ABSTRACT
One of the main causes of the dismal prognosis in patients who survive the initial bleeding after aneurysmal subarachnoidal hemorrhage is the delayed cerebral ischaemia caused by vasospasm. Studies suggest that cerebral magnesium and pH may potentially play a role in the pathophysiology of this adverse event. Using phosphorous magnetic resonance spectrocopy (31P-MRS), we calculated the cerebral magnesium (Mg) and pH levels in 13 patients who suffered from aSAH. The values between the group that developed clinically significant vasospasm (n = 7) and the group that did not (n = 6) were compared. The results of this study show significantly lower cerebral Mg levels (p = 0.019) and higher pH levels (p < 0.001) in the cumulative group (all brain voxels together) in patients who developed clinically significant vasospasm. Further clinical studies on a larger group of carefully selected patients are needed in order to predict clinically significant vasospasm.
ABSTRACT
AIM: To evaluate the clinical outcome and the osseous union of strut onlay allografts (SOAs) used as adjunct in revision total joint arthroplasty (TJA). PATIENTS AND METHODS: Patients that had previously undergone SOA augmentation were considered for inclusion. Patients were invited to provide information for the following: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EuroQol five dimension score (EQ-5D) and Parker mobility score. Osseous union rates between SOA and the host bone were determined by radiograph with the Emerson classification system. Bone mineral density was measured via quantitative computed tomography. RESULTS: Seventeen patients were identified, at a mean follow-up of 2.8 years. The median total WOMAC score was 22 [interquartile range (IQR)=21]. The median EQ-5D score was 0.887 (IQR=0.350) (time trade-off). The Parker Mobility Score was 8.0 (IQR=3.5). Emerson stages of radiographic graft to host union were 'rounding off' in one case, 'partial bridging' in three and 'complete bridging' in 13. Quantitative computed tomography showed an average bone mineral density of approximately 1,300 mg/cm3. CONCLUSION: From our findings, it is concluded that SOAs used in revision total joint arthroplasty provide promising results and are recommended for broader clinical use. A complete osseous union between host and graft bone was observed in the majority of cases.
