[Platelet aggregation in diabetes mellitus in children]. / Etude de l'agrégation plaquettaire au cours du diabète sucré de l'enfant.

Platelets-endothelial cells interaction appears to cause vascular damage in diabetes. Platelet aggregation was studied in 24 diabetic children and adolescents (mean age: 12.2 years, mean duration of diabetes: 3.3 years), with only one presenting microangiopathy complications (retinopathy). Platelet aggregation was found to be normal, suggesting that there is usually no platelet hyperactivity in diabetic children.

[The association of diabetes and celiac disease: the value of assaying antireticulin antibodies]. / Association diabète et maladie coeliaque: intérêt du dosage des anticorps antiréticuline.

The authors studied the specificity and the sensitivity of serum anti-reticulin IgA type antibody determination for the diagnosis of coeliac disease in diabetic patients. They observed a frequency of 11.1% coeliac disease among a group of 54 type I juvenile diabetic patients. The search for serum antireticulin IgA type antibodies appears to be an efficient method for identifying patients with coeliac disease; it has a specificity of 98% and a sensitivity of 95%. This marker appears to be particularly well suited for the identification of asymptomatic forms, and also for surveillance of diet during the course of coeliac disease.

[Evaluation of the assay of serum fructosamine in the surveillance of diabetes in children and adolescents]. / Evaluation du dosage de la fructosamine sérique dans la surveillance du diabète de l'enfant et de l'adolescent.

Serum fructosamine and glycosylated haemoglobin were measured 4 times over 2 month period (1st, 15th, 30th and 60th days) in 40 young diabetics and in 26 controls. A positive correlation was found between these two parameters at the 15th, 30th and 60th days (0.44 less than r less than 0.61, P less than 0.01). There was a milder correlation between glycosylated haemoglobin and fasting glycemia (r = 0.43), between serum fructosamine and mean glycemia of the last 4 weeks (r = 0.38) and between serum fructosamine and 24 h glycosuria (r = 0.39) (P less than 0.05). Serum fructosamine, which reflects the mean glycemia of the last 3 weeks appears as a useful parameter in diabetic control, in association with glycosylated haemoglobin which reflects the mean glycemia of the last 2 months.