Onchocercoma of the scalp: A case report.

Onchocerciasis or river blindness is a parasitic disease caused by Onchocerca volvulus transmitted to humans by the byte of a black fly of the species Simulium. This pathology, which is a part of the Neglected tropical Disease (NTDs), has been resurgent for some years in certain regions of Burkina Faso. We report a case of onchocercoma with the aim of describing the anatomopathological aspects of this pathology. These were two (02) biopsy fragments from a scalp nodule in an 8-year-old boy, received in the pathology laboratory for examination. In this case study, we recall that onchocerciasis is manifested mainly by skin lesions, subcutaneous nodules and ocular lesions. Histologically, the skin lesions present as a dermatitis with adult worms in the superficial dermis within a predominantly eosinophilic inflammatory infiltrate. Nodules or onchocercomas, usually subcutaneous, consist of fibrous, inflammatory tissue with a predominance of eosinophils and adult worms including females containing microfilariae. Ocular lesions begin with punctate keratitis with a snowflake image. Sclerosis with opacification of the cornea progressively sets in, causing blindness.

Epididymal bilharzia simulating a testicular tumor: A case report.

Bilharzia or schistosomiasis is a parasitic disease due to infestation by a hematophagous trematode of the genus Schistosoma. It is the second most frequent parasitic endemic in the world after malaria. The most frequent tissue infections are intestinal and genitourinary. Testicular localizations of schistosoma are very rare. When lesions become chronic, they present as non-specific masses, bilharziomas, posing enormous problems of differential diagnosis with other benign and malignant pathologies, which impacts management. We report a case of epididymal schistosomiasis in a 37 years old patient simulating a malignant tumor. This case allowed us to review the diagnostic difficulties of this rare localization and the challenges of management.

[Diabetes mellitus and high blood pressure over risk in HIV-infected people followed at Souro Sanou University Hospital Day Hospital, Bobo-Dioulasso 2018]. / Sur-risque de diabète sucré et d'hypertension artérielle chez les personnes infectées par le VIH suivies à l'hôpital de jour du CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso, 2018.

BACKGROUND: Non-communicable diseases (NCDs) represent the leading causes of death worldwide. HIV also increases the risk of developing NCDs including diabetes mellitus and hypertension. METHODS: A cross-sectional study, based on an analysis of the cohort database of the day hospital of the Souro Sanou teaching hospital in Bobo-Dioulasso (Burkina Faso). Diabetes mellitus was defined by the undergoing of anti-diabetic treatment or two successive measurements of fasting blood sugar above 7mmol/l and high blood pressure by the undergoing of antihypertensive treatment or two successive measurements of blood pressure above 140/90mmHg. Comparison of the frequency of diabetes and hypertension in the people living with HIV/AIDS (PLWHA) population on antiretroviral therapy (ART) with that of the general population of Burkina Faso was made by indirect standardization according to age and gender. RESULTS: A total of 4259 patients including 3148 women (73.9%) were included in this study. The median age of the patients was 45 years (IQR: 38-52); the median body mass index (BMI) was 19.6kg/m2 (IQR: 15.4 - 22.7) and 48.3% of patients had a BMI≥25kg/m2. The median CD4 count was 590 cells/mm3 (IQR: 417-785). The median ART duration was 8.2 years (IQR: 4.7-11.2). The majority of patients (82.9%) were on treatment combinations consisting in 2 INTI+1 NNRTI. Prevalence of hypertension was 39.8%; it was statistically higher in men than in women (45.8% versus 37.8%). Prevalence of hypertension was 87.0% higher in the PLWHA population than among same-sex and same-age subjects in the general population. Prevalence of diabetes mellitus was 7.3%. Diabetes mellitus was more common in men than in women (10.1% versus 6.3%; P<10-3). Prevalence of diabetes mellitus was 36.0% higher in the PLWHA population than among same-sex and same-age subjects in the general population. CONCLUSION: Prevalence of diabetes mellitus and hypertension was higher among PLHWA undergoing ART than in the general population. Care for the PLHWA population should more widely include NCD treatment.

[Repressive medical responsability: opinion of practitioners and users of the hospital, case of CHU Yalgado Ouédraogo in Burkina Faso]. / Responsabilite medicale repressive : avis des praticiens et des usagers de l'hopital, cas du CHU Yalgado Ouedraogo au Burkina Faso.

MATERIAL AND METHOD: A cross-sectional study on medical responsability for repressive purposes: the opinion of practitioners and users of the hospital, was carried out from 1 April to 30 June 2017 using an anonymous individual questionnaire 271 practitioners and users of CHU Yalgado Ouedraogo. RESULTS: The study population was young. The mean age of hospital users was 38.68 years, that of practitioners was 32.26 years. Hospital users think in 56.1% of cases (152) that a practitioner can be sued for punishment. Of these, criminal responsibility was the most cited by hospital users in 51%. Users who felt that they had been the victim of medical malpractice numbered 36 or 13.3%. None of these 36 users had filed a lawsuit complaint. Disciplinary responsibility was most cited by practitioners in 44% of cases. Practitioners who cited both criminal and disciplinary responsability were 65 or 24%. Practitioners who claim to have been the source of medical malpractice are 03 (1.1%).

MATÉRIEL ET MÉTHODE: Une étude transversale portant sur la responsabilité médicale à visée répressive, avis des praticiens et des usagers de l'hôpital, a été réalisée du 1er Avril au 30 Juin 2017 à l'aide d'un questionnaire individuel anonyme, auprès de 271 praticiens et usagers du CHU Yalgado Ouédraogo. RÉSULTATS: L'âge moyen des usagers de l'hôpital était de 38,68 ans, celui de praticiens était de 32,26 ans. Les usagers de l'hôpital pensent dans 56,1% des cas (152) qu'un praticien peut être poursuivi en justice pour être sanctionné. Parmi ces derniers, la responsabilité pénale était la plus citée par les usagers de l'hôpital dans 51%.Les usagers qui estimaient avoir été victime d'une faute médicale étaient au nombre de 36 soit 13,3%.Aucun de ces 36 usagers n'avait déposé une plainte pour poursuite judiciaire. La responsabilité disciplinaire était la plus citée par les praticiens dans 44% des cas. Les praticiens qui ont cité à la fois la responsabilité pénale et disciplinaire, étaient au nombre 65 soit 24%. Les praticiens qui déclarent avoir été à l'origine d'une faute médicale sont au nombre de 03 soit 1,1%.

Responsabilité médicale répréssive: avis des praticiens et des usagers de l'hôpital, cas du CHU Yalgado Ouedraogo au Burkina Faso

Matériel et méthode:Une étude transversale portant sur la responsabilité médicale à visée répressive, avis des praticiens et des usagers de l'hôpital, a été réalisée du 1er Avril au 30 Juin 2017 à l'aide d'un questionnaire individuel anonyme, auprès de 271 praticiens et usagers du CHU Yalgado Ouédraogo.Résultats: L'âge moyen des usagers de l'hôpital était de38,68 ans, celui de praticiens était de 32,26 ans.Les usagersde l'hôpital pensent dans 56,1% des cas (152) qu'un praticien peut être poursuivi en justice pour être sanctionné. Parmi ces derniers,la responsabilité pénale était la plus citée par les usagers de l'hôpital dans 51%.Les usagers qui estimaient avoir été victime d'une faute médicale étaient au nombre de 36 soit13,3%.Aucun de ces 36 usagers n'avait déposé une plainte pour poursuite judiciaire.La responsabilité disciplinaire était la plus citée par les praticiens dans 44% des cas.Les praticiens qui ont cité à la fois la responsabilité pénale et disciplinaire, étaient au nombre65soit 24%.Les praticiens qui déclarent avoir été à l'origine d'une faute médicale sont au nombre de03soit 1,1%

[Characteristics of Low-Level Persistent viraemias in HIV-1 Patients Treated with Second-Line ARVs at the Sourô Sanou Teaching Hospital of Bobo-Dioulasso (Burkina Faso)]. / Caractéristiques des virémies persistantes de bas niveau des patients VIH-1 sous traitement antirétroviral de deuxième ligne au CHU Sourô Sanou de Bobo-Dioulasso (Burkina Faso).

We describe the characteristics of patients infected with HIV-1 as second-line antiretroviral therapy, with persisting low-level viremia. This was a descriptive retrospective study, conducted from January 1, 2010 to December 31, 2016, from the Cohort of the Infectious Diseases Department of Bobo-Dioulasso University Hospital. Patients infected with HIV-1, a second line of stable ARV treatment, with ≥95% compliance for at least 12 months, asymptomatic with CVp between 50 and 1000 copies/ml in two consecutive samplings at least 3 months apart. Out of 244 patients in second-line therapy, 79 met our inclusion criteria. The mean age of the patients was 42±10.2 years. Women (35.8 years) were younger than men (43.8 years) (p=0.001). Most were married (48.1%), 23.5% of whom were polygamous. The majority of patients (38/79) in the study had a CD4 count of <200 cells/ mm3. The median duration of ARV therapy since the beginning of the therapeutic history has been 4.8 (2.5-11 years). CVp greater than 10,000 copies/ml at the start of second-line therapy (p=0.003) and TDF+FTC + DRV + RTV combination (p=0.001) were associated with persistent low viremia. A genotypic resistance test is needed for these patients in order to better adapt the ARV treatment.

Nous décrivons les caractéristiques des patients infectés par le VIH-1 en deuxième ligne de traitement antirétroviral, avec une virémie persistante de bas niveau. Il s'agissait d'une étude rétrospective à visée descriptive, menée du 1er janvier 2010 au 31 décembre 2016, à partir de la cohorte du service des maladies infectieuses du CHU de Bobo-Dioulasso. Ont été inclus les patients infectés par le VIH-1, en deuxième ligne de traitement ARV stable, ayant une observance ≥ 95 % depuis au moins 12 mois, asymptomatiques, avec une charge virale plasmatique comprise entre 50 et 1 000 copies/ml sur deux prélèvements consécutifs à au moins 3 mois d'intervalle. Sur 244 patients en deuxième ligne de traitement antirétroviral, 79 répondaient à nos critères d'inclusion. L'âge moyen des patients était de 42 ± 10,2 ans. Les femmes (35,8 ans) étaient moins âgées que les hommes (43,8 ans) (p = 0,001). La plupart des patients étaient mariés (48,1 %), parmis lesquels certains vivaient dans des régimes polygames (23,5 %). La majorité des patients (38/79) de l'étude avaient un taux de CD4 ≤ 200 cellules/mm3. La durée médiane du traitement ARV depuis le début de l'histoire thérapeutique était de 4,8 ans (2,5- 11 ans). La charge virale plasmatique supérieure à 10 000 copies/ml au début du traitement (p = 0,003), et la combinaison TDF+FTC+DRV+RTV (p = 0,001) étaient associées à la virémie persistante de bas niveau. La réalisation d'un test génotypique de résistance s'impose pour ces patients afin de mieux adapter le traitement antirétroviral.

Acute appendicitis due to schistosomiasis: four cases at the Yalgado Ouédraogo University Hospital of Ouagadougou.

Acute appendicitis is a frequent pathology with diverse causes. Although Burkina Faso is a tropical country with endemic schistosomiasis, bilharzial appendicitis remains rare. We report 4 cases of appendicitis due to schistosomiasis that we treated at the university hospital of Yalgado Ouédraogo to call attention to the need for routine review of appendectomy parts. Four male patients, aged 22, 26, 30, and 35 years old, were admitted for abdominal pains. Eosinophilia was observed in one case. The preoperative diagnosis was acute appendicitis in 2 cases and appendiceal peritonitis in 2 others. Appendectomy was performed in all cases. Pathological examination of the appendectomy piece observed acute suppurative appendicitis due to schistosomiasis, specifically, Schistosoma haematobium. All patients received praziquantel for antiparasite treatment. Clinical course was uncomplicated in all cases. Routine antiparasite treatment would make it possible to prevent these cases of bilharzial appendicitis. In addition, routine histologic examination of appendectomy parts would enable us to determine the real frequency of this disease in our country, where bilharziasis is endemic. The treatment is appendectomy and the prognosis is good.

Emergence and spread of antibiotic resistance in West Africa : contributing factors and threat assessment.

The emergence and spread of antibiotic resistance present a major public health issue in both developed (DC) and less developed countries (LDC). Worldwide, its main cause is the uncontrolled and unjustified use of antibiotics. In countries with limited resources, such as West African nations, other features, more specifically socioeconomic and behavioral factors, contribute to exacerbate this problem. The objective of this review is to give an update of the common and specific factors involved in the amplification of antibiotic resistance phenomena in LCD, particularly in West African countries. In particular, some frequent societal behaviors (such as self-medication), inadequate healthcare infrastructure (insufficiently trained prescribers and inadequate diagnostic tools), and an uncontrolled drug sector (antibiotics sold over-the-counter, improperly stored, counterfeit, and/or expired) all strongly promote the emergence of antibiotic resistance. This risk is particularly worrisome for enterobacteriaceae producing extended spectrum beta-lactamases (10 to 100 % of colonizations and 30 to 50 % of infections). A similar trend has been observed for carbapenem resistance in enterobacteriaceae with rates ranging from 10 to 30 % and for methicillin resistance in Staphylococcus aureus, which now exceeds 30 %. These troubling observations call for effective health policies in these regions. These intervention strategies must be integrated and simultaneously target policy makers, prescribers, and users.

[Factors associated with the satisfaction of prescribers of blood products in Burkina Faso]. / Facteurs associés à la satisfaction des prescripteurs de produits sanguins labiles au Burkina Faso.

BACKGROUND: The National Blood Transfusion Centre, unique operator of blood transfusion in Burkina Faso is engaged into the quality process according to ISO 9001. Therefore, the assessment of customer satisfaction is a main part of its system. Our study conceives "customer satisfaction" as dependant to the perceived service quality based on SERVQUAL model. OBJECTIVES: To identify factors associated with the satisfaction of blood products prescribers in order to help decision-makers for continuous improvement of services. MATERIAL AND METHODS: We conducted a cross-sectional survey among prescribers of blood components in Ouagadougou, between February 27 and April 30, 2015. We used an anonymous self-administered questionnaire, including 13 items associated to the 5 dimensions of SERVQUAL model. The different satisfaction gaps were calculated and linear regression was used to determine statistical associations with a significance level of 5%. RESULTS: The return rate was 94.5% about the 256 questionnaires distributed. A total of 30% of respondents were satisfied to very satisfied. The overall global gap of satisfaction was -5.74. The product delivery time, the efficacy and safety of blood products, the medical and clinical support, the pro-activity of the communication, the management of blood products reservation and the satisfaction of needs in blood products were the factors associated with the prescribers' satisfaction. CONCLUSION: This first study in blood transfusion services in our context was been useful to assess customer satisfaction and identify the main axes on which targeting priority actions in order to effectively use available resources.

[Serological markers of viral hepatitis B and C in children with sickle cell disease monitored in the Pediatrics Department at the University Hospital of Bobo-Dioulasso (Burkina Faso)]. / Étude des marqueurs sérologiques des hépatites virales B et C chez les drépanocytaires suivis en pédiatrie au CHU de Bobo-Dioulasso (Burkina Faso).

Viral hepatitis B and C are universal public health problems. Burkina Faso is a high endemic area for hepatitis B. Patients with sickle cell disease are at risk. The aim of this study was to investigate and quantify the serological markers of viral hepatitis B and C among pediatric patients with sickle cell disease. This was a descriptive cross-sectional study, which took place from July to November 2014 at the Department of Pediatrics, University Hospital of Bobo- Dioulasso. The study included 44 SS and 26 SC sickle cell patients. General data (age, gender) and medical information (vaccinations, medical history including transfusion) were collected. Blood samples were taken for research and titration of serological markers of hepatitis viruses B and C with a commercial Elisa test on the ARCHITECT i1000® automat of Abbott Laboratories. The mean age of the patients was 7.98 years. Seventeen patients (13 SS and SC 4) had already been transfused at least once. The transfusion rate was significantly higher among the SS patients than among SC (29.5% and 15.3% respectively) patients. No patient with HBs Ag was been found. In two patients, the anti-HBc Ab was found alone. In 33% of cases, no markers of hepatitis B were found. Less than 20% of children fully vaccinated (N = 45) had a protective level of anti-HBs Ab (greater than 10 IU/l). The prevalence of anti-VHC Ab was 2.8%. No case of HBV-HCV co-infection was found. The prevention of infection is an important part of the management of sickle cell patients. Immunization against hepatitis B should be systematic. The results of this study assume that blood safety was good.

[Survival of malignant and paramalignant pleural effusions in Ouagadougou]. / Survie des pleurésies malignes et paramalignes à Ouagadougou.

This study aimed to present the survival of patients with malignant and paramalignant pleural effusion (MPE) in a context of resource-limited countries. We retrospectively studied patients received for malignant and paramalignant pleural effusion in three health facilities in Ouagadougou from 1st August 2009 to 30 July 2015. Survival was analyzed according to various characteristics related to patients and disease. Eighty patients with a mean age of 54 years were selected. The sex-ratio was 0.9. Sixteen patients had comorbidities. Pleural effusion was revealing, synchronous and metachronous in respectively 55 %, 26.3 % and 17.5 % of cases. Lung cancer was the most common cause of MPE (27.5 %), followed by breast cancer (18.7 %). The median overall survival was 3 months; it varied between primary cancers: 5 months for primary cancer unknown, 4 months for lung cancers and 2 months for breast cancers. Sex and the presence of comorbidities were independent factors influencing survival of patients. In this study, patient survival length is strongly compromised by inadequacies of medical technical equipment.

Microbiological characteristics of community-acquired peritonitis at Souro Sanou Teaching Hospital of Bobo Dioulasso.

The purpose of this study was to describe the microbiological characteristics of community-acquired peritonitis at the Souro Sanou teaching hospital of Bobo Dioulasso, Burkina Faso. This 10-month prospective study, from July 2012 through May 2013 included all cases of community-acquired peritonitis who underwent surgery at our hospital and had a pus sample taken at that time. Bacteriological analyses were performed according to the hospital laboratory's protocol. The study included 72 patients (45 men and 27 women with a sex-ratio of 1.6). Their mean age was 27.3 years (range: 14 months to 67 years). The analysis of 72 samples of pus enabled confirmation of 39 cases and led to the identification of 53 bacterial strains. The most common families were enterobacteriaceae in 58% and Gram-positive cocci in 36%. The most common enterobacteria species was Escherichia coli (47%) followed by Streptococcus species (22%). The microbiological confirmation of peritonitis was most frequent in the 20-30 year-old age group. These bacteria appeared most susceptible to gentamycin, ceftriaxone, and ciprofloxacin, while we observed resistance to amoxicillin and the combination of clavulanic acid-amoxicillin. These findings suggest that the best probabilistic antibiotic treatment for the peritonitis in our context would combine a third-generation cephalosporin with aminoglycosides, with imidazole to cover potential anaerobic bacteria.

[Evaluation of stool microscopy and culture to assist the diagnosis of pulmonary tuberculosis in a tuberculosis endemic country]. / Évaluation de la microscopie et de la culture des selles dans le diagnostic de la tuberculose pulmonaire dans un pays d'endémie tuberculeuse.

OBJECTIVE: the aim of this study is to evaluate the performance of stool microscopy and culture in the diagnosis of pulmonary tuberculosis (PTB). MATERIAL AND METHOD: In resource-limited settings, PTB is mainly diagnosed in sputum by microscopy methods. In patients unable to provide sputum, invasive procedures are necessary to obtain alternative respiratory tract specimens. Because Mycobacterium tuberculosis complex (MTC) organisms are known to survive in gastric fluid, we hypothesized that swallowed MTC organisms would be detectable in stool samples. We compared the presence of MTC organisms in sputum and stool specimens collected at the same time from the same patients. RESULTS: We included samples routinely submitted to our laboratory of microbiological diagnosis from patients with suspected PTB. In addition, a stool specimen was collected within 24 h of the sputum collection or gastric aspirate. In the 57 patients included, sputum microcopy and culture confirmed respectively 9 (21%) and 15 (26%) cases. Stool samples made it possible to confirm 9 cases by microscopy and 5 cases by culture. The sensitivity of microscopy was 60% and that of culture 33%. Sputum analysis was negative for one HIV-infected patient, but the stool sample was positive and permitted the diagnosis of PTB. CONCLUSION: This study proves that despite the low sensitivity of stool cultures it can be an alternative or additional interesting sample for the diagnosis of PTB in patients who have difficulty expectorating.

[Epidemiological and clinical profile of cerebral palsy at the Bobo-dioulasso university hospital (Burkina Faso)]. / Profil epidemiologique et clinique des infirmites motrices cerebrales au centre hospitalier universitaire de Bobo-dioulasso (Burkina Faso).

INTRODUCTION: Cerebral palsy is the leading cause of motor disability in children. OBJECTIVE: To describe the epidemiological and clinical profiles of cerebral palsy in children seen at the of Bobo-Dioulasso University Hospital. POPULATION AND METHODS: This is a descriptive cross-sectional study prospectively conducted at the Department of Physical Medicine at the University Hospital of Bobo-Dioulasso over a period of one year from 1 July 2012 to 30 June 2013. Our study population consisted of all children aged between 0 and 15 years received during the study period displaying cerebral palsy symptoms. RESULTS: We studied 174 patients including 106 boys and 68 girls. The average age was 32.79 months. Etiological factors were dominated by prematurity (34.5%) and cerebral anoxia (25.86%). The main clinical presentations were diplegia (50%), quadriplegia (19.54%), hemiplegia (14.37%), monoplegia (10.34%) and triplegia (5.75%). The most common associated symptoms were epilepsy (15%), eye disorders (12.6%), and hearing problems (10%). CONCLUSION: Due to its frequency and disabling potential, cerebral palsy is a major public health problem in Burkina Faso. Its support in the African environment is heavily complicated by self-medication and traditional therapy.

INTRODUCTION: L'infirmité motrice cérébrale est la première cause du handicap moteur chez l'enfant. OBJECTIF: Décrire les profils épidémiologique et clinique de l'infirmité motrice cérébrale chez les enfants vus en consultation au Centre Hospitalier Universitaire de Bobo-Dioulasso. MATÉRIEL ET MÉTHODE: Il s'est agi d'une étude transversale descriptive à collecte prospective conduite dans le service de médecine physique du Centre Hospitalier Universitaire de Bobo-Dioulasso sur une période d'un an, allant du 1er Juillet 2012 au 30 Juin 2013. Notre population d'étude se composait de tous les enfants âgés de 0 à 15 ans, reçus en consultation durant la période de l'étude et présentant un tableau d'infirmité motrice cérébrale. RÉSULTATS: L'analyse a concerné 174 patients dont 106 garçons et 68 filles. L'âge moyen à l'inclusion était de 32,79 mois. Les facteurs étiologiques étaient dominés par la prématurité (34,5%) et l'anoxie cérébrale (25,86%).Les principaux tableaux cliniques étaient la diplégie (50%),la tétraplégie (19,54%),l'hémiplégie (14,37%), la monoplégie (10,34%) et la triplégie (5,75%). Les signes associés les plus fréquents étaient les crises comitiales (15%), les troubles oculaires (12,6%), les difficultés auditives (10%). CONCLUSION: De par sa fréquence et son potentiel incapacitant, l'infirmité motrice cérébrale constitue un problèmemajeur de santé publique au Burkina Faso.Sa prise en charge en milieu africainest lourdement grevée par l'automédication et la tradithérapie.

Profil epidemiologique et clinique des infirmites motrices cerebrales au centre hospitalier universitaire de Bobo-Dioulasso (Burkina Faso)

Introduction : L'infirmite motrice cerebrale est la premiere cause du handicap moteur chez l'enfant. Objectif : Decrire les profils epidemiologique et clinique de l'infirmite motrice cerebrale chez les enfants vus en consultation au Centre Hospitalier Universitaire de Bobo-Dioulasso. Materie( et methode : Il s'est agi d'une etude transversale descriptive a collecte prospective conduite dans le service de medecine physique du Centre Hospitalier Universitaire de Bobo-Dioulasso sur une periode d'un an; allant du 1er Juillet 2012 au 30 Juin 2013. Notre population d'etude se composait de tous les enfants ages de 0 a 15 ans; recus en consultation durant la periode de l'etude et presentant un tableau d'infirmite motrice cerebrale. Resu(tats : L'analyse a concerne 174 patients dont 106 garcons et 68 filles. L'age moyen a l'inclusion etait de 32;79 mois. Les facteurs etiologiques etaient domines par la prematurite (34;5%) et l'anoxie cerebrale (25;86%).Les principaux tableaux cliniques etaient la diplegie (50%);la tetraplegie (19;54%);l'hemiplegie (14;37%); la monoplegie (10;34%) et la triplegie (5;75%). Les signes associes les plus frequents etaient les crises comitiales (15%); les troubles oculaires (12;6%); les difficultes auditives (10%). Conc(us ion : De par sa frequence et son potentiel incapacitant; l'infirmite motrice cerebrale constitue un problememajeur de sante publique au Burkina Faso.Sa prise en charge en milieu africainest lourdement grevee par l'automedication et la traditherapie

[Impact of a conjugated anti meningococcal A vaccine on notification of bacterial meningitis in West Burkina Faso (2009-2012)]. / Impact d'un vaccin conjugué antiméningococcique « A ¼ sur les méningites bactériennes notifiées à l'ouest du Burkina Faso (2009-2012).

Burkina Faso is a sub-saharan African country completely included in the meningococcal meningitis belt. The western part of the country suffered from many meningococcal A epidemics, in spite of reactive collective campaigns with polysaccharide A vaccine. On 6th December 2010, Burkina Faso was the first African country to conduct a collective vaccination campaign of all the 1-29 years old population with a new conjugated meningococcal Avaccine (MenAfriVac™). Before this campaign, in Western Burkina (4,064,928 inhabitants, 27.5% of total population), a rehearsal of the staff of all peripheral medical laboratories has been conducted, with delivery of laboratory equipment, reactants, and possibility to transfer CSF specimens at the central level to confirm bacteriologic species in cause by latex, culture and PCR analysis. For this campaign, an administrative coverage of 100.3% was reached. A nearly complete disappearance of meningitis due to meningococcus A was recorded, but an increase of cases due to meningococcus X, W135. With the increase of quality of surveillance, and MenAfriVac™ vaccination showed its beneficial effect on meningococcus A meningitis. If we want however to impact on the number of recorded acute bacteriological meningitis, we will have to use multi-antigenic, if possible conjugated, meningococcal vaccines against locally circulating meningococcal species, the number of pneumococcal meningitis being contained by the recent inclusion in EPI of a 13-valent conjugated pneumococcal vaccine.

[Prevalence of anti-CMV antibodies in blood donors in Ouagadougou (Burkina Faso)]. / Prévalence des anticorps anti-cytomégalovirus chez les donneurs de sang de Ouagadougou (Burkina Faso).

The aim of our study was to investigate the prevalence of CMV antibodies among blood donors at a regional blood transfusion center in Ouagadougou. Blood collected from 115 donors was tested for specific anti-CMV antibodies as well as routine markers. The donors ranged in age from 18 to 53 years (mean: 28.78 ± 8.9 years), and 72.2% were men. In all, 4.3% were positive for HIV, 12.2% for HBs Ag, 2.6% for HCV, and 1.7% for syphilis. Nearly all donors (n=106, 92.2%) had CMV IgG antibodies, but only 12.2% (n=14) IgM antibodies, and all of the latter were also positive for IgG. CMV infection was not related to the donors' HIV status (p=0.66). The seroprevalence of CMV infection was not statistically related to gender, age or occupational status. There was no significant difference in the prevalence of any routine markers between donors positive and negative for CMV. The high rate of CMV antibodies indicates that CMV infection is widespread in Burkina Faso. Although it is thus unnecessary to test blood donors routinely for CMV, immunodepressed and other risk subjects should receive CMV-negative or leukocyte-depleted blood.

[Impact of vaccination on admissions for Haemophilus influenzae b meningitis from 2004 to 2008 in Bobo Dioulasso, Burkina Faso]. / Impact de la vaccination sur la méningite à H. influenzae b de 2004 à 2008, à Bobo Dioulasso (Burkina Faso).

OBJECTIVE: Vaccination against Haemophilus influenzae type b was introduced in Burkina Faso on 1st January 2006. This study thus sought to determine the impact of the first 30 months of vaccination on admissions for Hib meningitis in the department of pediatrics at the Sourô-Sanou University Hospital in Bobo Dioulasso. METHODS AND PATIENTS: Retrospective study of children aged zero to 14 years hospitalized from 1st January 2004 to 30th June 2008 for acute bacterial meningitis (laboratory-confirmed). RESULTS: During the study period, 416 children were admitted for acute bacterial meningitis. The bacterium isolated was identified in 386 cases and unidentified in 30 cases. Hib meningitis accounted for 42.3 % of the cases of identified bacterial meningitis before the introduction of the vaccine (2004 to 2005). This rate declined to 11.8 % for the first 30 months of vaccination (p < 0.001). No cases of Hib meningitis have been reported in the first half of 2008. CONCLUSION: Admissions for Hib meningitis in the Department of Pediatrics have practically disappeared two years after the introduction of the Hib vaccine into Burkina Faso's expanded program on immunization.