Subject(s)
Dermatomycoses/complications , Foot Dermatoses/microbiology , Hand Dermatoses/microbiology , Microsporum , Tinea Capitis/microbiology , Antifungal Agents/therapeutic use , Child, Preschool , Dermatomycoses/drug therapy , Dermatomycoses/microbiology , Female , Foot Dermatoses/drug therapy , Griseofulvin/therapeutic use , Hand Dermatoses/drug therapy , Humans , Tinea Capitis/drug therapyABSTRACT
The pathogenic mechanisms underlying Schizophrenia (SZ), one of the most frequent mental disorders, are complex and poorly understood. Several evidences suggest that inflammatory processes may underpin some of its neurobiological correlates. The aim of this study was: (i) to analyze the potential association between circulating levels of the C-reactive protein (CRP), a crucial inflammatory marker, and Schizophrenia in Tunisian patients and healthy controls (HC) cohorts; (ii) to investigate the genetic diversity of three CRP variants (rs1417938, rs1130864 and rs1205) and; (iii) to analyze a potential relationship between expression and genetic data and clinical and socio demographical characteristics. CRP polymorphisms were exanimated for 155 patients and 203 HC by taqMan5'-nuclease. High-sensitivity CRP (hs-CRP) serum level was measured in 128 clinically stable out-patient SZ patients and 63 HC subjects via an automated biochemical analyzer. We found that hs-CRP levels were significantly higher in SZ patients as compared to HC. No significant differences were found when the proportions of CRP variants were compared in patients and HC. Further analysis according to clinical and socio demographical characteristics revealed a positive association with age and hypertension. Our data on an original Tunisian sample confirm the previous finding in others population groups.
Subject(s)
C-Reactive Protein/analysis , Schizophrenia/blood , Schizophrenia/epidemiology , Adolescent , Adult , Aged , Biomarkers/analysis , Biomarkers/blood , C-Reactive Protein/metabolism , Case-Control Studies , Cohort Studies , Disease Susceptibility , Female , Humans , Male , Middle Aged , Risk Factors , Schizophrenia/etiology , Tunisia/epidemiology , Young AdultABSTRACT
Obesity induces many organic complications (somatic, metabolic and mechanical). The aims of this prospective study were to evaluate its complications in a group of thirty fat patients. Fatty liver disease, detected by echography is noted at 70% of patients. Clinically, it makes pains at the right side and seems favorized by an elevated BMI > 40 kg/m2, and diabetes, hypertriglyceridemiae, hypercaloric and hyperglucidic ration. 10% of our patients present stone bile duct associated to fatty liver disease.
