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1.
Mali Med ; 36(4): 73-74, 2021.
Article in French | MEDLINE | ID: mdl-38200717

ABSTRACT

Cystic meningioma of the falx is a rare extra-axial tumor, representing 4 to 7% of all intracranial meningioma. We report the case of a 23 years old patient with relative personal health history who has presented for nearly two years generalized headache associated with left hemiparesis. The head CT scan and MRI showed a right posterior parietal tumor with a cystic and fleshy component which was interpreted as glioma. The patient was operated and the intraoperative aspect was an extra axial lesion inserted to the middle tier of the falx cerebri with a clear cleavage plan with the cerebrum. A total ablation of the lesion was down and the histological study confirm the diagnosis. The cystic meningioma is a rare variant of intracerebral meningioma of which only histology makes it possible give the diagnosis of certainty.


Le méningiome kystique de la faux est une tumeur extra-axiale rare, représentant 4 à 7% des méningiomes intracrâniens. Nous rapportons le cas d'une patiente de 23 ans aux antécédents personnels de santé relative qui présentait depuis près de deux ans des céphalées généralisées associées à un déficit de l'hémicorps gauche. Le scanner et l'IRM préopératoire ont montré un processus tumoral pariétal postérieur droit avec une double composante kystique et charnue qui a été interprétée en préopératoire comme gliome. La patiente a été opérée et l'aspect peropératoire était celui d'une lésion extra-axiale insérée aux tiers moyen de la faux du cerveau avec un plan de clivage franc avec le cerveau adjacent. Une exérèse totale de la lésion est réalisée et l'étude histologique a confirmé le diagnostic. Le méningiome kystique est une variante rare de méningiome intracrânien dont seule l'histologie permet de donner le diagnostic de certitude.

2.
Rev Neurol (Paris) ; 165(10): 821-7, 2009 Oct.
Article in French | MEDLINE | ID: mdl-19362726

ABSTRACT

Anticonvulsant hypersensitivity syndrome (AHS) is defined by the association of high fever, cutaneous rash and multiorgan-system abnormalities (incidence, one in 1000 to one in 10,000 exposures). Fatal complications are described in 10%. This reaction usually develops 1 to 12 weeks after initiation of an aromatic anticonvulsant. Drug rash with eosinophilia and systemic symptoms (DRESS) can be discussed as differential diagnosis. Several hypotheses have been put forward to explain the pathogenesis of AHS. These include accumulation of toxic metabolites, antibody production and viral infection. The one based on toxic metabolites has found the greatest acceptance due to the fact that it can be proven by an in vitro test, the lymphocyte toxicity assay. In vivo, skin biopsies show characteristic findings of erythema multiform or typical leucocytoclastic angitis. The patch-test is positive in 80% of the cases. Lamotrigine-associated anticonvulsant hypersensitivity syndrome (LASH) is rare and was described in 1998. We report two new cases demonstrating the two particular configurations of apparition of LASH found in the 14 cases from the review of literature (Pubmed: anticonvulsant hypersensitivity syndrome - lamotrigine): high doses of lamotrigine (or lamotrigine in very young or old patients), and lamotrigine associated with another anti-epileptic (phenobarbital or sodium valproate). We discuss the links between DRESS after lamotrigine and LASH as illustrated in a new case.


Subject(s)
Anticonvulsants/adverse effects , Drug Hypersensitivity/physiopathology , Triazines/adverse effects , Adult , Aged , Anticonvulsants/therapeutic use , Bipolar Disorder/complications , Drug Eruptions/physiopathology , Eosinophilia/chemically induced , Eosinophilia/physiopathology , Epilepsy/complications , Epilepsy/drug therapy , Epilepsy, Generalized/complications , Epilepsy, Generalized/drug therapy , Epilepsy, Tonic-Clonic/complications , Epilepsy, Tonic-Clonic/drug therapy , Female , Fever/chemically induced , Fever/physiopathology , Humans , Lamotrigine , Male , Phenobarbital/adverse effects , Phenobarbital/therapeutic use , Syndrome , Triazines/therapeutic use
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