ABSTRACT
Three new flavonol glycosides (1-3), hippophins K-M, were isolated from the seed residue of Hippophae rhamnoides subsp. sinensis. The chemical structures of these three new compounds were identified by 1D, 2D NMR, mass spectroscopy and high resolution electrospray ionization mass spectrometry spectroscopic data and by comparison with the literature data. This report is a continuous research work on the systematic chemical investigation of plants of the genus Hippophae in our laboratory.
Subject(s)
Drugs, Chinese Herbal/isolation & purification , Flavonoids/isolation & purification , Hippophae/chemistry , Drugs, Chinese Herbal/chemistry , Flavonoids/chemistry , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Seeds/chemistryABSTRACT
Three monoterpenoids and two triterpenoids were isolated from Abies nephrolepis together with 53 known terpenoids. The structures of the compounds were established by 1D and 2D NMR spectroscopy. The absolute configuration of 3-hydroxycamphane-2-carboxylic acid was established as (1S,2R,3S,4R) by Cu-Kα X-ray crystallography. All 58 isolates were tested for cytotoxic activity against four tumor cells viz. A549 (human lung adenocarcinoma), Colo205 (colon adenocarcinoma), QGY-7703 (human hepatoma) and THP-1 (human monocytic leukemia). α-Cadinol exhibited the best effects on A549, Colo205 and QGY-7703 with IC(50) values of 8.6, 8.1 and 4.6 µg/mL, respectively.
Subject(s)
Abies/chemistry , Antineoplastic Agents, Phytogenic/therapeutic use , Camphanes/isolation & purification , Neoplasms/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Terpenes/therapeutic use , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Camphanes/chemistry , Cell Line, Tumor , Humans , Inhibitory Concentration 50 , Molecular Structure , Plant Extracts/chemistry , Plant Extracts/pharmacology , Terpenes/isolation & purification , Terpenes/pharmacologyABSTRACT
The title compound, C(30)H(48)O(3), was extracted from the plant Dracocephalum rupestre Hance. The mol-ecule contains five fused cyclo-hexane rings and one five-membered lactone ring. Inter-molecular O-Hâ¯O hydrogen bonds between the hydroxyl and carbonyl groups link the mol-ecules into chains along [010]. The absolute structure has not been determined.
