue injuries, implicating silibinin as a potential chemical to treat ferroptosis-related diseases.

2.
J Mater Chem B ; 10(24): 4615-4622, 2022 06 22.
Article in English | MEDLINE | ID: mdl-35642967

ABSTRACT

While it is challenging to simultaneously achieve both high mechanical performance and self-healing ability within one polymer hydrogel network, we, herein, synthesized a novel class of hydrogels based on a combination of chemical and dual non-covalent crosslinks via micellar polymerization of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, end-capped by 2-hydroxyethyl methacrylate (IPDI-HEMA), with acrylamide (AM). The prepared hydrogels were demonstrated to possess a tensile elongation at a break of at least 1900%, a fracture energy of 138.4 kJ m-3, and remarkable self-healing behaviors (e.g., a strong self-healing ability achieved at ambient temperature without the need for any stimulus or healing agent). The multiple crosslinks developed in this study for one polymer hydrogel network are significant steps to construct the desired functional hydrogels with excellent self-healing and mechanical properties.


Subject(s)
Hydrogels , Polymers , Acrylic Resins/chemistry , Hydrogels/chemistry , Polymerization
3.
Cell Death Dis ; 12(7): 706, 2021 07 15.
Article in English | MEDLINE | ID: mdl-34267193

ABSTRACT

Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role of ferroptosis in stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) is a critical suppressor of lipid peroxidation and ferroptosis. Here, we study the function of GPX4 and ferroptosis in hematopoietic stem and progenitor cells (HSPCs) in mice with Gpx4 deficiency in the hematopoietic system. We find that Gpx4 deletion solely in the hematopoietic system has no significant effect on the number and function of HSPCs in mice. Notably, hematopoietic stem cells (HSCs) and hematopoietic progenitor cells lacking Gpx4 accumulated lipid peroxidation and underwent ferroptosis in vitro. α-Tocopherol, the main component of vitamin E, was shown to rescue the Gpx4-deficient HSPCs from ferroptosis in vitro. When Gpx4 knockout mice were fed a vitamin E-depleted diet, a reduced number of HSPCs and impaired function of HSCs were found. Furthermore, increased levels of lipid peroxidation and cell death indicated that HSPCs undergo ferroptosis. Collectively, we demonstrate that GPX4 and vitamin E cooperatively maintain lipid redox balance and prevent ferroptosis in HSPCs.


Subject(s)
Antioxidants/pharmacology , Ferroptosis/drug effects , Hematopoietic Stem Cells/drug effects , Lipid Peroxidation/drug effects , Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism , Vitamin E Deficiency/drug therapy , Vitamin E/pharmacology , Animals , Cells, Cultured , Disease Models, Animal , Female , Hematopoietic Stem Cell Transplantation , Hematopoietic Stem Cells/enzymology , Hematopoietic Stem Cells/pathology , Male , Mice, Inbred C57BL , Mice, Knockout , Phospholipid Hydroperoxide Glutathione Peroxidase/genetics , Vitamin E Deficiency/enzymology , Vitamin E Deficiency/genetics , Vitamin E Deficiency/pathology
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